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anti-TFAP2A antibody :: Mouse anti-Human TFAP2A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120100
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFAP2A, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human TFAP2A

 Product Synonym Names    transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP-2; AP2TF; TFAP2; AP-2alpha
 Product Gene Name   

anti-TFAP2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107580
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    959C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-TFAP2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TFAP2A antibody

   AP2-alpha is a 52-kD retinoic acid-inducible and developmentally regulated activator of transcription that binds to a consensus DNA-binding sequence CCCCAGGC in the SV40 and metallothionein (MIM 156350) promoters.[supplied by OMIM] [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-TFAP2A antibody   

Dot Blot (DB), Western Blot (WB), Flow Cytometry (FC/FACS)

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 Quality Control of anti-TFAP2A antibody    Western blot analysis of immunized recombinant protein, using anti-TFAP2A monoclonal antibody.
anti-TFAP2A antibody Quality Control image
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 Quality Control #2 of anti-TFAP2A antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-TFAP2A antibody Quality Control #2 image
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 Western Blot (WB) of anti-TFAP2A antibody    Detection of TFAP2A by Western blot.

Samples: Whole cell lysate from human HEK293 (H, 50 ug) and mouse NIH3T3 (M, 50 ug) cells. [Lot No. 959C2a-1]

Predicted molecular weight: 48 kDa
anti-TFAP2A antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-TFAP2A antibody    HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-TFAP2A mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 959C2a-1]
anti-TFAP2A antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for TFAP2A. It may not necessarily be applicable to this product.
 NCBI GI #    109389359
 NCBI GeneID    7020
 NCBI Accession #    NP_003211.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003220 [Other Products]
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 UniProt Secondary Accession #    Q13777; Q5TAV5; Q8N1C6 [Other Products]
 UniProt Related Accession #    P05549 [Other Products]
 Molecular Weight    47,440 Da
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 NCBI Official Full Name    Homo sapiens transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 NCBI Official Symbol    TFAP2A [Similar Products]
 NCBI Official Synonym Symbols   
AP-2; BOFS; AP2TF; TFAP2; AP-2alpha
[Similar Products]
 NCBI Protein Information    transcription factor AP-2-alpha; AP-2 transcription factor; AP2-alpha; activating enhancer-binding protein 2-alpha; activator protein 2
 UniProt Protein Name    Transcription factor AP-2-alpha
 UniProt Synonym Protein Names   
AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2
 Protein Family    Transcription factor
 UniProt Gene Name    TFAP2A [Similar Products]
 UniProt Entry Name    AP2A_HUMAN
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 NCBI Summary for TFAP2A    The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
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 UniProt Comments for TFAP2A    AP-2 alpha: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A- transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Belongs to the AP-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: nucleoplasm; Golgi apparatus; centrosome; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription coactivator activity; chromatin binding

Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; negative regulation of epidermal growth factor receptor signaling pathway; neural crest cell development; regulation of neuron differentiation; positive regulation of transcription, DNA-dependent; palate development; negative regulation of transcription from RNA polymerase II promoter; embryonic pattern specification; negative regulation of cell proliferation; sympathetic nervous system development; sensory perception of sound; oculomotor nerve formation; positive regulation of neuron apoptosis; epidermis morphogenesis; regulation of cell differentiation; negative regulation of neuron apoptosis; kidney development; trigeminal nerve development; inner ear morphogenesis; anterior neuropore closure; embryonic cranial skeleton morphogenesis; positive regulation of bone mineralization; embryonic body morphogenesis; forebrain neuron development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of cell migration

Disease: Branchiooculofacial Syndrome
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 Research Articles on TFAP2A    1. AP2-mediated receptor internalization can be dissociated from AP2-mediated chemotaxis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFAP2A antibodyPathways associated with anti-TFAP2A antibody
 Reference Product  PubMed Publications
 SP1 antibody  >264 publications with TFAP2A and SP1
 ERBB2 antibody  >47 publications with TFAP2A and ERBB2
 CITED2 antibody  >14 publications with TFAP2A and CITED2
 YY1 antibody  >13 publications with TFAP2A and YY1
 YBX1 antibody  >7 publications with TFAP2A and YBX1
 VEGFA antibody  >5 publications with TFAP2A and VEGFA
 CITED4 antibody  >3 publications with TFAP2A and CITED4
 CASP6 antibody  >3 publications with TFAP2A and CASP6
 BCL2 antibody  >2 publications with TFAP2A and BCL2
 UBC antibody  >1 publications with TFAP2A and UBC
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
Diseases associated with anti-TFAP2A antibodyOrgans/Tissues associated with anti-TFAP2A antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >138 publications with TFAP2A and Carcinoma
 Skin Diseases Antibodies  >105 publications with TFAP2A and Skin Diseases
 Breast Neoplasms Antibodies  >89 publications with TFAP2A and Breast Neoplasms
 Necrosis Antibodies  >54 publications with TFAP2A and Necrosis
 Adenocarcinoma Antibodies  >53 publications with TFAP2A and Adenocarcinoma
 Nervous System Diseases Antibodies  >42 publications with TFAP2A and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >40 publications with TFAP2A and Craniofacial Abnormalities
 Neoplasms, Experimental Antibodies  >36 publications with TFAP2A and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >34 publications with TFAP2A and Disease Models, Animal
 Lung Diseases Antibodies  >31 publications with TFAP2A and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >144 publications with TFAP2A and Brain
 Bone Antibodies  >125 publications with TFAP2A and Bone
 Embryonic Tissue Antibodies  >103 publications with TFAP2A and Embryonic Tissue
 Liver Antibodies  >89 publications with TFAP2A and Liver
 Vascular Antibodies  >73 publications with TFAP2A and Vascular
 Skin Antibodies  >67 publications with TFAP2A and Skin
 Eye Antibodies  >65 publications with TFAP2A and Eye
 Kidney Antibodies  >64 publications with TFAP2A and Kidney
 Placenta Antibodies  >63 publications with TFAP2A and Placenta
 Nerve Antibodies  >61 publications with TFAP2A and Nerve
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