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anti-SMAD6 antibody :: Mouse anti-Human SMAD6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245526
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SMAD6, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 4C8] (IgG2b,k) to Human SMAD6

 Product Synonym Names    Anti-SMAD6 Antibody (clone 4C8) IHC-plus; SMAD6; AOVD2; HSMAD6; HsT17432; SMAD 6; MADH7; Mothers against DPP homolog 6; SMAD family member 6; MAD homolog 6; MADH6; Human SMAD6
 Product Gene Name   

anti-SMAD6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614823
 3D Structure    ModBase 3D Structure for O43541
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    4C8
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.2
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 Target Species    Human
 Immunogen Description    SMAD6 (NP_005576, 285 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen Type    Recombinant protein
 Immunogen    SMAD6 antibody was raised against sMAD6 (NP_005576, 285 a.a. ~ 385 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-SMAD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SMAD6 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SMAD6 antibody    ELISA, IHC-P (5 ug/ml), WB
Usage: Antibody has been tested in Western blot using the recombinant protein immunogen as the sample.
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 Immunohistochemistry (IHC) of anti-SMAD6 antibody    Anti-SMAD6 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-SMAD6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SMAD6. It may not necessarily be applicable to this product.
 NCBI GI #    92859871
 NCBI GeneID    4091
 NCBI Accession #    NP_005576.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005585.4 [Other Products]
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 UniProt Primary Accession #    O43541 [Other Products]
 UniProt Secondary Accession #    O43654; Q15799; Q7Z7L4; Q96E31; Q9UKZ3; A9J6M5 [Other Products]
 UniProt Related Accession #    O43541 [Other Products]
 Molecular Weight    35,467 Da
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 NCBI Official Full Name    mothers against decapentaplegic homolog 6
 NCBI Official Synonym Full Names    SMAD family member 6
 NCBI Official Symbol    SMAD6 [Similar Products]
 NCBI Official Synonym Symbols   
AOVD2; MADH6; MADH7; HsT17432
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 6; MAD homolog 6; SMAD, mothers against DPP homolog 6; mothers against decapentaplegic, drosophila, homolog of, 6
 UniProt Protein Name    Mothers against decapentaplegic homolog 6
 UniProt Synonym Protein Names   
SMAD family member 6; SMAD 6; Smad6; hSMAD6
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD6 [Similar Products]
 UniProt Synonym Gene Names    MADH6; MAD homolog 6; Mothers against DPP homolog 6; SMAD 6; Smad6; hSMAD6 [Similar Products]
 UniProt Entry Name    SMAD6_HUMAN
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 NCBI Summary for SMAD6    The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.[provided by RefSeq, Sep 2014]
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 UniProt Comments for SMAD6    SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 15q22.31

Cellular Component: transcription factor complex; protein complex; cytoplasm; cytosol; nucleus

Molecular Function: identical protein binding; protein binding; metal ion binding; ubiquitin protein ligase binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; chromatin binding; transcription factor activity

Biological Process: fat cell differentiation; BMP signaling pathway; negative regulation of cell proliferation; zygotic determination of dorsal/ventral axis; transcription, DNA-dependent; ureteric bud development; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell-substrate adhesion; negative regulation of apoptosis; negative regulation of BMP signaling pathway

Disease: Aortic Valve Disease 2
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 Research Articles on SMAD6    1. Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Mouse Monoclonal [clone 4C8] (IgG2b,k) to Human SMAD6
 Catalog #  Product Name  Catalog #  Product Name
 MBS2063318  APC/CY7-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)  MBS6003257  SMAD6, CT (SMAD6, MADH6, Mothers against decapentaplegic homolog 6, SMAD family member 6)
 MBS241862  Rabbit Polyclonal (IgG) to Human SMAD6  MBS2063335  HRP-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)
 MBS850077  SMAD6 Antibody  MBS2063324  APC/CY7-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)
 MBS2063330  APC/CY7-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)  MBS823736  SMAD6 Blocking Peptide
 MBS1169054  Recombinant Mouse Mothers against decapentaplegic homolog 6 (Smad6)  MBS2063332  APC-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 6 (Smad6)
Products associated with anti-SMAD6 antibodyPathways associated with anti-SMAD6 antibody
 Reference Product  PubMed Publications
 SMAD7 antibody  >173 publications with SMAD6 and SMAD7
 SMAD1 antibody  >126 publications with SMAD6 and SMAD1
 SMAD4 antibody  >90 publications with SMAD6 and SMAD4
 SMAD5 antibody  >56 publications with SMAD6 and SMAD5
 BMPR2 antibody  >28 publications with SMAD6 and BMPR2
 SMURF1 antibody  >15 publications with SMAD6 and SMURF1
 SMURF2 antibody  >7 publications with SMAD6 and SMURF2
 HOXC8 antibody  >2 publications with SMAD6 and HOXC8
 TAB1 antibody  >2 publications with SMAD6 and TAB1
 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with anti-SMAD6 antibodyOrgans/Tissues associated with anti-SMAD6 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >29 publications with SMAD6 and Fibrosis
 Disease Models, Animal Antibodies  >15 publications with SMAD6 and Disease Models, Animal
 Hypertension Antibodies  >13 publications with SMAD6 and Hypertension
 Inflammation Antibodies  >13 publications with SMAD6 and Inflammation
 Kidney Diseases Antibodies  >12 publications with SMAD6 and Kidney Diseases
 Pancreatic Neoplasms Antibodies  >8 publications with SMAD6 and Pancreatic Neoplasms
 Heart Diseases Antibodies  >8 publications with SMAD6 and Heart Diseases
 Necrosis Antibodies  >8 publications with SMAD6 and Necrosis
 Hypertrophy Antibodies  >7 publications with SMAD6 and Hypertrophy
 Neoplasms, Experimental Antibodies  >7 publications with SMAD6 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >219 publications with SMAD6 and Bone
 Embryonic Tissue Antibodies  >32 publications with SMAD6 and Embryonic Tissue
 Kidney Antibodies  >23 publications with SMAD6 and Kidney
 Heart Antibodies  >21 publications with SMAD6 and Heart
 Lung Antibodies  >17 publications with SMAD6 and Lung
 Connective Tissue Antibodies  >16 publications with SMAD6 and Connective Tissue
 Brain Antibodies  >14 publications with SMAD6 and Brain
 Ovary Antibodies  >12 publications with SMAD6 and Ovary
 Parathyroid Antibodies  >8 publications with SMAD6 and Parathyroid
 Eye Antibodies  >7 publications with SMAD6 and Eye
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