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anti-TFEB antibody :: Mouse anti-Human TFEB Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS415007
Testing Data
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TFEB, Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-TFEB Antibody

 Product Gene Name   

anti-TFEB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600744
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Anti-TFEB recognizes TFEB expression in Hela whole cell lysate
 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Raised In    Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein TFEB as immunogen.
  Buffer    citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.
 Antibody Type    Primary antibody.
 Immunogen    Recombinant protein corresponding to full length TFEB.
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-TFEB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TFEB antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TFEB antibody    WB: 1:1000 analysis of TFEB expression in Hela whole cell lysate with Anti-TFEB
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 Testing Data of anti-TFEB antibody    anti-TFEB antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TFEB. It may not necessarily be applicable to this product.
 NCBI GI #    268607698
 NCBI GeneID    7942
 NCBI Accession #    NP_009093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007162 [Other Products]
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 UniProt Secondary Accession #    Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8 [Other Products]
 UniProt Related Accession #    P19484 [Other Products]
 Molecular Weight    43,803 Da
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 NCBI Official Full Name    Homo sapiens transcription factor EB (TFEB), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    transcription factor EB
 NCBI Official Symbol    TFEB [Similar Products]
 NCBI Official Synonym Symbols   
TCFEB; BHLHE35; ALPHATFEB
[Similar Products]
 NCBI Protein Information    transcription factor EB; T-cell transcription factor EB; class E basic helix-loop-helix protein 35
 UniProt Protein Name    Transcription factor EB
 UniProt Synonym Protein Names   
Class E basic helix-loop-helix protein 35; bHLHe35
 Protein Family    Transcription factor
 UniProt Gene Name    TFEB [Similar Products]
 UniProt Entry Name    TFEB_HUMAN
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 UniProt Comments for TFEB    TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; nucleus

Molecular Function: protein dimerization activity; transcription factor activity

Biological Process: embryonic placenta development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; humoral immune response; positive regulation of autophagy
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Product References and Citations for anti-TFEB antibody

   None
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 Research Articles on TFEB    1. We examined the transcriptional regulation of autophagy and observed a functionally significant physical interaction between TFEB and AR in spinal and bulbar muscular atrophy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFEB antibodyDiseases associated with anti-TFEB antibody
 Reference Product  PubMed Publications
 TFE3 antibody  >69 publications with TFEB and TFE3
 MITF antibody  >46 publications with TFEB and MITF
 TFEC antibody  >18 publications with TFEB and TFEC
 PRCC antibody  >10 publications with TFEB and PRCC
 CTSK antibody  >4 publications with TFEB and CTSK
 WT1 antibody  >2 publications with TFEB and WT1
 SMAD7 antibody  >1 publications with TFEB and SMAD7
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >47 publications with TFEB and Kidney Diseases
 Adenocarcinoma Antibodies  >45 publications with TFEB and Adenocarcinoma
 Nervous System Diseases Antibodies  >21 publications with TFEB and Nervous System Diseases
 Brain Diseases Antibodies  >14 publications with TFEB and Brain Diseases
 Heart Diseases Antibodies  >8 publications with TFEB and Heart Diseases
 Liver Diseases Antibodies  >7 publications with TFEB and Liver Diseases
 Congenital Abnormalities Antibodies  >6 publications with TFEB and Congenital Abnormalities
 Lung Diseases Antibodies  >5 publications with TFEB and Lung Diseases
 Necrosis Antibodies  >5 publications with TFEB and Necrosis
 Inflammation Antibodies  >3 publications with TFEB and Inflammation
Organs/Tissues associated with anti-TFEB antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >50 publications with TFEB and Kidney
 Blood Antibodies  >18 publications with TFEB and Blood
 Muscle Antibodies  >14 publications with TFEB and Muscle
 Brain Antibodies  >12 publications with TFEB and Brain
 Lung Antibodies  >8 publications with TFEB and Lung
 Placenta Antibodies  >8 publications with TFEB and Placenta
 Bone Antibodies  >8 publications with TFEB and Bone
 Eye Antibodies  >5 publications with TFEB and Eye
 Skin Antibodies  >5 publications with TFEB and Skin
 Lymph Antibodies  >3 publications with TFEB and Lymph
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