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anti-SNCA antibody :: Synuclein, alpha Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS312186 anti-SNCA antibody
Unit / Price
0.2 mL  /  $1,070 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Synuclein, alpha (SNCA), Monoclonal Antibody

 Also Known As   

MAb to Synuclein Alpha

 Product Synonym Names    Monoclonal Antibody to Human Synuclein alpha
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (90645250..90759447, complement). Location: 4q21
 OMIM    127750
 3D Structure    ModBase 3D Structure for P37840
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4D6
 Host    Host: Mouse
Source: Tissue Culture Supernatant
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 Specificity    Synuclein, alpha
Reacts well with alpha-synuclein in Western blots and frozen and formalin-fixed/paraffin-embedded tissue sections. Recognizes human alpha-synuclein. Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD
 Purity/Purification    Protein A chromatography
 Form/Format    Purified, Liquid
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified E. coli produced human alpha-synuclein
 Affinity Constant    Not determined
 Buffer    PBS
 Preservative    No
 Dry Ice Shipment    Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SNCA antibody    Monoclonal Antibodies for Neuroscience
 Applications Tested/Suitable for anti-SNCA antibody   

EIA/ELISA, Immunohistochemistry - Formalin/Paraffin, Western Blot

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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    16356657
 NCBI GeneID    6622
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840; Q4W5L2; Q6QBS3 [Other Products]
 Molecular Weight    14,460 Da [Similar Products]
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 NCBI Official Full Name    synuclein alpha
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4; MGC110988
[Similar Products]
 NCBI Protein Information    alpha-synuclein; OTTHUMP00000161559; OTTHUMP00000161560; OTTHUMP00000161561; OTTHUMP00000218549; OTTHUMP00000218550; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; non-A4 component of amyloid; alpha-synuclein, isoform NACP140; non A-beta component of AD amyloid; non-A beta component of AD amyloid; Parkinson disease (autosomal dominant, Lewy body) 4
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1 [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]
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 UniProt Comments for SNCA    Function: May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Subunit structure: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1

By similarity. Interacts with phospholipase D and histones. Ref.15 Ref.16

Subcellular location: Cytoplasm. Membrane. Nucleus. Cell junction › synapse. Note: Membrane-bound in dopaminergic neurons. Ref.16

Tissue specificity: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.

Domain: The 'non A-beta component of Alzheimer disease amyloid plaque' domain (NAC domain) is involved in fibrils formation. The middle hydrophobic region forms the core of the filaments. The C-terminus may regulate aggregation and determine the diameter of the filaments. Ref.21

Post-translational modification: Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Ref.13 Ref.14 Ref.19Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.Ubiquitinated. The predominant conjugate is the diubiquitinated form

Involvement in disease: Note=Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer disease amyloid plaque, and a major component of Lewy body inclusions. They are also found within Lewy body (LB)-like intraneuronal inclusions, glial inclusions and axonal spheroids in neurodegeneration with brain iron accumulation type 1.Defects in SNCA are the cause of Parkinson disease type 1 (PARK1) [

MIM:168601]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features. Ref.24 Ref.25 Ref.26Defects in SNCA are the cause of Parkinson disease type 4 (PARK4) [

MIM:605543]. A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.Defects in SNCA are the cause of dementia Lewy body (DLB) [

MIM:127750]. A neurodegenerative disorder clinically characterized by mental impairment leading to dementia, parkinsonism, often with fluctuating cognitive function, visual hallucinations, falls, syncopal episodes, and sensitivity to neuroleptic medication. Brainstem or cortical intraneuronal accumulations of aggregated proteins (Lewy bodies) are the only essential pathologic features. Patients may also have hippocampal and neocortical senile plaques, sometimes in sufficient number to fulfill the diagnostic criteria for Alzheimer disease.

Sequence similarities: Belongs to the synuclein family.
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Product References and Citations for anti-SNCA antibody

   • Lucking, C.B., et al., (2000), "Alpha-synuclein and Parkinson's disease", Cell Mol. Life Sci., 57(13-14): 1894-1908.
• Trojanowski, J.Q., et al., (2000), "Fatal attractions of proteins. A comprehensive hypothetical mechanism under
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 Research Articles on SNCA    1. Data suggest that membrane lipid modification in oligodendroglial cells containing SUMO-1 promotes the formation of alpha-synuclein inclusion bodies resembling protein aggregates in neurodegenerative disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 SNCB antibody  >73 publications with SNCA and SNCB
 MAPT antibody  >53 publications with SNCA and MAPT
 SNCAIP antibody  >30 publications with SNCA and SNCAIP
 PARK2 antibody  >21 publications with SNCA and PARK2
 APP antibody  >16 publications with SNCA and APP
 SLC6A3 antibody  >12 publications with SNCA and SLC6A3
 MAPK1 antibody  >5 publications with SNCA and MAPK1
 TOR1A antibody  >4 publications with SNCA and TOR1A
 BAD antibody  >3 publications with SNCA and BAD
 SQSTM1 antibody  >3 publications with SNCA and SQSTM1
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >912 publications with SNCA and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >893 publications with SNCA and Neurodegenerative Diseases
 Parkinsonian Disorders Antibodies  >712 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >647 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >251 publications with SNCA and Lewy Body Disease
 Atrophy Antibodies  >152 publications with SNCA and Atrophy
 Death Antibodies  >152 publications with SNCA and Death
 Nerve Degeneration Antibodies  >151 publications with SNCA and Nerve Degeneration
 Alzheimer Disease Antibodies  >122 publications with SNCA and Alzheimer Disease
 Neoplasms Antibodies  >50 publications with SNCA and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >967 publications with SNCA and Nerve
 Brain Antibodies  >624 publications with SNCA and Brain
 Blood Antibodies  >44 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >26 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >18 publications with SNCA and Kidney
 Eye Antibodies  >7 publications with SNCA and Eye
 Heart Antibodies  >6 publications with SNCA and Heart
 Liver Antibodies  >5 publications with SNCA and Liver
 Bone Antibodies  >5 publications with SNCA and Bone
 Lung Antibodies  >3 publications with SNCA and Lung
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