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anti-TBX21 antibody :: Mouse anti-Human TBX21 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632922 anti-TBX21 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TBX21, Monoclonal Antibody

 Also Known As   

TBX21 (T-box Transcription Factor TBX21, T-box Protein 21, Transcription Factor TBLYM, T-cell-specific T-box Transcription Factor T-bet, TBET, TBLYM) (Azide Free)

 Product Synonym Names    Anti -TBX21 (T-box Transcription Factor TBX21, T-box Protein 21, Transcription Factor TBLYM, T-cell-specific T-box Transcription Factor T-bet, TBET, TBLYM) (Azide Free)
 Product Gene Name   

anti-TBX21 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (45810610..45823485). Location: 17q21.32
 3D Structure    ModBase 3D Structure for Q53EK5
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 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    11C854
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human TBX21.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, pH 7.2. Azide free.
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 Immunogen    Partial recombinant protein corresponding to aa387-486 of human TBX21 with a GST tag. The MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TBX21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TBX21 antibody

   This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells
 Product Categories/Family for anti-TBX21 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-TBX21 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-TBX21 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
ELISA: 1ug/ml-3ng/ml
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NCBI/Uniprot data below describe general gene information for TBX21. It may not necessarily be applicable to this product.
 NCBI GI #    7019549
 NCBI GeneID    30009
 NCBI Accession #    NP_037483.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013351.1 [Other Products]
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 UniProt Primary Accession #    Q53EK5 [Other Products]
 UniProt Related Accession #    Q53EK5; Q9UL17 [Other Products]
 Molecular Weight    58,302 Da [Similar Products]
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 NCBI Official Full Name    T-box transcription factor TBX21
 NCBI Official Synonym Full Names    T-box 21
 NCBI Official Symbol    TBX21 [Similar Products]
 NCBI Official Synonym Symbols   
TBET; T-PET; T-bet; TBLYM
[Similar Products]
 NCBI Protein Information    T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet
 UniProt Protein Name    T-box 21 variant
 Protein Family    T-box transcription factor
 UniProt Entry Name    Q53EK5_HUMAN
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 NCBI Summary for TBX21    This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]
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 UniProt Comments for TBX21    TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function: transcription factor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to virus; multicellular organismal development; positive regulation of transcription, DNA-dependent; T cell differentiation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance
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 Research Articles on TBX21    1. The T-bet deficiency and the correlation of GATA-3 expression with the increase of IgE are characteristics of long-lasting asthma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TBX21 antibodyDiseases associated with anti-TBX21 antibody
 Products by Pathway  Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >126 publications with TBX21 and Inflammation
 Hypersensitivity Antibodies  >93 publications with TBX21 and Hypersensitivity
 Disease Models, Animal Antibodies  >87 publications with TBX21 and Disease Models, Animal
 Lung Diseases Antibodies  >84 publications with TBX21 and Lung Diseases
 Asthma Antibodies  >80 publications with TBX21 and Asthma
 Respiratory Hypersensitivity Antibodies  >72 publications with TBX21 and Respiratory Hypersensitivity
 Neoplasms Antibodies  >62 publications with TBX21 and Neoplasms
 Necrosis Antibodies  >39 publications with TBX21 and Necrosis
 Brain Diseases Antibodies  >28 publications with TBX21 and Brain Diseases
 Kidney Diseases Antibodies  >18 publications with TBX21 and Kidney Diseases
Organs/Tissues associated with anti-TBX21 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >64 publications with TBX21 and Spleen
 Lymph Node Antibodies  >24 publications with TBX21 and Lymph Node
 Pancreas Antibodies  >3 publications with TBX21 and Pancreas
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