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| Product Name
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TG / Thyroglobulin, Monoclonal Antibody
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| Also Known As
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Mouse Monoclonal (IgG2a) to Human TG / Thyroglobulin
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| Product Synonym Names
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Anti-TG / Thyroglobulin Antibody IHC-plus; TG; AITD3; TDH3; Thyroglobulin; TGN; Human TG; Thyroglobulin
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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phenotype 608175
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| 3D Structure
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ModBase 3D Structure for P01266
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| Clonality
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Monoclonal
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| Isotype
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IgG2a
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| Host
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Mouse
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| Species Reactivity
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Bovine, Human
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| Specificity
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Specifically recognizes human thyroglobulin. Does not interfere with anti-thyroglobulin autoantibodies.
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| Purity/Purification
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Protein G Purified
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| Form/Format
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PBS, pH 7.4, 0.1% sodium azide.
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| Concentration
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1 mg/ml (lot specific)
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| Target Species
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Human
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| Immunogen Description
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Thyroglobulin from human thyroid gland.
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| Immunogen Type
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Purified protein
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| Immunogen
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TG / Thyroglobulin antibody was raised against thyroglobulin from human thyroid gland.
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| Preparation and Storage
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Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
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| Other Notes
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Small volumes of anti-TG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Thyroglobulin (TG) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen.
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| Applications Tested/Suitable for anti-TG antibody
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Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
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| Application Notes for anti-TG antibody
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ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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| Immunohistochemistry (IHC) of anti-TG antibody
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Anti-TG / Thyroglobulin antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TOP
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| NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product. |
| NCBI GI #
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55770862
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| NCBI GeneID
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7038
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| NCBI Accession #
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NP_003226.4
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_003235.4
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[Other Products]
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| UniProt Primary Accession #
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P01266
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[Other Products]
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| UniProt Secondary Accession #
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O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3
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[Other Products]
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| UniProt Related Accession #
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P01266
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[Other Products]
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| Molecular Weight
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298,383 Da
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TOP
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| NCBI Official Full Name
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thyroglobulin
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| NCBI Official Synonym Full Names
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thyroglobulin
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| NCBI Official Symbol
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TG
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[Similar Products]
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| NCBI Official Synonym Symbols
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TGN; AITD3
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[Similar Products]
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| NCBI Protein Information
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thyroglobulin
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| UniProt Protein Name
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Thyroglobulin
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| Protein Family
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Thyroglobulin
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| UniProt Gene Name
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TG
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[Similar Products]
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| UniProt Synonym Gene Names
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Tg
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[Similar Products]
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| UniProt Entry Name
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THYG_HUMAN
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| NCBI Summary for TG
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Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
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| UniProt Comments for TG
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TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: extracellular space; extracellular region
Molecular Function: hormone activity
Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process
Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
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TOP
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| Research Articles on TG
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1. We analyzed the influence of postmortem changes on Tg concentration. Tg concentration can increase above the standard value and that a difference between the Tg concentration of RHB and LHB arises as a result of postmortem changes.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with anti-TG antibody | Diseases associated with anti-TG antibody |
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| Organs/Tissues associated with anti-TG antibody |
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TOP
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Antibody 
