NP_003183.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tubulin-specific chaperone C
NCBI Official Synonym Full Names
tubulin folding cofactor C
NCBI Official Synonym Symbols
NCBI Protein Information
tubulin-specific chaperone C; tubulin-folding cofactor C
UniProt Protein Name
Tubulin-specific chaperone C
UniProt Synonym Protein Names
Tubulin-folding cofactor C
UniProt Synonym Gene Names
UniProt Entry Name
TBCC_HUMAN
NCBI Summary for TBCC
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
UniProt Comments for TBCC
Function: Tubulin-folding protein; involved in the final step of the tubulin folding pathway. Ref.6
Subunit structure: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
Subcellular location: Cytoplasm. Note: Detected predominantly in the photoreceptor connecting cilium. Ref.7
Tissue specificity: Expressed in the retina. Expressed in the rod and cone photoreceptors, extending from the inner segments (IS), through the outer nuclear layer (ONL) and into the synapses in the outer plexiform layer (OPL). Strongly expressed to the photoreceptor connecting cilium at the tips of the IS (at protein level). Ref.7
Sequence similarities: Belongs to the TBCC family.Contains 1 C-CAP/cofactor C-like domain.
Research Articles on TBCC
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Products associated with anti-TBCC antibody
Pathways associated with anti-TBCC antibody
Diseases associated with anti-TBCC antibody
Organs/Tissues associated with anti-TBCC antibody
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