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anti-SerpinD1  antibody :: Rabbit anti-Mouse SerpinD1  Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544485 anti-SerpinD1  antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SerpinD1 , Monoclonal Antibody

 Also Known As   

Rabbit anti Mouse SerpinD1  Monoclonal Antibody

 Product Gene Name   

anti-SerpinD1  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M12849 mRNA
 3D Structure    ModBase 3D Structure for P05546
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Immunogen    Recombinant Mouse SerpinD1 protein
 Buffer    0.2 mum filtered solution in PBS with 5% trehalose
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SerpinD1  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SerpinD1  antibody

   SerpinD1, also known as heparin cofactor II (HCII), is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans (GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and suggest that HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
 Applications Tested/Suitable for anti-SerpinD1  antibody   

ELISA (EIA), Immunoprecipitation (IP)

 Application Notes for anti-SerpinD1  antibody    ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse SerpinD1. The detection limit for Mouse SerpinD1 is approximately 0.0049 ng/well.
IP: 1-4 mug/mg of lysate
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NCBI/Uniprot data below describe general gene information for SerpinD1 . It may not necessarily be applicable to this product.
 NCBI GI #    47678677
 NCBI GeneID    3053
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 UniProt Primary Accession #    P05546 [Other Products]
 UniProt Secondary Accession #    Q6IBZ5; B2RAI1; D3DX34 [Other Products]
 UniProt Related Accession #    P05546 [Other Products]
 Molecular Weight    57,071 Da
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 NCBI Official Full Name    SERPIND1
 NCBI Official Synonym Full Names    serpin family D member 1
 NCBI Official Symbol    SERPIND1 [Similar Products]
 NCBI Official Synonym Symbols   
HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
[Similar Products]
 NCBI Protein Information    heparin cofactor 2
 UniProt Protein Name    Heparin cofactor 2
 UniProt Synonym Protein Names   
Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
 UniProt Gene Name    SERPIND1 [Similar Products]
 UniProt Synonym Gene Names    HCF2; HC-II; HLS2 [Similar Products]
 UniProt Entry Name    HEP2_HUMAN
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 NCBI Summary for SerpinD1     This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
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 UniProt Comments for SerpinD1     SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular region; extracellular space

Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation

Disease: Heparin Cofactor Ii Deficiency
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 Research Articles on SerpinD1     1. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SerpinD1  antibodyPathways associated with anti-SerpinD1  antibody
 Reference Product  PubMed Publications
 PROS1 antibody  >1 publications with SerpinD1  and PROS1
 PROC antibody  >1 publications with SerpinD1  and PROC
 Products by Pathway  Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway Of Fibrin Clot Formation antibodies  Intrinsic Pathway Of Fibrin Clot Formation Diagram
Diseases associated with anti-SerpinD1  antibodyOrgans/Tissues associated with anti-SerpinD1  antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >7 publications with SerpinD1  and Cardiovascular Diseases
 Atherosclerosis Antibodies  >3 publications with SerpinD1  and Atherosclerosis
 Necrosis Antibodies  >2 publications with SerpinD1  and Necrosis
 Myocardial Infarction Antibodies  >1 publications with SerpinD1  and Myocardial Infarction
 Lung Neoplasms Antibodies  >1 publications with SerpinD1  and Lung Neoplasms
 Heart Diseases Antibodies  >1 publications with SerpinD1  and Heart Diseases
 Liver Diseases Antibodies  >1 publications with SerpinD1  and Liver Diseases
 Hyperplasia Antibodies  >1 publications with SerpinD1  and Hyperplasia
 Inflammation Antibodies  >1 publications with SerpinD1  and Inflammation
 Hemolysis Antibodies  >1 publications with SerpinD1  and Hemolysis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with SerpinD1  and Liver
 Vascular Antibodies  >4 publications with SerpinD1  and Vascular
 Lung Antibodies  >2 publications with SerpinD1  and Lung
 Kidney Antibodies  >1 publications with SerpinD1  and Kidney
 Brain Antibodies  >1 publications with SerpinD1  and Brain
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