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anti-SOX4 antibody :: Mouse anti-Human SOX4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120428
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX4, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human SOX4

 Product Synonym Names    Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA.; EVI16
 Product Gene Name   

anti-SOX4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    184430
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    154C4a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-SOX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SOX4 antibody

   This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[NCBI Entrez Gene Summary
 Applications Tested/Suitable for anti-SOX4 antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

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 Quality Control of anti-SOX4 antibody    Western blot analysis of immunized recombinant protein, using anti-SOX4 monoclonal antibody.
anti-SOX4 antibody Quality Control image
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 Quality Control #2 of anti-SOX4 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-SOX4 antibody Quality Control #2 image
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 Immunocytochemistry (ICC) of anti-SOX4 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-SOX4 mAb. [Lot No.154C4a-2]
anti-SOX4 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for SOX4. It may not necessarily be applicable to this product.
 NCBI GI #    30179901
 NCBI GeneID    6659
 NCBI Accession #    NP_003098.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003107 [Other Products]
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 UniProt Related Accession #    Q06945 [Other Products]
 Molecular Weight    47,263 Da
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 NCBI Official Full Name    Homo sapiens SRY (sex determining region Y)-box 4 (SOX4), mRNA
 NCBI Official Synonym Full Names    SRY (sex determining region Y)-box 4
 NCBI Official Symbol    SOX4 [Similar Products]
 NCBI Official Synonym Symbols   
EVI16
[Similar Products]
 NCBI Protein Information    transcription factor SOX-4; SRY-related HMG-box gene 4; ecotropic viral integration site 16
 UniProt Protein Name    Transcription factor SOX-4
 Protein Family    Transcription factor
 UniProt Gene Name    SOX4 [Similar Products]
 UniProt Entry Name    SOX4_HUMAN
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 NCBI Summary for SOX4    This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX4    SOX4: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of protein export from nucleus; positive regulation of translation; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; heart development; regulation of protein stability; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; glial cell proliferation; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; skeletal development; positive regulation of Wnt receptor signaling pathway; T cell differentiation; glial cell development; pro-B cell differentiation; protein stabilization; positive regulation of insulin secretion; DNA damage response, detection of DNA damage; spinal cord motor neuron differentiation; endocrine pancreas development; limb bud formation; spinal cord development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; neural tube formation
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 Research Articles on SOX4    1. SOX4 may modulate expression of EGFR, expression of both SOX4 and EGFR defines a subset of cholangiocarcinoma patients with poor prognosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOX4 antibodyPathways associated with anti-SOX4 antibody
 Reference Product  PubMed Publications
 MEF2C antibody  >3 publications with SOX4 and MEF2C
 SDCBP antibody  >3 publications with SOX4 and SDCBP
 JUP antibody  >2 publications with SOX4 and JUP
 EGFR antibody  >2 publications with SOX4 and EGFR
 DICER1 antibody  >2 publications with SOX4 and DICER1
 TP53 antibody  >2 publications with SOX4 and TP53
 CREBBP antibody  >1 publications with SOX4 and CREBBP
 TBX3 antibody  >1 publications with SOX4 and TBX3
 Products by Pathway  Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with anti-SOX4 antibodyOrgans/Tissues associated with anti-SOX4 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >21 publications with SOX4 and Adenocarcinoma
 Nervous System Diseases Antibodies  >17 publications with SOX4 and Nervous System Diseases
 Breast Neoplasms Antibodies  >15 publications with SOX4 and Breast Neoplasms
 Disease Models, Animal Antibodies  >14 publications with SOX4 and Disease Models, Animal
 Lung Neoplasms Antibodies  >13 publications with SOX4 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >12 publications with SOX4 and Cell Transformation, Neoplastic
 Prostatic Neoplasms Antibodies  >10 publications with SOX4 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with SOX4 and Neoplasms, Experimental
 Liver Diseases Antibodies  >8 publications with SOX4 and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with SOX4 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with SOX4 and Blood
 Brain Antibodies  >30 publications with SOX4 and Brain
 Embryonic Tissue Antibodies  >29 publications with SOX4 and Embryonic Tissue
 Bone Antibodies  >28 publications with SOX4 and Bone
 Lung Antibodies  >26 publications with SOX4 and Lung
 Heart Antibodies  >19 publications with SOX4 and Heart
 Nerve Antibodies  >14 publications with SOX4 and Nerve
 Liver Antibodies  >14 publications with SOX4 and Liver
 Pancreas Antibodies  >13 publications with SOX4 and Pancreas
 Bone Marrow Antibodies  >12 publications with SOX4 and Bone Marrow
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