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anti-STMN1 antibody :: Rabbit Stathmin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS302893
Unit / Price
0.1 mL (Concentrate)  /  $270 +1 FREE 8GB USB
7 mL (RTU)  /  $450 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $505 +1 FREE 8GB USB
1 mL (Concentrate)  /  $745 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Stathmin (STMN1), Monoclonal Antibody

 Also Known As   

Rabbit Anti-Human Stathmin Monoclonal Antibody (Clone SP49)

 Product Gene Name   

anti-STMN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151442
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    SP49
 Host    Rabbit
 Species Reactivity    Human, Mouse
Predicted Reactivity: Bovine, Chicken, Dog, Pig, Rat
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 Form/Format    0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from internal region of human stathmin.
 Control Tissue    Tonsil
 Cellular Localization    Cytoplasm
 Entrez Gene Code    3925
 Pathway    Signal Transduction
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-STMN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-STMN1 antibody

   Stathmin is a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.
 Applications Tested/Suitable for anti-STMN1 antibody   

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-STMN1 antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilutions: If using the concentrate format of this product, dilute the antibody 1:100 prior to use. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at room temperature for 20 min. Primary Antibody: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Tonsil, Breast Carcinoma

Western Blot
Recommended Starting Protocol: Dilute the antibody 1:25. Incubate for 1 hour at room temperature. The dilution is an estimate; actual results may differ because of variability in methods and protocols. Optimal dilution and procedure should be determined by the end user.
Western Blot Positive Control: NIH3T3 Cell Lysate

Flow Cytometry
Recommended Starting Protocol: Dilute the antibody 1:100. Incubate for 30 minutes at 4 degree C. The dilution is an estimate; actual results may differ because of variability in methods and protocols. Optimal dilution and procedure should be determined by the end user.
Flow Cytometry Positive Control: HeLa Cell Line
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 Western Blot (WB) of anti-STMN1 antibody    Western Blot analysis of NIH3T3 cell lysate with stathmin antibody
anti-STMN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-STMN1 antibody    Human tonsil stained with anti-stathmin antibody
anti-STMN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS)|Flow cytometric analysis of rabbit anti-Stathmin (SP49) antibody in HeLa (green) compare to negative control of rabbit IgG (blue) of anti-STMN1 antibody    anti-STMN1 antibody Flow Cytometry (FC/FACS)|Flow cytometric analysis of rabbit anti-Stathmin (SP49) antibody in HeLa (green) compare to negative control of rabbit IgG (blue) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for STMN1. It may not necessarily be applicable to this product.
 NCBI GI #    224451142
 NCBI GeneID    3925
 NCBI Accession #    NP_001138926.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145454.2 [Other Products]
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 UniProt Secondary Accession #    A2A2D1; B2R4E7; B7Z8N4; D3DPJ5 [Other Products]
 UniProt Related Accession #    P16949 [Other Products]
 Molecular Weight    18 kDa [Similar Products]
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 NCBI Official Full Name    stathmin isoform b
 NCBI Official Synonym Full Names    stathmin 1
 NCBI Official Symbol    STMN1 [Similar Products]
 NCBI Official Synonym Symbols   
Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215
[Similar Products]
 NCBI Protein Information    stathmin; leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein 19; phosphoprotein p19; prosolin; stathmin 1/oncoprotein 18; transmembrane protein C1orf215
 UniProt Protein Name    Stathmin
 UniProt Synonym Protein Names   
Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17
 Protein Family    Stathmin
 UniProt Gene Name    STMN1 [Similar Products]
 UniProt Synonym Gene Names    C1orf215; LAP18; OP18; Op18; pp19 [Similar Products]
 UniProt Entry Name    STMN1_HUMAN
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 NCBI Summary for STMN1    This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
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 UniProt Comments for STMN1    STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: microtubule; neuron projection; membrane; cytoplasm; intracellular; cytosol

Molecular Function: tubulin binding; signal transducer activity

Biological Process: mitotic spindle organization and biogenesis; axonogenesis; negative regulation of microtubule polymerization; response to virus; microtubule depolymerization; positive regulation of cell motility; brain development; signal transduction; neurite development; regulation of cytoskeleton organization and biogenesis
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 Research Articles on STMN1    1. Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-STMN1 antibodyPathways associated with anti-STMN1 antibody
 Reference Product  PubMed Publications
 TP53 antibody  >5 publications with STMN1 and TP53
 MAPK3 antibody  >3 publications with STMN1 and MAPK3
 ADCYAP1 antibody  >1 publications with STMN1 and ADCYAP1
 CDK1 antibody  >1 publications with STMN1 and CDK1
 AURKB antibody  >1 publications with STMN1 and AURKB
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 RB In Cancer Pathway antibodies  RB In Cancer Pathway Diagram
 Regulation Of Microtubule Cytoskeleton Pathway antibodies  Regulation Of Microtubule Cytoskeleton Pathway Diagram
 Signaling Mediated By P38-gamma And P38-delta Pathway antibodies  Signaling Mediated By P38-gamma And P38-delta Pathway Diagram
Diseases associated with anti-STMN1 antibodyOrgans/Tissues associated with anti-STMN1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >69 publications with STMN1 and Carcinoma
 Adenocarcinoma Antibodies  >29 publications with STMN1 and Adenocarcinoma
 Breast Neoplasms Antibodies  >27 publications with STMN1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >16 publications with STMN1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >16 publications with STMN1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >13 publications with STMN1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >13 publications with STMN1 and Neoplasms, Experimental
 Liver Diseases Antibodies  >12 publications with STMN1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >12 publications with STMN1 and Carcinoma, Hepatocellular
 Prostatic Neoplasms Antibodies  >11 publications with STMN1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with STMN1 and Brain
 Blood Antibodies  >42 publications with STMN1 and Blood
 Nerve Antibodies  >36 publications with STMN1 and Nerve
 Lung Antibodies  >26 publications with STMN1 and Lung
 Liver Antibodies  >20 publications with STMN1 and Liver
 Lymph Node Antibodies  >20 publications with STMN1 and Lymph Node
 Lymph Antibodies  >20 publications with STMN1 and Lymph
 Prostate Antibodies  >16 publications with STMN1 and Prostate
 Bone Antibodies  >10 publications with STMN1 and Bone
 Kidney Antibodies  >7 publications with STMN1 and Kidney
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