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anti-STK38 antibody :: Mouse STK38 / NDR Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245972
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

STK38 / NDR, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 6F1] (IgG2a,k) to Human STK38 / NDR

 Product Synonym Names    Anti-STK38 / NDR Antibody (clone 6F1) IHC-plus; STK38; NDR1 protein kinase; Nuclear Dbf2-related kinase 1; NDR1; NDR; Ndr protein kinase; Nuclear Dbf2-related 1; Serine/threonine kinase 38; Human STK38; NDR
 Product Gene Name   

anti-STK38 antibody

[Similar Products]
 Product Synonym Gene Name    NDR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606964
 3D Structure    ModBase 3D Structure for Q15208
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 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    6F1
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human STK38
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.4. Sourced in Ascites.
 Concentration    0.31 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    STK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen    STK38 / NDR antibody was raised against sTK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-STK38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-STK38 antibody

   NDR is a nuclear NDR/LATS serine/threonine kinase. Ndr kinases are endogenous inhibitors of neurite initiation and cell spreading.
 Product Categories/Family for anti-STK38 antibody    Family: Protein Kinase
Subfamily: NDR/LATS
 Applications Tested/Suitable for anti-STK38 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-STK38 antibody    ELISA, IHC-P (1 - 10 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.
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 Immunohistochemistry (IHC) of anti-STK38 antibody    Anti-STK38 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 1 ug/ml.
anti-STK38 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-STK38 antibody    Antibody, Western blot of STK38 expression in PC-12.
anti-STK38 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-STK38 antibody    Antibody, Western blot of STK38 expression in NIH/3T3.
anti-STK38 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-STK38 antibody    Antibody, Western blot of STK38 expression in HeLa NE.
anti-STK38 antibody Western Blot (WB) (WB) image
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 ELISA (EIA) of anti-STK38 antibody    Detection limit for recombinant GST tagged STK38 is approximately 0.1 ng/ml as a capture antibody.
anti-STK38 antibody ELISA (EIA) image
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NCBI/Uniprot data below describe general gene information for STK38. It may not necessarily be applicable to this product.
 NCBI GI #    6005814
 NCBI GeneID    11329
 NCBI Accession #    NP_009202.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007271.2 [Other Products]
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 UniProt Primary Accession #    Q15208 [Other Products]
 UniProt Secondary Accession #    Q503A1 [Other Products]
 UniProt Related Accession #    Q15208 [Other Products]
 Molecular Weight    54,190 Da
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 NCBI Official Full Name    serine/threonine-protein kinase 38
 NCBI Official Synonym Full Names    serine/threonine kinase 38
 NCBI Official Symbol    STK38 [Similar Products]
 NCBI Official Synonym Symbols   
NDR; NDR1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase 38; STK38; NDR1 protein kinase; nuclear Dbf2-related 1; nuclear Dbf2-related kinase 1; Ndr Ser/Thr kinase-like protein; serine threonine protein kinase
 UniProt Protein Name    Serine/threonine-protein kinase 38
 UniProt Synonym Protein Names   
NDR1 protein kinase; Nuclear Dbf2-related kinase 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    STK38 [Similar Products]
 UniProt Entry Name    STK38_HUMAN
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 NCBI Summary for STK38    This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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 UniProt Comments for STK38    NDR1: is an AGC kinase of the NDR family. An apparent upstream regulator of Myc activity in human B-cell lymphoma. Mediates apoptosis downstream of the tumor suppressor proteins RASSF1A and MST1. Reduced expression of NDR1 results in defective apoptotic responses and a predisposition to develop T cell lymphoma in mice. Activated by binding of S100B which releases autoinhibitory N-lobe interactions. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; AGC group; NDR family

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; mitogen-activated protein kinase kinase kinase binding; ATP binding

Biological Process: negative regulation of MAP kinase activity; protein modification process; protein amino acid phosphorylation
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 Research Articles on STK38    1. STK38 regulates MYC protein stability and turnover in a kinase activity-dependent manner. STK38 kinase inactivation abrogates apoptosis following B-cell receptor activation, whereas its silencing significantly decreases MYC levels and increases apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STK38 antibodyDiseases associated with anti-STK38 antibody
 Reference Product  PubMed Publications
 HCCA2 antibody  >3 publications with STK38 and HCCA2
 S100B antibody  >1 publications with STK38 and S100B
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with STK38 and Adenocarcinoma
 Breast Neoplasms Antibodies  >2 publications with STK38 and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with STK38 and Liver Diseases
 Neoplasm Metastasis Antibodies  >2 publications with STK38 and Neoplasm Metastasis
 Necrosis Antibodies  >2 publications with STK38 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with STK38 and Carcinoma, Hepatocellular
 Precancerous Conditions Antibodies  >1 publications with STK38 and Precancerous Conditions
Organs/Tissues associated with anti-STK38 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with STK38 and Blood
 Liver Antibodies  >1 publications with STK38 and Liver
 Thymus Antibodies  >1 publications with STK38 and Thymus
 Kidney Antibodies  >1 publications with STK38 and Kidney
 Uncharacterized Tissue Antibodies  >1 publications with STK38 and Uncharacterized Tissue
 Stomach Antibodies  >1 publications with STK38 and Stomach
 Heart Antibodies  >1 publications with STK38 and Heart
 Lung Antibodies  >1 publications with STK38 and Lung
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