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anti-SOX12 antibody :: Mouse anti-Human SOX12 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120310
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX12, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human SOX12

 Product Synonym Names    Homo sapiens SRY (sex determining region Y)-box 12; SOX22
 Product Gene Name   

anti-SOX12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601947
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    86C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-SOX12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SOX12 antibody

   Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-SOX12 antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Western Blot (WB)

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 Quality Control of anti-SOX12 antibody    Western blot analysis of immunized recombinant protein, using anti-SOX12 monoclonal antibody.
anti-SOX12 antibody Quality Control image
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 Quality Control #2 of anti-SOX12 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-SOX12 antibody Quality Control #2 image
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 Western Blot (WB) of anti-SOX12 antibody    Detection of human SOX12 by Western blot.

Samples: Whole cell lysate (25 ug) from HT-1080 cells. [Lot No. 86C2a-1]

Predicted molecular weight: 34 kDa
anti-SOX12 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-SOX12 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SOX12 mAb. [Lot No. 86C2a-1]
anti-SOX12 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for SOX12. It may not necessarily be applicable to this product.
 NCBI GI #    45501271
 NCBI GeneID    6666
 NCBI Accession #    BC067361 [Other Products]
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 UniProt Secondary Accession #    Q5D038; Q9NUD4 [Other Products]
 UniProt Related Accession #    O15370 [Other Products]
 Molecular Weight    34,122 Da
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 NCBI Official Full Name    Homo sapiens SRY (sex determining region Y)-box 12, mRNA
 NCBI Official Synonym Full Names    SRY (sex determining region Y)-box 12
 NCBI Official Symbol    SOX12 [Similar Products]
 NCBI Official Synonym Symbols   
SOX22
[Similar Products]
 NCBI Protein Information    transcription factor SOX-12; SOX-22 protein; SRY-related HMG-box gene 22
 UniProt Protein Name    Transcription factor SOX-12
 UniProt Synonym Protein Names   
Protein SOX-22
 Protein Family    Transcription factor
 UniProt Gene Name    SOX12 [Similar Products]
 UniProt Entry Name    SOX12_HUMAN
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 NCBI Summary for SOX12    Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]
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 UniProt Comments for SOX12    SOX12: Binds to the sequence 5'-AACAAT-3'.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: nucleus

Molecular Function: DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell fate commitment; transcription, DNA-dependent; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly
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 Research Articles on SOX12    1. This genome-wide screen has identified two novel metastatic suppressors: TMED3 and SOX12, the knockdown of which increases metastatic growth after direct seeding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-SOX12 antibodyOrgans/Tissues associated with anti-SOX12 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >1 publications with SOX12 and Neoplasm Metastasis
 Kidney Diseases Antibodies  >1 publications with SOX12 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with SOX12 and Embryonic Tissue
 Testis Antibodies  >2 publications with SOX12 and Testis
 Bone Antibodies  >2 publications with SOX12 and Bone
 Nerve Antibodies  >2 publications with SOX12 and Nerve
 Lung Antibodies  >2 publications with SOX12 and Lung
 Brain Antibodies  >2 publications with SOX12 and Brain
 Muscle Antibodies  >1 publications with SOX12 and Muscle
 Ovary Antibodies  >1 publications with SOX12 and Ovary
 Intestine Antibodies  >1 publications with SOX12 and Intestine
 Eye Antibodies  >1 publications with SOX12 and Eye
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