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anti-STAT5B antibody :: Mouse anti-Human STAT5B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533206
Western Blot
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STAT5B, Monoclonal Antibody

 Also Known As   

STAT5B antibody

 Product Synonym Names    Monoclonal STAT5B; Anti-STAT5B; STAT5B; STATB-5; Signal transducer and activator of transcription 5B; STAT5; STATB 5
 Product Gene Name   

anti-STAT5B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    245590
 3D Structure    ModBase 3D Structure for P51692
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    5B3
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    STAT5B is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
 Immunogen    STAT5B antibody was raised in Mouse using a purified recombinant fragment of human STAT5B expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-STAT5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-STAT5B antibody

   Mouse monoclonal STAT5B antibody
 Product Categories/Family for anti-STAT5B antibody    Cell Biology
 Applications Tested/Suitable for anti-STAT5B antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-STAT5B antibody    ELISA: 1:10,000
WB: 1:200-1:1000
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 Western Blot of anti-STAT5B antibody    Western Blot analysis using STAT5B antibody
Western Blot showing STAT5B antibody used against Hela (1), K562 (2), NIH/3T3 (3), C6 (4), HEK293 (5), Jurkat (6) and HL-60 (7) cell lysate.
anti-STAT5B antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for STAT5B. It may not necessarily be applicable to this product.
 NCBI GI #    21618344
 NCBI GeneID    6777
 NCBI Accession #    NP_036580.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012448.3 [Other Products]
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 UniProt Primary Accession #    P51692 [Other Products]
 UniProt Secondary Accession #    Q8WWS8 [Other Products]
 UniProt Related Accession #    P51692 [Other Products]
 Molecular Weight    89,866 Da
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 NCBI Official Full Name    signal transducer and activator of transcription 5B
 NCBI Official Synonym Full Names    signal transducer and activator of transcription 5B
 NCBI Official Symbol    STAT5B [Similar Products]
 NCBI Official Synonym Symbols   
STAT5
[Similar Products]
 NCBI Protein Information    signal transducer and activator of transcription 5B
 UniProt Protein Name    Signal transducer and activator of transcription 5B
 Protein Family    Signal transducer and activator of transcription
 UniProt Gene Name    STAT5B [Similar Products]
 UniProt Entry Name    STA5B_HUMAN
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 NCBI Summary for STAT5B    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STAT5B    STAT5B: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription.

Protein type: DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; protein binding; signal transducer activity; double-stranded DNA binding; chromatin binding; transcription factor activity; protein phosphatase binding; glucocorticoid receptor binding

Biological Process: lactation; transcription from RNA polymerase II promoter; succinate metabolic process; oxaloacetate metabolic process; positive regulation of interleukin-2 biosynthetic process; positive regulation of smooth muscle cell proliferation; T cell differentiation in the thymus; response to lipopolysaccharide; positive regulation of multicellular organism growth; female pregnancy; progesterone metabolic process; positive regulation of activated T cell proliferation; fatty acid metabolic process; positive regulation of mitotic cell cycle; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; natural killer cell differentiation; allantoin metabolic process; luteinization; regulation of steroid metabolic process; development of secondary male sexual characteristics; creatinine metabolic process; acute-phase response; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer's patch development; isoleucine metabolic process; negative regulation of erythrocyte differentiation; positive regulation of natural killer cell proliferation; regulation of multicellular organism growth; citrate metabolic process; valine metabolic process; development of secondary female sexual characteristics; positive regulation of cell motility; positive regulation of natural killer cell mediated cytotoxicity; liver development; JAK-STAT cascade; creatine metabolic process; cellular response to hormone stimulus; regulation of transcription from RNA polymerase II promoter; response to ethanol; regulation of epithelial cell differentiation; response to hypoxia; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response; negative regulation of apoptosis

Disease: Growth Hormone Insensitivity With Immunodeficiency
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 Research Articles on STAT5B    1. study showed that a common mutation of STAT5B results in constitutive STAT5B phosphorylation, growth factor-independent proliferation in cell-based assays, activation of downstream targets in leukemia cells of children with T-cell acute lymphoblastic leukemia and a higher risk of relapse
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STAT5B antibodyPathways associated with anti-STAT5B antibody
 Reference Product  PubMed Publications
 JAK2 antibody  >162 publications with STAT5B and JAK2
 GHR antibody  >63 publications with STAT5B and GHR
 JAK1 antibody  >42 publications with STAT5B and JAK1
 JAK3 antibody  >37 publications with STAT5B and JAK3
 EGFR antibody  >27 publications with STAT5B and EGFR
 SOCS3 antibody  >21 publications with STAT5B and SOCS3
 TYK2 antibody  >18 publications with STAT5B and TYK2
 BCL2L1 antibody  >15 publications with STAT5B and BCL2L1
 EPOR antibody  >9 publications with STAT5B and EPOR
 PRLR antibody  >8 publications with STAT5B and PRLR
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
Diseases associated with anti-STAT5B antibodyOrgans/Tissues associated with anti-STAT5B antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >44 publications with STAT5B and Breast Neoplasms
 Inflammation Antibodies  >33 publications with STAT5B and Inflammation
 Kidney Diseases Antibodies  >24 publications with STAT5B and Kidney Diseases
 Liver Diseases Antibodies  >24 publications with STAT5B and Liver Diseases
 Necrosis Antibodies  >19 publications with STAT5B and Necrosis
 Cardiovascular Diseases Antibodies  >18 publications with STAT5B and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >17 publications with STAT5B and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >13 publications with STAT5B and Neoplasms, Experimental
 Heart Diseases Antibodies  >12 publications with STAT5B and Heart Diseases
 Lung Diseases Antibodies  >12 publications with STAT5B and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >218 publications with STAT5B and Blood
 Liver Antibodies  >139 publications with STAT5B and Liver
 Bone Antibodies  >52 publications with STAT5B and Bone
 Mammary Gland Antibodies  >40 publications with STAT5B and Mammary Gland
 Muscle Antibodies  >35 publications with STAT5B and Muscle
 Brain Antibodies  >31 publications with STAT5B and Brain
 Kidney Antibodies  >30 publications with STAT5B and Kidney
 Lung Antibodies  >29 publications with STAT5B and Lung
 Skin Antibodies  >17 publications with STAT5B and Skin
 Vascular Antibodies  >17 publications with STAT5B and Vascular
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