Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TCF3 rightarrow Monoclonal TCF3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • CRP ELISA Kit
 • transducin-like enhancer of split 3 (E (sp1) homolog, Drosop... ELISA Kit
 • IP-10 (CXCL10) Recombinant Recombinant Protein
 • glycoprotein Ib (platelet), alpha polypeptide (GP1BA) Antibody
 • Neurotrypsin (PRSS12) Antibody
 • ACD ELISA Kit
 • tartrate-resistant acid phosphatase 5b, TRACP-5b ELISA Kit
 • APBA1 Antibody
 • translationally controlled tumor protein (TCTP) ELISA Kit
 • Ajellomyces capsulata PCR Kit
 • ZAK Antibody
 • ANKRD11 Antibody
 • HBmu ELISA Kit
 • Complement C1q like protein 4 (C1QL4) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TCF3 antibody :: Mouse anti-Human TCF3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS850534
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TCF3, Monoclonal Antibody

 Also Known As   

TCF3 Antibody

 Product Synonym Names    E2A; ITF1; VDIR; bHLHb21; MGC129647; MGC129648; TCF3
 Product Gene Name   

anti-TCF3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    147141
Section Bar
 Clonality    Monoclonal
 Clone Number    6B8
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Form/Format    Ascitic fluid containing 0.03% sodium azide.
 Concentration    100ug/100ul (lot specific)
Section Bar
 Immunogen    Ascitic fluid containing 0.03% sodium azide.
 Species    Mouse IgG1
Section Bar
 Preparation and Storage    Store at 4 degree C, for long term storage, store at -20 degree C.
 Other Notes    Small volumes of anti-TCF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-TCF3 antibody

   Background: Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
 Product Categories/Family for anti-TCF3 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-TCF3 antibody   

Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-TCF3 antibody    WB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000
Not yet tested in other applications.
Section Bar
 Testing Data of anti-TCF3 antibody    Figure 1: Western blot analysis using TCF3 mouse mAb against A549 (1), A431 (2), Hela (3), PANC-1 (4) and PC-3 (5) cell lysate.
anti-TCF3 antibody Testing Data image
Section Bar
 Testing Data #2 of anti-TCF3 antibody    Figure 2: Flow cytometric analysis of A549 cells using anti-TCF3 mAb (green) and negative control (purple).
anti-TCF3 antibody Testing Data #2 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TCF3. It may not necessarily be applicable to this product.
 NCBI GI #    209915594
 NCBI GeneID    6929
 NCBI Accession #    NP_001129611.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001136139.2 [Other Products]
Section Bar
 UniProt Secondary Accession #    P15883; Q14208; Q14635; Q14636; Q2TB40; Q9UPI9 [Other Products]
 UniProt Related Accession #    P15923 [Other Products]
 Molecular Weight    67.6kDa
Table BarTOPTable Bar
 NCBI Official Full Name    transcription factor E2-alpha isoform E47
 NCBI Official Synonym Full Names    transcription factor 3
 NCBI Official Symbol    TCF3 [Similar Products]
 NCBI Official Synonym Symbols   
E2A; E47; ITF1; VDIR; TCF-3; bHLHb21
[Similar Products]
 NCBI Protein Information    transcription factor E2-alpha; kappa-E2-binding factor; VDR interacting repressor; transcription factor ITF-1; helix-loop-helix protein HE47; transcription factor 3 variant 3; immunoglobulin transcription factor 1; vitamin D receptor-interacting repressor; class B basic helix-loop-helix protein 21; negative vitamin D response element-binding protein; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
 UniProt Protein Name    Transcription factor E2-alpha
 UniProt Synonym Protein Names   
Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-1
 Protein Family    TCF3 fusion partner
 UniProt Gene Name    TCF3 [Similar Products]
 UniProt Synonym Gene Names    BHLHB21; E2A; ITF1; bHLHb21; TCF-3 [Similar Products]
 UniProt Entry Name    TFE2_HUMAN
Section Bar
 NCBI Summary for TCF3    This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Section Bar
 UniProt Comments for TCF3    E2A: a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.

Protein type: Transcription factor; Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; transcription factor complex; protein complex; nuclear chromatin; cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; bHLH transcription factor binding; mitogen-activated protein kinase kinase kinase binding; chromatin binding; transcription factor binding; transcription factor activity

Biological Process: response to drug; Peyer's patch development; immunoglobulin V(D)J recombination; protein stabilization; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; B cell lineage commitment; T cell differentiation in the thymus; positive regulation of cell cycle; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; muscle cell differentiation; regulation of transcription, DNA-dependent; natural killer cell differentiation; B cell differentiation; positive regulation of B cell proliferation; positive regulation of muscle cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; cell development
Table BarTOPTable Bar
 Research Articles on TCF3    1. results suggest that E2A suppresses CRC cell metastasis, at least partially if not all, by inhibiting YAP expression
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TCF3 antibodyPathways associated with anti-TCF3 antibody
 Reference Product  PubMed Publications
 ID3 antibody  >38 publications with TCF3 and ID3
 ID2 antibody  >35 publications with TCF3 and ID2
 ID1 antibody  >29 publications with TCF3 and ID1
 MYOD1 antibody  >16 publications with TCF3 and MYOD1
 TAL1 antibody  >16 publications with TCF3 and TAL1
 TWIST1 antibody  >14 publications with TCF3 and TWIST1
 VDR antibody  >3 publications with TCF3 and VDR
 HDAC2 antibody  >2 publications with TCF3 and HDAC2
 MYOG antibody  >2 publications with TCF3 and MYOG
 LYL1 antibody  >1 publications with TCF3 and LYL1
 Products by Pathway  Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Myogenesis Pathway antibodies  Myogenesis Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with anti-TCF3 antibodyOrgans/Tissues associated with anti-TCF3 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >241 publications with TCF3 and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >129 publications with TCF3 and Gastrointestinal Diseases
 Inflammation Antibodies  >127 publications with TCF3 and Inflammation
 Pain Antibodies  >118 publications with TCF3 and Pain
 Neoplasm Metastasis Antibodies  >99 publications with TCF3 and Neoplasm Metastasis
 Cardiovascular Diseases Antibodies  >94 publications with TCF3 and Cardiovascular Diseases
 Necrosis Antibodies  >82 publications with TCF3 and Necrosis
 Lung Neoplasms Antibodies  >78 publications with TCF3 and Lung Neoplasms
 Liver Diseases Antibodies  >74 publications with TCF3 and Liver Diseases
 Neoplasms, Experimental Antibodies  >73 publications with TCF3 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >552 publications with TCF3 and Embryonic Tissue
 Blood Antibodies  >440 publications with TCF3 and Blood
 Bone Antibodies  >345 publications with TCF3 and Bone
 Brain Antibodies  >244 publications with TCF3 and Brain
 Bone Marrow Antibodies  >194 publications with TCF3 and Bone Marrow
 Muscle Antibodies  >191 publications with TCF3 and Muscle
 Liver Antibodies  >181 publications with TCF3 and Liver
 Lung Antibodies  >138 publications with TCF3 and Lung
 Skin Antibodies  >132 publications with TCF3 and Skin
 Testis Antibodies  >130 publications with TCF3 and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions