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anti-SUMO2/3 antibody :: Mouse Small Ubiquitin-Related Modifier 2/3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140368 anti-SUMO2/3 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Small Ubiquitin-Related Modifier 2/3 (SUMO2/3), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Small Ubiquitin-Related Modifier 2/3

 Product Synonym Names    SUMO2/3 Antibody; Small Ubiquitin-Related Modifier 2/3, Mouse Anti Human; Small ubiquitin-related modifier 2; SUMO-2; Ubiquitin-like protein SMT3B; SMT3 homolog 2; Sentrin-2; HSMT3; SUMO-3; SUMO2; SMT3B; SMT3H2; MGC117191
 Product Gene Name   

anti-SUMO2/3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603042
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and k light chain
 Clone Number    PAT10F1AT
 Host    Mouse
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 Purity/Purification    SUMO2/3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile filtered colorless solution.
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 Immunogen    Anti-human SUMO2/3 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human SUMO2 amino acids 1-93 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-SUMO2/3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SUMO2/3 antibody

   Introduction: Small Ubiquitin-like Modifiers (SUMOs) are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. Unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. All SUMO proteins share the conserved ubiquitin domain and the C-terminal diglycine cleavage/attachment site. Human SUMO2, also known as Sentrin2 and SMT3B is synthesized as a 95 amino acid (aa), 11 kDa propeptide that contains a two aa C-terminal prosegment, and an 18 aa N-terminal protein interacting region (aa 33 -50). Following prosegment cleavage, the C-terminal glycine is enzymatically attached to a lysine on a target protein. Human SUMO2 shares 100% sequence identity to SUMO-2 from mouse. SUMO2 also has very high sequence homology to SUMO3 and SUMO4, 86 % and 85%, respectivel
 Product Categories/Family for anti-SUMO2/3 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-SUMO2/3 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-SUMO2/3 antibody    SUMO2/3 antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500.Recommended starting dilution is 1:250.
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NCBI/Uniprot data below describe general gene information for SUMO2/3. It may not necessarily be applicable to this product.
 NCBI GI #    54792071
 NCBI GeneID    6613
 NCBI Accession #    NP_001005849.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005849.1 [Other Products]
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 UniProt Secondary Accession #    P55855; Q32Q42; Q6IPZ6; Q96HK1; B2R4I2 [Other Products]
 UniProt Related Accession #    P61956 [Other Products]
 Molecular Weight    8,111 Da
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 NCBI Official Full Name    small ubiquitin-related modifier 2 isoform b
 NCBI Official Synonym Full Names    small ubiquitin-like modifier 2
 NCBI Official Symbol    SUMO2 [Similar Products]
 NCBI Official Synonym Symbols   
HSMT3; SMT3B; SUMO3; Smt3A; SMT3H2
[Similar Products]
 NCBI Protein Information    small ubiquitin-related modifier 2; SMT3 homolog 2; SMT3 suppressor of mif two 3 homolog 2; sentrin 2; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B
 UniProt Protein Name    Small ubiquitin-related modifier 2
 UniProt Synonym Protein Names   
HSMT3; SMT3 homolog 2; SUMO-3; Sentrin-2; Ubiquitin-like protein SMT3B
 UniProt Gene Name    SUMO2 [Similar Products]
 UniProt Synonym Gene Names    SUMO-2Curated [Similar Products]
 UniProt Entry Name    SUMO2_HUMAN
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 NCBI Summary for SUMO2/3    This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SUMO2/3    SUMO2: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1. Interacts with USP25; the interaction sumoylates USP25. Broadly expressed. Belongs to the ubiquitin family. SUMO subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-like modifier

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: nucleoplasm; PML body; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: protein sumoylation; cellular protein metabolic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; post-translational protein modification
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 Research Articles on SUMO2/3    1. Data indicate the identification of 1,002 small ubiquitin-like modifier 2 protein SUMO2T90K modified sites in cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SUMO2/3 antibodyPathways associated with anti-SUMO2/3 antibody
 Reference Product  PubMed Publications
 PML antibody  >26 publications with SUMO2/3 and PML
 SENP1 antibody  >20 publications with SUMO2/3 and SENP1
 RANGAP1 antibody  >16 publications with SUMO2/3 and RANGAP1
 PIAS1 antibody  >9 publications with SUMO2/3 and PIAS1
 PIAS4 antibody  >8 publications with SUMO2/3 and PIAS4
 RANBP2 antibody  >8 publications with SUMO2/3 and RANBP2
 UBE2I antibody  >4 publications with SUMO2/3 and UBE2I
 TP53 antibody  >3 publications with SUMO2/3 and TP53
 TDG antibody  >2 publications with SUMO2/3 and TDG
 PELP1 antibody  >1 publications with SUMO2/3 and PELP1
 Products by Pathway  Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Nuclear Pore Complex Pathway antibodies  Nuclear Pore Complex Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Processing And Activation Of SUMO Pathway antibodies  Processing And Activation Of SUMO Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 SUMO Is Conjugated To E1 (UBA2:SAE1) Pathway antibodies  SUMO Is Conjugated To E1 (UBA2:SAE1) Pathway Diagram
 SUMO Is Proteolytically Processed Pathway antibodies  SUMO Is Proteolytically Processed Pathway Diagram
Diseases associated with anti-SUMO2/3 antibodyOrgans/Tissues associated with anti-SUMO2/3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with SUMO2/3 and Inflammation
 Carcinoma Antibodies  >4 publications with SUMO2/3 and Carcinoma
 Necrosis Antibodies  >4 publications with SUMO2/3 and Necrosis
 Neoplasms, Experimental Antibodies  >3 publications with SUMO2/3 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >3 publications with SUMO2/3 and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with SUMO2/3 and Cell Transformation, Neoplastic
 Prostatic Diseases Antibodies  >3 publications with SUMO2/3 and Prostatic Diseases
 Fibrosis Antibodies  >2 publications with SUMO2/3 and Fibrosis
 Infertility, Male Antibodies  >2 publications with SUMO2/3 and Infertility, Male
 Congenital Abnormalities Antibodies  >2 publications with SUMO2/3 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with SUMO2/3 and Brain
 Blood Antibodies  >19 publications with SUMO2/3 and Blood
 Kidney Antibodies  >9 publications with SUMO2/3 and Kidney
 Liver Antibodies  >8 publications with SUMO2/3 and Liver
 Prostate Antibodies  >6 publications with SUMO2/3 and Prostate
 Heart Antibodies  >5 publications with SUMO2/3 and Heart
 Testis Antibodies  >5 publications with SUMO2/3 and Testis
 Skin Antibodies  >4 publications with SUMO2/3 and Skin
 Muscle Antibodies  >4 publications with SUMO2/3 and Muscle
 Pancreas Antibodies  >2 publications with SUMO2/3 and Pancreas
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