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anti-TARDBP antibody :: Mouse TAR DNA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140318 anti-TARDBP antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TAR DNA (TARDBP), Monoclonal Antibody

 Also Known As   

Mouse Anti Human TAR DNA-binding protein 43

 Product Synonym Names    TARDBP Antibody; TAR DNA-binding protein 43, Mouse Anti Human; TAR DNA-binding protein 43; TDP-43; TARDBP; TDP43; ALS10
 Product Gene Name   

anti-TARDBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605078
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    Pk1B8AT
 Host    Mouse
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 Purity/Purification    TARDBP antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile filtered colorless solution.
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 Immunogen    Anti-human TARDBP mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TARDBP amino acids 1-260 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-TARDBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TARDBP antibody

   Introduction: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome which produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor which binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, TARDBP regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
 Product Categories/Family for anti-TARDBP antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-TARDBP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TARDBP antibody    TARDBP antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:1,000~1:2,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:50.
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NCBI/Uniprot data below describe general gene information for TARDBP. It may not necessarily be applicable to this product.
 NCBI GI #    6678271
 NCBI GeneID    23435
 NCBI Accession #    NP_031401.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007375.3 [Other Products]
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 UniProt Secondary Accession #    Q53H27; Q6FI92; Q96DJ0; A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12 [Other Products]
 UniProt Related Accession #    Q13148 [Other Products]
 Molecular Weight    31,808 Da
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 NCBI Official Full Name    TAR DNA-binding protein 43
 NCBI Official Synonym Full Names    TAR DNA binding protein
 NCBI Official Symbol    TARDBP [Similar Products]
 NCBI Official Synonym Symbols   
ALS10; TDP-43
[Similar Products]
 NCBI Protein Information    TAR DNA-binding protein 43; TAR DNA-binding protein-43
 UniProt Protein Name    TAR DNA-binding protein 43
 Protein Family    TAR DNA-binding protein
 UniProt Gene Name    TARDBP [Similar Products]
 UniProt Synonym Gene Names    TDP43; TDP-43 [Similar Products]
 UniProt Entry Name    TADBP_HUMAN
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 NCBI Summary for TARDBP    HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TARDBP    TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; perichromatin fibrils; cytoplasm; nuclear speck; nucleus

Molecular Function: identical protein binding; protein binding; mRNA 3'-UTR binding; RNA binding; double-stranded DNA binding; nucleotide binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; RNA splicing; positive regulation of insulin secretion; positive regulation of transcription from RNA polymerase II promoter; mRNA processing

Disease: Amyotrophic Lateral Sclerosis 10, With Or Without Frontotemporal Dementia
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 Research Articles on TARDBP    1. These findings demonstrate CKII induces polymerization of soluble TDP-43 into filaments and Hsp90 promotes TDP-43 filament depolymerization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TARDBP antibodyDiseases associated with anti-TARDBP antibody
 Reference Product  PubMed Publications
 FUS antibody  >91 publications with TARDBP and FUS
 SOD1 antibody  >79 publications with TARDBP and SOD1
 VCP antibody  >28 publications with TARDBP and VCP
 SQSTM1 antibody  >7 publications with TARDBP and SQSTM1
 ATXN2 antibody  >6 publications with TARDBP and ATXN2
 Disease Name  Pubmed Publications
 Amyotrophic Lateral Sclerosis Antibodies  >198 publications with TARDBP and Amyotrophic Lateral Sclerosis
 Nervous System Diseases Antibodies  >192 publications with TARDBP and Nervous System Diseases
 Brain Diseases Antibodies  >80 publications with TARDBP and Brain Diseases
 Amyotrophic Lateral Sclerosis 10 Antibodies  >37 publications with TARDBP and Amyotrophic Lateral Sclerosis 10
 Disease Models, Animal Antibodies  >16 publications with TARDBP and Disease Models, Animal
 Paralysis Antibodies  >9 publications with TARDBP and Paralysis
 Nerve Degeneration Antibodies  >8 publications with TARDBP and Nerve Degeneration
 Cognition Disorders Antibodies  >5 publications with TARDBP and Cognition Disorders
 Abnormalities, Multiple Antibodies  >4 publications with TARDBP and Abnormalities, Multiple
 Weight Loss Antibodies  >3 publications with TARDBP and Weight Loss
Organs/Tissues associated with anti-TARDBP antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >51 publications with TARDBP and Brain
 Muscle Antibodies  >19 publications with TARDBP and Muscle
 Nerve Antibodies  >17 publications with TARDBP and Nerve
 Blood Antibodies  >14 publications with TARDBP and Blood
 Embryonic Tissue Antibodies  >6 publications with TARDBP and Embryonic Tissue
 Liver Antibodies  >2 publications with TARDBP and Liver
 Bone Antibodies  >2 publications with TARDBP and Bone
 Testis Antibodies  >2 publications with TARDBP and Testis
 Vascular Antibodies  >1 publications with TARDBP and Vascular
 Prostate Antibodies  >1 publications with TARDBP and Prostate
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