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anti-SOX10 antibody :: Mouse anti-Human SOX10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS439796
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX10, Monoclonal Antibody

★Popular Item★
 Also Known As   

SOX10 (Melanoma Marker) Mouse Monoclonal Antibody

 Product Synonym Names    DOM; PCWH; SOX10; SRY (sex determining region Y) box 10; SRY box containing gene 10; SRY related HMG box gene 10; Waardenburg syndrome type 2E (WS2E); WS4; Waardenburg syndrome type 4C (WS4C)
 Product Gene Name   

anti-SOX10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602229
 3D Structure    ModBase 3D Structure for P56693
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 Clonality    Monoclonal
 Isotype    IgG2b, kappa
 Clone Number    SOX10/991 + SOX10/1074
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes a protein of ~55kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Nuclear
 Immunogen    Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
 Hu-Chromosome Location    22q13.1
 Positive Control    HepG2 cells. Melanomas, breast carcinomas, gliomas.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of anti-SOX10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SOX10 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for anti-SOX10 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (0.5-1.0ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of anti-SOX10 antibody    Formalin-fixed, paraffin-embedded human Melanoma stained with SOX10 Monoclonal Antibody (SOX10/991 + SOX10/1074).
anti-SOX10 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-SOX10 antibody    Western Blot of SOX10(A) Recombinant protein (B) A375 Cell Lysateusing SOX10 Monoclonal Antibody (SOX10/991 + SOX10/1074).
anti-SOX10 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SOX10. It may not necessarily be applicable to this product.
 NCBI GI #    5902104
 NCBI GeneID    6663
 NCBI Accession #    NP_008872.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006941.3 [Other Products]
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 UniProt Primary Accession #    P56693 [Other Products]
 UniProt Secondary Accession #    Q6FHW7; B4DV62 [Other Products]
 UniProt Related Accession #    P56693 [Other Products]
 Molecular Weight    49-58kDa
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 NCBI Official Full Name    transcription factor SOX-10
 NCBI Official Synonym Full Names    SRY-box 10
 NCBI Official Symbol    SOX10 [Similar Products]
 NCBI Official Synonym Symbols   
DOM; WS4; PCWH; WS2E; WS4C
[Similar Products]
 NCBI Protein Information    transcription factor SOX-10
 UniProt Protein Name    Transcription factor SOX-10
 Protein Family    Transcription factor
 UniProt Gene Name    SOX10 [Similar Products]
 UniProt Entry Name    SOX10_HUMAN
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 NCBI Summary for SOX10    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX10    SOX10: Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia. Defects in SOX10 are the cause of Waardenburg syndrome type 2E (WS2E). WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. Defects in SOX10 are a cause of Waardenburg syndrome type 4C (WS4C); also known as Waardenburg-Shah syndrome. WS4C is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease). Defects in SOX10 are the cause of peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease (PCWH); also called neurologic variant of Waardenburg-Shah syndrome. PCWH is a rare, complex and more severe neurocristopathy that includes features of 4 distinct syndromes: peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding; transcription coactivator activity

Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter

Disease: Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease; Waardenburg Syndrome, Type 2e; Waardenburg Syndrome, Type 4c
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Product References and Citations for anti-SOX10 antibody

   Mohamed A, et al. SOX10 Expression in malignant melanoma, carcinoma, and normal tissues. Appl Immunohistochem Mol Morphol. 2013; 21(6):506-10.-
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 Research Articles on SOX10    1. SOX10 mutations can mimic non-syndromic hearing impairment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOX10 antibodyPathways associated with anti-SOX10 antibody
 Reference Product  PubMed Publications
 MITF antibody  >129 publications with SOX10 and MITF
 PAX3 antibody  >84 publications with SOX10 and PAX3
 OLIG2 antibody  >73 publications with SOX10 and OLIG2
 EDNRB antibody  >64 publications with SOX10 and EDNRB
 EGR2 antibody  >36 publications with SOX10 and EGR2
 FOXD3 antibody  >33 publications with SOX10 and FOXD3
 SNAI2 antibody  >22 publications with SOX10 and SNAI2
 ASCL1 antibody  >8 publications with SOX10 and ASCL1
 NOTCH1 antibody  >7 publications with SOX10 and NOTCH1
 NFATC4 antibody  >3 publications with SOX10 and NFATC4
 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with anti-SOX10 antibodyOrgans/Tissues associated with anti-SOX10 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >153 publications with SOX10 and Nervous System Diseases
 Abnormalities, Multiple Antibodies  >88 publications with SOX10 and Abnormalities, Multiple
 Skin Diseases Antibodies  >62 publications with SOX10 and Skin Diseases
 Peripheral Nervous System Diseases Antibodies  >51 publications with SOX10 and Peripheral Nervous System Diseases
 Skin Neoplasms Antibodies  >42 publications with SOX10 and Skin Neoplasms
 Embryo Loss Antibodies  >29 publications with SOX10 and Embryo Loss
 Nerve Degeneration Antibodies  >13 publications with SOX10 and Nerve Degeneration
 Neoplasms, Experimental Antibodies  >13 publications with SOX10 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >13 publications with SOX10 and Neoplasm Metastasis
 WAARDENBURG SYNDROME, TYPE 4A Antibodies  >10 publications with SOX10 and WAARDENBURG SYNDROME, TYPE 4A
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >239 publications with SOX10 and Nerve
 Embryonic Tissue Antibodies  >158 publications with SOX10 and Embryonic Tissue
 Brain Antibodies  >152 publications with SOX10 and Brain
 Skin Antibodies  >110 publications with SOX10 and Skin
 Ganglia Antibodies  >104 publications with SOX10 and Ganglia
 Ear Antibodies  >44 publications with SOX10 and Ear
 Blood Antibodies  >35 publications with SOX10 and Blood
 Intestine Antibodies  >33 publications with SOX10 and Intestine
 Eye Antibodies  >27 publications with SOX10 and Eye
 Testis Antibodies  >19 publications with SOX10 and Testis
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