NP_003131.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
Observed: 23.9 kDa Predicted: 24 kDa
NCBI Official Full Name
sex-determining region Y protein
NCBI Official Synonym Full Names
sex determining region Y
NCBI Protein Information
sex-determining region Y protein
UniProt Protein Name
Sex-determining region Y protein
UniProt Synonym Protein Names
Testis-determining factor
UniProt Synonym Gene Names
NCBI Summary for SRY
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for SRY
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (). Involved in different aspects of gene regulation including promoter activation or repression (). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.
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Products associated with anti-SRY antibody
Pathways associated with anti-SRY antibody
Diseases associated with anti-SRY antibody
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