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anti-Cacng2 antibody :: Mouse anti-Rat, Mouse TARP Gamma2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS802776
Western Blot (WB)
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TARP Gamma2 (Cacng2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-TARP Gamma2/Stargazin Antibody: Clone S245-1

 Product Synonym Names    CACNG2; Calcium channel voltage dependent gamma subunit 2; CaV gamma 2; Ipr328; MGC123981; MGC138502; MGC138504; Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazin; Stg; Stargazer; TARP
 Product Gene Name   

anti-Cacng2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q71RJ2
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    S245-1
 Host    Mouse
 Species Reactivity    Rat, Mouse
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 Form/Format    Protein G Purified
 Concentration    1mg/mL (lot specific)
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 Certificate of Analysis    1 ug/mL was sufficient for detection of TARP Gamma2/ Stargazin in 20ug of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody
 Immunogen    Fusion protein amino acids 203-323 (Cytoplasmic C-terminus) of rat TARPGamma2
 Storage Buffer    PBS pH7.4, 50% glycerol, 0.09% sodium azide
 Research Area(s)    Neuroscience
Ion Channels
Calcium Channels
Voltage-Gated Calcium Channels
Cell Structure
Post-Synaptic Markers
 Cellular Localization    Membrane
 Gene ID    84347
 Acession Number    NP_445803.1
 Swiss Prot    Q71Rj2
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 Preparation and Storage    -20 degree C/ 1 yr + Avoid freeze/thaw cycle.
Shipping: Cold Packs/ 4 degree C.
 Other Notes    Small volumes of anti-Cacng2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cacng2 antibody

   Background Info: Detects ~36kDa. Does not cross-react with TARPGamma3, TARPGamma4 and TARPGamma8

Scientific Background: Stargazin belongs to a group called voltage gated calcium channels (VGCCs) which are present in most excitable cells. Stargazin is thought to stabilize the calcium channel in an inactivated (closed) state. There are five high voltage activated calcium channel types (L, N, P, Q, and R) and one low voltage activated channel type (T). Each of these channels exists as a heteromultimer of a1, b, a2/ d and g subunits with the voltage activated calcium channel function carried by the a subunits. VGCCs exert spatial and temporal control over cellular calcium concentrations and serve to modulate neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression, and neuronal survival.
 Product Categories/Family for anti-Cacng2 antibody    Neuroscience
 Applications Tested/Suitable for anti-Cacng2 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-Cacng2 antibody    WB: (1:1000); Optimal dilutions for assays should be determined by the user.
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 Western Blot (WB) of anti-Cacng2 antibody    Western Blot analysis of Rat brain lysates showing detection of Stargazin Calcium Channel protein using Mouse Anti-Stargazin Calcium Channel Monoclonal Antibody, Clone S245-1. Primary Antibody: Mouse Anti-Stargazin Calcium Channel Monoclonal Antibody at 1:100, 1:250, 1:500, and 1:1000.
anti-Cacng2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Cacng2. It may not necessarily be applicable to this product.
 NCBI GI #    16758072
 NCBI GeneID    84347
 NCBI Accession #    NP_445803.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053351.1 [Other Products]
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 UniProt Primary Accession #    Q71RJ2 [Other Products]
 UniProt Related Accession #    Q71RJ2 [Other Products]
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 NCBI Official Full Name    voltage-dependent calcium channel gamma-2 subunit
 NCBI Official Synonym Full Names    calcium channel, voltage-dependent, gamma subunit 2
 NCBI Official Symbol    Cacng2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    voltage-dependent calcium channel gamma-2 subunit; TARP gamma-2; transmembrane AMPAR regulatory protein gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit
 UniProt Protein Name    Voltage-dependent calcium channel gamma-2 subunit
 UniProt Synonym Protein Names   
Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2
 Protein Family    Voltage-dependent calcium channel
 UniProt Gene Name    Cacng2 [Similar Products]
 UniProt Synonym Gene Names    TARP gamma-2 [Similar Products]
 UniProt Entry Name    CCG2_RAT
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 NCBI Summary for Cacng2    subunit of voltage-dependent calcium channel; involved in influencing channel properties [RGD, Feb 2006]
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 UniProt Comments for Cacng2    Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Cellular Component: voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; ionotropic glutamate receptor binding; protein binding; calcium channel regulator activity

Biological Process: membrane depolarization; regulation of membrane potential; membrane hyperpolarization; transmission of nerve impulse; neuromuscular junction development; neurological system process
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Product References and Citations for anti-Cacng2 antibody

   1. Gill M.B., et al. (2011) J Neurosci. 31(18): 6928-6938. 2. Yu L. (2011) Neuroscience. 178: 13-20. 3. Steinmetz C.C., Turrigiano G.G. (2010) J Neurosci. 30: 14685-14690. 4. Kato. A.S. et al. (2007) J Neurosci. 27: 4969-4977. 5. Letts V.A., et al. (1998) Nat Genet. 19: 340-34
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 Research Articles on Cacng2    1. elevated S-nitrosylation of stargazin contributes to AMPAR upregulation during cocaine sensitization selectively in the nucleus accumbens shell.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Cacng2 antibodyPathways associated with anti-Cacng2 antibody
 Reference Product  PubMed Publications
 Cacng4 antibody  >4 publications with Cacng2 and Cacng4
 Cacng3 antibody  >2 publications with Cacng2 and Cacng3
 Cacng8 antibody  >1 publications with Cacng2 and Cacng8
 Grin1 antibody  >1 publications with Cacng2 and Grin1
 Gria4 antibody  >1 publications with Cacng2 and Gria4
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Organs/Tissues associated with anti-Cacng2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with Cacng2 and Brain
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