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anti-SOX9 antibody :: Mouse SOX9/SRY-box 9 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380489
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $340 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $340 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SOX9/SRY-box 9, Monoclonal Antibody

★Popular Item★
 Also Known As   

SOX9/SRY-box 9

 Product Synonym Names    Campomelic Dysplasia Autosomal Sex Reversal (CMD1); SRA1; SRXX2; SRY (sex determining region Y) box 9; SRY related HMG box gene 9; Transcription factor SOX9
 Product Gene Name   

anti-SOX9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P48436
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    PCRP-SOX9-1A2
 Host    Mouse
 Species Reactivity    Human. Others not tested.
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 Specificity    The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19, 000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant full-length human SOX9 protein
 Cellular Localization    Nuclear
 Hu-chromosome Location    17q24.3
 Positive Control    HepG2 Cells. Pancreas
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 Other Notes    Small volumes of anti-SOX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SOX9 antibody   

Immunohistochemistry (IHC) Formalin

 Application Notes for anti-SOX9 antibody    IHC-F: 2-4ug/ml for 30 min at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 Immunohistochemistry (IHC) of anti-SOX9 antibody    Formalin-fixed, paraffin-embedded human Pancreas stained with SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2).
anti-SOX9 antibody Immunohistochemistry (IHC) (IHC) image
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 SDS-Page of anti-SOX9 antibody    SDS-PAGE Analysis Purified SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2).Confirmation of Integrity and Purity of Antibody.
anti-SOX9 antibody SDS-Page image
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 Testing Data of anti-SOX9 antibody    Analysis of Protein Array containing more than 19, 000 full-length human proteins using SOX9 Mouse Monoclonal Antibody (PCRP-SOX9-1A2) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
anti-SOX9 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SOX9. It may not necessarily be applicable to this product.
 NCBI GI #    4557853
 NCBI GeneID    6662
 NCBI Accession #    NP_000337.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000346.3 [Other Products]
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 UniProt Primary Accession #    P48436 [Other Products]
 UniProt Secondary Accession #    Q53Y80 [Other Products]
 UniProt Related Accession #    P48436 [Other Products]
 Molecular Weight    65kDa
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 NCBI Official Full Name    transcription factor SOX-9
 NCBI Official Synonym Full Names    SRY-box 9
 NCBI Official Symbol    SOX9 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    transcription factor SOX-9
 UniProt Protein Name    Transcription factor SOX-9
 Protein Family    Transcription factor
 UniProt Gene Name    SOX9 [Similar Products]
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 NCBI Summary for SOX9    The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SOX9    Transcriptional regulator (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (). Plays a role in chondrocyte differentiation (). Important for normal skeletal development (PubMed:24038782).
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Product References and Citations for anti-SOX9 antibody

   Zhu, H., et al. 2013. Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients prognosis. Diagn.Pathol. 8:183.
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 Research Articles on SOX9    1. miR-185 inversely regulates SOX9 expression in non-small cell lung cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SOX9 antibodyPathways associated with anti-SOX9 antibody
 Reference Product  PubMed Publications
 NR5A1 antibody  >24 publications with SOX9 and NR5A1
 CREBBP antibody  >5 publications with SOX9 and CREBBP
 MED12 antibody  >4 publications with SOX9 and MED12
 EP300 antibody  >4 publications with SOX9 and EP300
 CREB1 antibody  >4 publications with SOX9 and CREB1
 MAF antibody  >3 publications with SOX9 and MAF
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with anti-SOX9 antibodyOrgans/Tissues associated with anti-SOX9 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >169 publications with SOX9 and Neoplasms
 Campomelic Dysplasia Antibodies  >116 publications with SOX9 and Campomelic Dysplasia
 Hypertrophy Antibodies  >76 publications with SOX9 and Hypertrophy
 Carcinoma Antibodies  >65 publications with SOX9 and Carcinoma
 Disease Models, Animal Antibodies  >59 publications with SOX9 and Disease Models, Animal
 Nervous System Diseases Antibodies  >50 publications with SOX9 and Nervous System Diseases
 Adenocarcinoma Antibodies  >36 publications with SOX9 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >34 publications with SOX9 and Cardiovascular Diseases
 Craniofacial Abnormalities Antibodies  >34 publications with SOX9 and Craniofacial Abnormalities
 Inflammation Antibodies  >33 publications with SOX9 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >696 publications with SOX9 and Bone
 Testis Antibodies  >389 publications with SOX9 and Testis
 Connective Tissue Antibodies  >356 publications with SOX9 and Connective Tissue
 Embryonic Tissue Antibodies  >300 publications with SOX9 and Embryonic Tissue
 Muscle Antibodies  >95 publications with SOX9 and Muscle
 Brain Antibodies  >84 publications with SOX9 and Brain
 Nerve Antibodies  >67 publications with SOX9 and Nerve
 Skin Antibodies  >64 publications with SOX9 and Skin
 Pancreas Antibodies  >55 publications with SOX9 and Pancreas
 Liver Antibodies  >54 publications with SOX9 and Liver
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