View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-TFRC antibody :: Rabbit anti-Human TFRC Monoclonal Antibody Catalog # MBS2544144 Unit / Price 0.06 mL / $260 +1 FREE 8GB USB 0.12 mL / $380 +1 FREE 8GB USB 0.2 mL / $560 +1 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name TFRC, Monoclonal Antibody Full Product Name Rabbit anti Human TFRC Monoclonal Antibody Product Gene Name anti-TFRC antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM X01060 mRNA Clonality Monoclonal Isotype IgG Host Rabbit Species Reactivity Human Immunogen Recombinant Human Transferrin Receptor/TFRC/CD71 protein Buffer 0.2 mum filtered solution in PBS with 5% trehalose Preparation and Storage This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-TFRC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-TFRC antibody Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC/CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC/CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC/CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential therapeutic target. Applications Tested/Suitable for anti-TFRC antibody Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP) Application Notes for anti-TFRC antibody IHC-P: 1-10 mug/mLIP: 1-4 mug/mg of lysate TOP NCBI/Uniprot data below describe general gene information for TFRC. It may not necessarily be applicable to this product. NCBI GI # 927928764 NCBI GeneID 7037 NCBI GenBank Nucleotide # NM_001313965.1 [Other Products] UniProt Secondary Accession # Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0[Other Products] UniProt Related Accession # P02786[Other Products] Molecular Weight 84,871 Da TOP NCBI Official Full Name transferrin receptor protein 1 isoform 2 NCBI Official Synonym Full Names transferrin receptor NCBI Official Symbol TFRC [Similar Products] NCBI Official Synonym Symbols T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46 [Similar Products] NCBI Protein Information transferrin receptor protein 1 UniProt Protein Name Transferrin receptor protein 1 UniProt Synonym Protein Names T9; p90; CD_antigen: CD71 Protein Family Transferrin receptor protein UniProt Gene Name TFRC [Similar Products] UniProt Synonym Gene Names TR; TfR; TfR1; Trfr; sTfR [Similar Products] UniProt Entry Name TFR1_HUMAN TOP NCBI Summary for TFRC This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] TOP UniProt Comments for TFRC TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.Protein type: Cell surface; Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 3q29Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosomeMolecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activityBiological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transportDisease: Immunodeficiency 46 Research Articles on TFRC 1. Data show that the concentration of soluble transferrin receptor with high diagnostic value in the detection of iron deficiency-based anemia in patients undergoing dialysis for chronic renal failure at the end-stage. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-TFRC antibody Reference Product PubMed Publications HFE antibody >24 publications with TFRC and HFE B2M antibody >18 publications with TFRC and B2M SLC40A1 antibody >14 publications with TFRC and SLC40A1 MYC antibody >14 publications with TFRC and MYC FTH1 antibody >5 publications with TFRC and FTH1 STEAP3 antibody >4 publications with TFRC and STEAP3 UBC antibody >4 publications with TFRC and UBC HIF1A antibody >3 publications with TFRC and HIF1A OPTN antibody >1 publications with TFRC and OPTN Pathways associated with anti-TFRC antibody Products by Pathway Pathway Diagram Cargo Recognition For Clathrin-mediated Endocytosis Pathway antibodies Cargo Recognition For Clathrin-mediated Endocytosis Pathway Diagram Clathrin Derived Vesicle Budding Pathway antibodies Clathrin Derived Vesicle Budding Pathway Diagram Clathrin-mediated Endocytosis Pathway antibodies Clathrin-mediated Endocytosis Pathway Diagram Endocytosis Pathway antibodies Endocytosis Pathway Diagram Endocytosis Pathway antibodies Endocytosis Pathway Diagram FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram Golgi Associated Vesicle Biogenesis Pathway antibodies Golgi Associated Vesicle Biogenesis Pathway Diagram HIF-1 Signaling Pathway antibodies HIF-1 Signaling Pathway Diagram HIF-1-alpha Transcription Factor Network Pathway antibodies HIF-1-alpha Transcription Factor Network Pathway Diagram Hematopoietic Cell Lineage Pathway antibodies Hematopoietic Cell Lineage Pathway Diagram Diseases associated with anti-TFRC antibody Disease Name Pubmed Publications Iron Metabolism Disorders Antibodies >36 publications with TFRC and Iron Metabolism Disorders Anemia Antibodies >26 publications with TFRC and Anemia Disease Models, Animal Antibodies >24 publications with TFRC and Disease Models, Animal Inflammation Antibodies >15 publications with TFRC and Inflammation Anemia, Iron-Deficiency Antibodies >14 publications with TFRC and Anemia, Iron-Deficiency Liver Diseases Antibodies >11 publications with TFRC and Liver Diseases Cardiovascular Diseases Antibodies >10 publications with TFRC and Cardiovascular Diseases Lung Neoplasms Antibodies >10 publications with TFRC and Lung Neoplasms Breast Neoplasms Antibodies >9 publications with TFRC and Breast Neoplasms Colorectal Neoplasms Antibodies >7 publications with TFRC and Colorectal Neoplasms Organs/Tissues associated with anti-TFRC antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >65 publications with TFRC and Blood Brain Antibodies >33 publications with TFRC and Brain Liver Antibodies >32 publications with TFRC and Liver Bone Antibodies >18 publications with TFRC and Bone Intestine Antibodies >16 publications with TFRC and Intestine Lung Antibodies >15 publications with TFRC and Lung Kidney Antibodies >14 publications with TFRC and Kidney Heart Antibodies >10 publications with TFRC and Heart Vascular Antibodies >9 publications with TFRC and Vascular Skin Antibodies >9 publications with TFRC and Skin TOP © 2006-24 MyBioSource.com. 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