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anti-STIM1 antibody :: Mouse STIM1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7604554
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STIM1, Monoclonal Antibody

★Popular Item★
 Also Known As   

STIM1 Mouse Monoclonal

 Product Synonym Names    Sim
 Product Gene Name   

anti-STIM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7604554 Technical Datasheet    Technical Datasheet PDF
 OMIM    160565
 3D Structure    ModBase 3D Structure for P84903
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Rat, Human, Mouse
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 Specificity    Human, Mouse ,Rat; other species are not tested. Please decide the specificity by homology
 Purity/Purification    Purity: >=95% as determined by SDS-PAGE
Purification: Protein A+G purification
 Form/Format    Liquid
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 Immunogen    Stromal interaction molecule 1
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
 Calculated MW    77 kD
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 Preparation and Storage    Store at -20C for 24 months (Avoid repeated freeze/thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-STIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-STIM1 antibody

   Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (By similarity). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375). Involved in enamel formation (By similarity). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch (By similarity).
 Applications Tested/Suitable for anti-STIM1 antibody   

ELISA (EIA), Western Blot (WB), Immunohisctochemistry (IHC)

 Application Notes for anti-STIM1 antibody    WB : 1:200-1:2000
IHC : 1:50-1:500
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 Immunohistochemistry of anti-STIM1 antibody    Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using MBS7604554 (STIM1 Antibody) at dilution of 1:200. heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
anti-STIM1 antibody Immunohistochemistry (IHC) image
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 SDS-PAGE of anti-STIM1 antibody    Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7604554 (STIM1 Antibody) at dilution of 1:500
anti-STIM1 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for STIM1. It may not necessarily be applicable to this product.
 NCBI GI #    429142778
 NCBI GeneID    6786
 NCBI Accession #    AFZ76986.1 [Other Products]
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 UniProt Primary Accession #    P84903 [Other Products]
 UniProt Secondary Accession #    Q8N382; E9PQJ4 [Other Products]
 UniProt Related Accession #    Q13586 [Other Products]
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 NCBI Official Full Name    STIM1
 NCBI Official Synonym Full Names    stromal interaction molecule 1
 NCBI Official Symbol    STIM1 [Similar Products]
 NCBI Official Synonym Symbols   
GOK; TAM; TAM1; IMD10; STRMK; D11S4896E
[Similar Products]
 NCBI Protein Information    stromal interaction molecule 1
 UniProt Protein Name    Stromal interaction molecule 1
 Protein Family    Stromal interaction molecule
 UniProt Gene Name    STIM1 [Similar Products]
 UniProt Synonym Gene Names    [Similar Products]
 UniProt Entry Name    STIM1_HUMAN
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 NCBI Summary for STIM1    This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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 UniProt Comments for STIM1    STIM1: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1. Forms homooligomers and heterooligomers with STIM2. Interacts with ORAI1. Interacts with MAPRE1; probably required for targeting to the growing microtubule plus ends. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and ORAI1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Interacts with TMEM66/SARAF, promoting a slow inactivation of STIM1-dependent SOCE activity, possibly by facilitating the deoligomerization of STIM1. Ubiquitously expressed in various human primary cells and tumor cell lines.

Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to plasma membrane; microtubule; sarcoplasmic reticulum membrane

Molecular Function: calcium channel regulator activity; calcium ion binding; identical protein binding; microtubule plus-end binding; protease binding; protein binding

Biological Process: activation of store-operated calcium channel activity; calcium ion transport; detection of calcium ion; regulation of calcium ion transport

Disease: Immunodeficiency 10; Myopathy, Tubular Aggregate, 1
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 Research Articles on STIM1    1. The abundance of mutated STIM1 and the MMP-2 expression were higher in native human umbilical vein endothelial cells of patients with gestational hypertension than controls and were significantly correlated with blood pressure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STIM1 antibodyPathways associated with anti-STIM1 antibody
 Reference Product  PubMed Publications
 ORAI1 antibody  >768 publications with STIM1 and ORAI1
 TRPC1 antibody  >149 publications with STIM1 and TRPC1
 ORAI3 antibody  >91 publications with STIM1 and ORAI3
 ORAI2 antibody  >60 publications with STIM1 and ORAI2
 TRPC4 antibody  >26 publications with STIM1 and TRPC4
 TRPC5 antibody  >16 publications with STIM1 and TRPC5
 ITPR1 antibody  >4 publications with STIM1 and ITPR1
 ITPR3 antibody  >3 publications with STIM1 and ITPR3
 ITPR2 antibody  >1 publications with STIM1 and ITPR2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Elevation Of Cytosolic Ca2+ Levels Pathway antibodies  Elevation Of Cytosolic Ca2+ Levels Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
Diseases associated with anti-STIM1 antibodyOrgans/Tissues associated with anti-STIM1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >56 publications with STIM1 and Cardiovascular Diseases
 Inflammation Antibodies  >46 publications with STIM1 and Inflammation
 Disease Models, Animal Antibodies  >39 publications with STIM1 and Disease Models, Animal
 Necrosis Antibodies  >20 publications with STIM1 and Necrosis
 Hypertrophy Antibodies  >15 publications with STIM1 and Hypertrophy
 Hypertension Antibodies  >15 publications with STIM1 and Hypertension
 Kidney Diseases Antibodies  >13 publications with STIM1 and Kidney Diseases
 Fibrosis Antibodies  >10 publications with STIM1 and Fibrosis
 Hyperplasia Antibodies  >9 publications with STIM1 and Hyperplasia
 Cardiomegaly Antibodies  >8 publications with STIM1 and Cardiomegaly
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >183 publications with STIM1 and Blood
 Muscle Antibodies  >174 publications with STIM1 and Muscle
 Vascular Antibodies  >108 publications with STIM1 and Vascular
 Brain Antibodies  >74 publications with STIM1 and Brain
 Heart Antibodies  >52 publications with STIM1 and Heart
 Lung Antibodies  >50 publications with STIM1 and Lung
 Kidney Antibodies  >45 publications with STIM1 and Kidney
 Bone Antibodies  >28 publications with STIM1 and Bone
 Liver Antibodies  >27 publications with STIM1 and Liver
 Nerve Antibodies  >24 publications with STIM1 and Nerve
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