View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-SerpinC1 antibody :: Rabbit anti-Human SerpinC1 Monoclonal Antibody Catalog # MBS2543858 Unit / Price 0.06 mL / $260 +1 FREE 8GB USB 0.12 mL / $380 +1 FREE 8GB USB 0.2 mL / $560 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name SerpinC1, Monoclonal Antibody Full Product Name Rabbit anti Human SerpinC1 Monoclonal Antibody Product Gene Name anti-SerpinC1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM L00185 Genomic DNA Clonality Monoclonal Isotype IgG Host Rabbit Species Reactivity Human Immunogen Recombinant Human Serpin C1 protein Buffer 0.2 mum filtered solution in PBS with 5% trehalose Preparation and Storage This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-SerpinC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-SerpinC1 antibody SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-kappaB activation or actin polymerization. Applications Tested/Suitable for anti-SerpinC1 antibody ELISA (EIA) Application Notes for anti-SerpinC1 antibody ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human SerpinC1. The detection limit for Human SerpinC1 is approximately 0.0049 ng/well. TOP NCBI/Uniprot data below describe general gene information for SerpinC1. It may not necessarily be applicable to this product. NCBI GI # 18490839 NCBI GeneID 462 UniProt Secondary Accession # P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0[Other Products] UniProt Related Accession # P01008[Other Products] Molecular Weight 52,602 Da TOP NCBI Official Full Name SERPINC1 protein NCBI Official Synonym Full Names serpin family C member 1 NCBI Official Symbol SERPINC1 [Similar Products] NCBI Official Synonym Symbols AT3; AT3D; ATIII; THPH7 [Similar Products] NCBI Protein Information antithrombin-III UniProt Protein Name Antithrombin-III UniProt Synonym Protein Names Serpin C1 Protein Family Antithrombin UniProt Gene Name SERPINC1 [Similar Products] UniProt Synonym Gene Names AT3; ATIII [Similar Products] UniProt Entry Name ANT3_HUMAN TOP NCBI Summary for SerpinC1 The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] TOP UniProt Comments for SerpinC1 Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Research Articles on SerpinC1 1. This is the first case of pregnancy related stroke, associated with type-II heparin binding site antithrombin deficiency (c. 391C > T, p.Leu131Phe), that has been reported so far. A genetic analysis of the AT gene (SERPINC1) was performed. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-SerpinC1 antibody Reference Product PubMed Publications PROC antibody >117 publications with SerpinC1 and PROC PLG antibody >58 publications with SerpinC1 and PLG F11 antibody >8 publications with SerpinC1 and F11 FGG antibody >7 publications with SerpinC1 and FGG F10 antibody >4 publications with SerpinC1 and F10 Pathways associated with anti-SerpinC1 antibody Products by Pathway Pathway Diagram Common Pathway Of Fibrin Clot Formation antibodies Common Pathway Of Fibrin Clot Formation Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Complement And Coagulation Cascades Pathway antibodies Complement And Coagulation Cascades Pathway Diagram Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram Glypican 1 Network Pathway antibodies Glypican 1 Network Pathway Diagram Hemostasis Pathway antibodies Hemostasis Pathway Diagram Intrinsic Pathway Of Fibrin Clot Formation antibodies Intrinsic Pathway Of Fibrin Clot Formation Diagram Diseases associated with anti-SerpinC1 antibody Disease Name Pubmed Publications Cardiovascular Diseases Antibodies >4091 publications with SerpinC1 and Cardiovascular Diseases Vascular Diseases Antibodies >3962 publications with SerpinC1 and Vascular Diseases Thrombosis Antibodies >3060 publications with SerpinC1 and Thrombosis Blood Coagulation Disorders Antibodies >2791 publications with SerpinC1 and Blood Coagulation Disorders Antithrombin III Deficiency Antibodies >1949 publications with SerpinC1 and Antithrombin III Deficiency Venous Thrombosis Antibodies >1403 publications with SerpinC1 and Venous Thrombosis Thromboembolism Antibodies >1146 publications with SerpinC1 and Thromboembolism Disseminated Intravascular Coagulation Antibodies >913 publications with SerpinC1 and Disseminated Intravascular Coagulation Heart Diseases Antibodies >826 publications with SerpinC1 and Heart Diseases Inflammation Antibodies >772 publications with SerpinC1 and Inflammation Organs/Tissues associated with anti-SerpinC1 antibody Organ/Tissue Name Pubmed Publications Liver Antibodies >916 publications with SerpinC1 and Liver Kidney Antibodies >415 publications with SerpinC1 and Kidney Lung Antibodies >363 publications with SerpinC1 and Lung Brain Antibodies >259 publications with SerpinC1 and Brain Muscle Antibodies >142 publications with SerpinC1 and Muscle Connective Tissue Antibodies >43 publications with SerpinC1 and Connective Tissue Spleen Antibodies >39 publications with SerpinC1 and Spleen Mammary Gland Antibodies >4 publications with SerpinC1 and Mammary Gland Uncharacterized Tissue Antibodies >1 publications with SerpinC1 and Uncharacterized Tissue TOP