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anti-TAF15 antibody :: Mouse anti-Human TAF15 RNA Polymerase II, TATA Box Binding Protein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602701 anti-TAF15 antibody
Unit / Price
0.05 mg  /  $350 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TAF15 RNA Polymerase II, TATA Box Binding Protein, Monoclonal Antibody

 Also Known As   

TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68kD (TAF15, RBP56, TAF2N, TAFII68, hTAFII68)

 Product Synonym Names    Anti -TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68kD (TAF15, RBP56, TAF2N, TAFII68, hTAFII68)
 Product Gene Name   

anti-TAF15 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (34136488..34174238). Location: 17q11.1-q11.2
 3D Structure    ModBase 3D Structure for Q86X94
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8C319
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68kD.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
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 Immunogen    Partial sequence of recombinant full-length protein to human TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68kD
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-TAF15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TAF15 antibody

   Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.
 Product Categories/Family for anti-TAF15 antibody    Antibodies; Abs to Enzymes, Polymerase
 Applications Tested/Suitable for anti-TAF15 antibody   

Western Blot (WB)

 Application Notes for anti-TAF15 antibody    Suitable for use in Western Blot.
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NCBI/Uniprot data below describe general gene information for TAF15. It may not necessarily be applicable to this product.
 NCBI GI #    119600533
 NCBI GeneID    8148
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 UniProt Primary Accession #    Q86X94 [Other Products]
 UniProt Related Accession #    Q86X94; Q92804 [Other Products]
 Molecular Weight    61,830 Da [Similar Products]
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 NCBI Official Full Name    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa, isoform CRA_d
 NCBI Official Synonym Full Names    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
 NCBI Official Symbol    TAF15 [Similar Products]
 NCBI Official Synonym Symbols   
Npl3; RBP56; TAF2N; TAFII68; hTAFII68
[Similar Products]
 NCBI Protein Information    TATA-binding protein-associated factor 2N; TAF(II)68; RBP56/CSMF fusion; TBP-associated factor 15; 68 kDa TATA-binding protein-associated factor; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)-associated factor, RNA polymerase II, N, 68kD (RNA-binding protein 56)
 UniProt Protein Name    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
 Protein Family    Transcription initiation factor
 UniProt Gene Name    TAF15 [Similar Products]
 UniProt Entry Name    Q86X94_HUMAN
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 NCBI Summary for TAF15    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. [provided by RefSeq]
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 UniProt Comments for TAF15    TAF15: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. Belongs to the RRM TET family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Oncoprotein; Translation

Chromosomal Location of Human Ortholog: 17q11.1-q11.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; nucleotide binding

Biological Process: positive regulation of transcription, DNA-dependent

Disease: Chondrosarcoma, Extraskeletal Myxoid
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 Research Articles on TAF15    1. Rare translocation t(12;17)(p13;q12), this translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68
 Catalog #  Product Name  Catalog #  Product Name
 MBS9316981  Human TATA-binding protein-associated factor 2N, TAF15 ELISA Kit  MBS602701  TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-associated Factor, 68kD (TAF15, RBP56, TAF2N...
Products associated with anti-TAF15 antibodyPathways associated with anti-TAF15 antibody
 Reference Product  PubMed Publications
 ZNF384 antibody  >4 publications with TAF15 and ZNF384
 TAF7 antibody  >1 publications with TAF15 and TAF7
 TAF5 antibody  >1 publications with TAF15 and TAF5
 SF1 antibody  >1 publications with TAF15 and SF1
 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
Diseases associated with anti-TAF15 antibodyOrgans/Tissues associated with anti-TAF15 antibody
 Disease Name  Pubmed Publications
 CHONDROSARCOMA, EXTRASKELETAL MYXOID Antibodies  >9 publications with TAF15 and CHONDROSARCOMA, EXTRASKELETAL MYXOID
 Cell Transformation, Neoplastic Antibodies  >2 publications with TAF15 and Cell Transformation, Neoplastic
 Neurodegenerative Diseases Antibodies  >1 publications with TAF15 and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >6 publications with TAF15 and Thyroid
 Lymph Antibodies  >1 publications with TAF15 and Lymph
 Lymph Node Antibodies  >1 publications with TAF15 and Lymph Node
 Eye Antibodies  >1 publications with TAF15 and Eye
 Embryonic Tissue Antibodies  >1 publications with TAF15 and Embryonic Tissue
 Stomach Antibodies  >1 publications with TAF15 and Stomach
 Blood Antibodies  >1 publications with TAF15 and Blood
 Muscle Antibodies  >1 publications with TAF15 and Muscle
 Brain Antibodies  >1 publications with TAF15 and Brain
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