NP_003141.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,126 Da
NCBI Official Full Name
signal transducer and activator of transcription 3 isoform 2
NCBI Official Synonym Full Names
signal transducer and activator of transcription 3
NCBI Protein Information
signal transducer and activator of transcription 3
UniProt Protein Name
Signal transducer and activator of transcription 3
UniProt Synonym Protein Names
Acute-phase response factor
NCBI Summary for STAT3
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
UniProt Comments for STAT3
STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; plasma membrane
Molecular Function: chromatin DNA binding; DNA binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor activity; transcription factor binding
Biological Process: astrocyte differentiation; cell motility; cellular response to hormone stimulus; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to estradiol stimulus; sexual reproduction; signal transduction; somatic stem cell maintenance; thermoregulation
Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant
Research Articles on STAT3
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Products associated with anti-STAT3 antibody
Pathways associated with anti-STAT3 antibody
Diseases associated with anti-STAT3 antibody
Organs/Tissues associated with anti-STAT3 antibody
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