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anti-SFRP1 antibody :: Mouse anti-Human Secreted Frizzled Related Protein 1 (SFRP1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090613
Western Blot (WB)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $185 +1 FREE 8GB USB
0.2 mg  /  $230 +1 FREE 8GB USB
1 mg  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Secreted Frizzled Related Protein 1 (SFRP1), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Secreted Frizzled Related Protein 1 (SFRP1)

 Product Synonym Names    FRP1; FRP; FRP-1; FrzA; SARP2; Secreted apoptosis-related protein 2
 Product Gene Name   

anti-SFRP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF001900 mRNA
 3D Structure    ModBase 3D Structure for Q8N474
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 Clonality    Monoclonal
 Isotype    IgG2a Kappa
 Clone Number    C4
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against SFRP1. It has been selected for its ability to recognize SFRP1 in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Secreted Frizzled Related Protein 1 (SFRP1)
 Buffer Formulation    0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-SFRP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SFRP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-SFRP1 antibody    Western Blot: 0.5-5ug/mL
Immunohistochemistry: 5-30ug/mL
Immunocytochemistry: 5-30ug/mL
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 Western Blot (WB) of anti-SFRP1 antibody    (Figure. Western Blot; Sample: Recombinant SFRP1, Human.)
anti-SFRP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SFRP1. It may not necessarily be applicable to this product.
 NCBI GI #    56117838
 NCBI GeneID    6422
 NCBI Accession #    NP_003003.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003012.4 [Other Products]
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 UniProt Primary Accession #    Q8N474 [Other Products]
 UniProt Secondary Accession #    O00546; O14779 [Other Products]
 UniProt Related Accession #    Q8N474 [Other Products]
 Molecular Weight    35,386 Da
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 NCBI Official Full Name    secreted frizzled-related protein 1
 NCBI Official Synonym Full Names    secreted frizzled related protein 1
 NCBI Official Symbol    SFRP1 [Similar Products]
 NCBI Official Synonym Symbols   
FRP; FRP1; FrzA; FRP-1; SARP2
[Similar Products]
 NCBI Protein Information    secreted frizzled-related protein 1
 UniProt Protein Name    Secreted frizzled-related protein 1
 UniProt Synonym Protein Names   
Secreted apoptosis-related protein 2; SARP-2
 Protein Family    Secreted frizzled-related protein
 UniProt Gene Name    SFRP1 [Similar Products]
 UniProt Synonym Gene Names    FRP; FRP1; SARP2; FRP-1; sFRP-1; SARP-2 [Similar Products]
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 NCBI Summary for SFRP1    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
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 UniProt Comments for SFRP1    SFRP1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: cell surface; cytosol; extracellular matrix; extracellular region; extracellular space; integral component of membrane; intracellular; plasma membrane; proteinaceous extracellular matrix

Molecular Function: cysteine-type endopeptidase activity; drug binding; frizzled binding; G-protein coupled receptor activity; heparin binding; identical protein binding; protein binding; Wnt-activated receptor activity; Wnt-protein binding

Biological Process: cellular response to starvation; digestive tract morphogenesis; dorsal/ventral axis specification; female gonad development; G-protein coupled receptor signaling pathway; hemopoietic progenitor cell differentiation; male gonad development; menstrual cycle phase; negative regulation of apoptosis; negative regulation of B cell differentiation; negative regulation of BMP signaling pathway; negative regulation of bone remodeling; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of insulin secretion; negative regulation of JNK activity; negative regulation of ossification; negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; negative regulation of osteoclast differentiation; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt signaling pathway; neural crest cell fate commitment; osteoblast differentiation; positive regulation of apoptosis; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of epithelial cell proliferation; positive regulation of fat cell differentiation; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of smoothened signaling pathway; positive regulation of stress fiber formation; positive regulation of transcription, DNA-templated; positive regulation of Wnt receptor signaling pathway; proteolysis; regulation of angiogenesis; response to drug; response to organic cyclic compound; somatic stem cell maintenance; ureteric bud development; Wnt receptor signaling pathway through beta-catenin
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 Research Articles on SFRP1    1. The expression of Dicer negatively correlated with that of SFRP1 and it appeared to promote CCA cell proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SFRP1 antibodyPathways associated with anti-SFRP1 antibody
 Reference Product  PubMed Publications
 WNT3A antibody  >26 publications with SFRP1 and WNT3A
 MYC antibody  >25 publications with SFRP1 and MYC
 WNT1 antibody  >16 publications with SFRP1 and WNT1
 WNT10B antibody  >15 publications with SFRP1 and WNT10B
 WNT4 antibody  >12 publications with SFRP1 and WNT4
 WNT7B antibody  >9 publications with SFRP1 and WNT7B
 WNT2 antibody  >9 publications with SFRP1 and WNT2
 FZD6 antibody  >5 publications with SFRP1 and FZD6
 MAX antibody  >4 publications with SFRP1 and MAX
 WNT8B antibody  >4 publications with SFRP1 and WNT8B
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with anti-SFRP1 antibodyOrgans/Tissues associated with anti-SFRP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >233 publications with SFRP1 and Neoplasms
 Carcinoma Antibodies  >102 publications with SFRP1 and Carcinoma
 Adenocarcinoma Antibodies  >56 publications with SFRP1 and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >43 publications with SFRP1 and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >40 publications with SFRP1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >19 publications with SFRP1 and Liver Neoplasms
 Liver Diseases Antibodies  >18 publications with SFRP1 and Liver Diseases
 Lung Neoplasms Antibodies  >18 publications with SFRP1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >16 publications with SFRP1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >16 publications with SFRP1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >65 publications with SFRP1 and Bone
 Eye Antibodies  >60 publications with SFRP1 and Eye
 Brain Antibodies  >31 publications with SFRP1 and Brain
 Embryonic Tissue Antibodies  >27 publications with SFRP1 and Embryonic Tissue
 Lung Antibodies  >26 publications with SFRP1 and Lung
 Muscle Antibodies  >24 publications with SFRP1 and Muscle
 Liver Antibodies  >24 publications with SFRP1 and Liver
 Kidney Antibodies  >23 publications with SFRP1 and Kidney
 Connective Tissue Antibodies  >21 publications with SFRP1 and Connective Tissue
 Intestine Antibodies  >20 publications with SFRP1 and Intestine
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