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anti-SNCA antibody :: Mouse anti-Human SNCA / Alpha-Synuclein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245464
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SNCA / Alpha-Synuclein, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 5C2] (IgG1,k) to Human SNCA / Alpha-Synuclein

 Product Synonym Names    Anti-SNCA / Alpha-Synuclein Antibody (aa1-140, clone 5C2) IHC-plus; SNCA; Alpha-synuclein; PARK4; PD1; Synuclein alpha-140; NACP; PARK1; Human SNCA; Alpha-Synuclein
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 605543
 3D Structure    ModBase 3D Structure for P37840
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    5C2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    NAC domain of alpha-synuclein (aa 61-95)
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.1% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human kappa-synuclein (1-140) purified from E Coli.
 Immunogen Type    Recombinant protein
 Immunogen    SNCA / Alpha-Synuclein antibody was raised against recombinant human kappa-synuclein (1-140) purified from E Coli.
 Antigen Modification    aa1-140
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SNCA antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SNCA antibody    ELISA, IHC-P (10 ug/ml), WB (1:500 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-SNCA antibody    Anti-SNCA / Alpha-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-SNCA antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SNCA antibody    The recombinant human synuclein family (a-, beta-and ?-) and a-synuclein domains (1-60, 1-95, 61-140 and 96-140) proteins were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-a-Synuclein (61-95 aa) antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-SNCA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    4507109
 NCBI GeneID    6622
 NCBI Accession #    NP_000336.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000345.3 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da
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 NCBI Official Full Name    alpha-synuclein isoform NACP140
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; extracellular region; fibril; terminal button; inclusion body; cell cortex; cytosol; mitochondrial respiratory chain complex I; actin cytoskeleton; synaptic vesicle; platelet alpha granule membrane; growth cone; perinuclear region of cytoplasm; axon; cytoplasm; plasma membrane; ribosome; cell junction; nucleus

Molecular Function: protein domain specific binding; identical protein binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; magnesium ion binding; beta-tubulin binding; phosphoprotein binding; protein N-terminus binding; oxidoreductase activity; Hsp70 protein binding; calcium ion binding; dynein binding; protein binding; copper ion binding; phospholipase binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding

Biological Process: regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; regulation of acyl-CoA biosynthetic process; adult locomotory behavior; positive regulation of apoptosis; negative regulation of norepinephrine uptake; mitochondrial membrane organization and biogenesis; microglial cell activation; response to lipopolysaccharide; positive regulation of endocytosis; negative regulation of monooxygenase activity; negative regulation of transcription from RNA polymerase II promoter; dopamine biosynthetic process; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; positive regulation of neurotransmitter secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; calcium ion homeostasis; response to magnesium ion; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; phospholipid metabolic process; receptor internalization; synapse organization and biogenesis; fibril organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; response to drug; neutral lipid metabolic process; protein destabilization; regulation of glutamate secretion; negative regulation of microtubule polymerization; regulation of macrophage activation; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; negative regulation of dopamine metabolic process; regulation of locomotion; synaptic vesicle endocytosis; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential; negative regulation of transporter activity; negative regulation of apoptosis

Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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 Research Articles on SNCA    1. Data suggest that SNCA mutation (A53E; from Finnish patient with atypical Parkinson's disease) attenuates SNCA aggregation/amyloid formation without altering secondary structure/initial oligomerization; A53E SNCA exhibits reduced membrane binding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >929 publications with SNCA and PARK2
 LRRK2 antibody  >136 publications with SNCA and LRRK2
 PARK7 antibody  >53 publications with SNCA and PARK7
 SNCAIP antibody  >32 publications with SNCA and SNCAIP
 SLC6A3 antibody  >25 publications with SNCA and SLC6A3
 BAD antibody  >3 publications with SNCA and BAD
 FYN antibody  >2 publications with SNCA and FYN
 GRK5 antibody  >1 publications with SNCA and GRK5
 STUB1 antibody  >1 publications with SNCA and STUB1
 UBC antibody  >1 publications with SNCA and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1157 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1133 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1121 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >997 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >923 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >876 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >281 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >166 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >146 publications with SNCA and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >57 publications with SNCA and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1004 publications with SNCA and Nerve
 Brain Antibodies  >796 publications with SNCA and Brain
 Blood Antibodies  >70 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >19 publications with SNCA and Kidney
 Heart Antibodies  >10 publications with SNCA and Heart
 Eye Antibodies  >10 publications with SNCA and Eye
 Bone Antibodies  >8 publications with SNCA and Bone
 Vascular Antibodies  >8 publications with SNCA and Vascular
 Liver Antibodies  >7 publications with SNCA and Liver
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