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anti-STAT3 antibody :: Mouse STAT3/Signal Transducer and Activator of Transcription 3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS4380496
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $340 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAT3/Signal Transducer and Activator of Transcription 3, Monoclonal Antibody

★Popular Item★
 Also Known As   

STAT3/Signal Transducer and Activator of Transcription 3

 Product Synonym Names    APRF; HIES; ADMIO; ADMIO1
 Product Gene Name   

anti-STAT3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P40763
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    PCRP-STAT3-2F12
 Host    Mouse
 Species Reactivity    Human. Others not tested.
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 Specificity    The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19, 000, full-length human proteins. STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant full-length human STAT3 protein
 Cellular Localization    Cytoplasmic and Nuclear
 Hu-chromosome Location    17q21.2
 Positive Control    A431 and Raji cells. Kidney, Brain or Heart
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 Other Notes    Small volumes of anti-STAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-STAT3 antibody   

ELISA (EIA)

 Application Notes for anti-STAT3 antibody    ELISA: Use Ab at 2-4ug/ml for coating. Order Ab without BSA.
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 SDS-Page of anti-STAT3 antibody    SDS-PAGE Analysis Purified STAT3 Mouse Monoclonal Antibody (PCRP-STAT3-2F12).Confirmation of Integrity and Purity of Antibody.
anti-STAT3 antibody SDS-Page image
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 Testing Data of anti-STAT3 antibody    Analysis of Protein Array containing >19, 000 full-length human proteins using STAT3 Mouse Monoclonal Antibody (PCRP-STAT3-2F12). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
anti-STAT3 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for STAT3. It may not necessarily be applicable to this product.
 NCBI GI #    21618338
 NCBI GeneID    6774
 NCBI Accession #    NP_003141.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003150.3 [Other Products]
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 UniProt Primary Accession #    P40763 [Other Products]
 UniProt Secondary Accession #    O14916; Q9BW54; A8K7B8; K7ENL3 [Other Products]
 UniProt Related Accession #    P40763 [Other Products]
 Molecular Weight    88kDa
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 NCBI Official Full Name    signal transducer and activator of transcription 3 isoform 2
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 3
 NCBI Official Symbol    STAT3 [Similar Products]
 NCBI Official Synonym Symbols   
APRF; HIES; ADMIO; ADMIO1
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 3
 UniProt Protein Name    Signal transducer and activator of transcription 3
 UniProt Synonym Protein Names   
Acute-phase response factor
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT3 [Similar Products]
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 NCBI Summary for STAT3    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
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 UniProt Comments for STAT3    Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4+ T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion ().
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Product References and Citations for anti-STAT3 antibody

   Zhong, Z., et al. 1994. Science 264: 95-98.
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 Research Articles on STAT3    1. High STAT3 expression is associated with hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAT3 antibodyPathways associated with anti-STAT3 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >1582 publications with STAT3 and STAT1
 JAK2 antibody  >1192 publications with STAT3 and JAK2
 JUN antibody  >1154 publications with STAT3 and JUN
 SRC antibody  >679 publications with STAT3 and SRC
 JAK1 antibody  >525 publications with STAT3 and JAK1
 CCND1 antibody  >394 publications with STAT3 and CCND1
 EGFR antibody  >348 publications with STAT3 and EGFR
 MAPK3 antibody  >281 publications with STAT3 and MAPK3
 IL6ST antibody  >268 publications with STAT3 and IL6ST
 MAPK1 antibody  >259 publications with STAT3 and MAPK1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-STAT3 antibodyOrgans/Tissues associated with anti-STAT3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3305 publications with STAT3 and Neoplasms
 Inflammation Antibodies  >1328 publications with STAT3 and Inflammation
 Carcinoma Antibodies  >1198 publications with STAT3 and Carcinoma
 Necrosis Antibodies  >654 publications with STAT3 and Necrosis
 Adenocarcinoma Antibodies  >529 publications with STAT3 and Adenocarcinoma
 Liver Diseases Antibodies  >501 publications with STAT3 and Liver Diseases
 Breast Neoplasms Antibodies  >378 publications with STAT3 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >377 publications with STAT3 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >303 publications with STAT3 and Liver Neoplasms
 Lung Neoplasms Antibodies  >259 publications with STAT3 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2204 publications with STAT3 and Blood
 Liver Antibodies  >1065 publications with STAT3 and Liver
 Brain Antibodies  >872 publications with STAT3 and Brain
 Vascular Antibodies  >784 publications with STAT3 and Vascular
 Muscle Antibodies  >655 publications with STAT3 and Muscle
 Lung Antibodies  >613 publications with STAT3 and Lung
 Bone Antibodies  >604 publications with STAT3 and Bone
 Heart Antibodies  >464 publications with STAT3 and Heart
 Bone Marrow Antibodies  >402 publications with STAT3 and Bone Marrow
 Skin Antibodies  >398 publications with STAT3 and Skin
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