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anti-TGFB1 antibody :: Mouse anti-Human TGFB1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS125511
Western Blot (WB)
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGFB1, Monoclonal Antibody

 Also Known As   

TGFB1 Monoclonal Antibody

 Product Synonym Names    TGF-beta: TGF-b
 Product Gene Name   

anti-TGFB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 190180
 3D Structure    ModBase 3D Structure for P01137
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
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 Species    Human
 Immunogen    Recombinant Protein
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 Other Notes    Small volumes of anti-TGFB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TGFB1 antibody    Monoclonal
 Applications Tested/Suitable for anti-TGFB1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

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 Western Blot (WB) of anti-TGFB1 antibody    Western blot analysis of extracts of various cell lines, using TGFB1 antibody.
Secondary antibody: HRP Goat Anti-Mouse IgG (H+L) (MBS128212) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-TGFB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TGFB1. It may not necessarily be applicable to this product.
 NCBI GI #    135674
 NCBI GeneID    7040
 NCBI Accession #    P01137.2 [Other Products]
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 UniProt Primary Accession #    P01137 [Other Products]
 UniProt Secondary Accession #    Q9UCG4; A8K792 [Other Products]
 UniProt Related Accession #    P01137 [Other Products]
 Molecular Weight    390
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 NCBI Official Full Name    Transforming growth factor beta-1
 NCBI Official Synonym Full Names    transforming growth factor, beta 1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Official Synonym Symbols   
CED; LAP; DPD1; TGFB; TGFbeta
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1
 UniProt Protein Name    Transforming growth factor beta-1
 Protein Family    Transforming growth factor
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGFB; TGF-beta-1; LAP [Similar Products]
 UniProt Entry Name    TGFB1_HUMAN
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 NCBI Summary for TGFB1    This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
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 UniProt Comments for TGFB1    TGFB1: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted and stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide (LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1 complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with CD109, DPT and ASPN. Activated in vitro at pH below 3.5 and over 12.5. Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; microvillus; cell soma; Golgi lumen; axon; cytoplasm; plasma membrane; extracellular region; nucleus

Molecular Function: protein binding; enzyme binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; punt binding; cytokine activity; protein N-terminus binding; glycoprotein binding; antigen binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; SMAD protein nuclear translocation; female pregnancy; positive regulation of protein amino acid dephosphorylation; activation of NF-kappaB transcription factor; regulation of protein import into nucleus; positive regulation of MAP kinase activity; connective tissue replacement during inflammatory response; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of ossification; cell cycle arrest; positive regulation of isotype switching to IgA isotypes; inner ear development; regulatory T cell differentiation; positive regulation of interleukin-17 production; response to drug; positive regulation of smooth muscle cell differentiation; positive regulation of chemotaxis; active induction of host immune response by virus; positive regulation of blood vessel endothelial cell migration; regulation of sodium ion transport; negative regulation of blood vessel endothelial cell migration; negative regulation of fat cell differentiation; lymph node development; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; endoderm development; myelination; positive regulation of odontogenesis; negative regulation of phagocytosis; evasion of host defenses by virus; positive regulation of cellular protein metabolic process; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; phosphate metabolic process; negative regulation of cell proliferation; negative regulation of T cell proliferation; ureteric bud development; regulation of DNA binding; negative regulation of release of sequestered calcium ion into cytosol; salivary gland morphogenesis; positive regulation of cell proliferation; protein kinase B signaling cascade; protein export from nucleus; inflammatory response; positive regulation of exit from mitosis; aging; epidermal growth factor receptor signaling pathway; mitotic cell cycle checkpoint; common-partner SMAD protein phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of bone mineralization; positive regulation of peptidyl-serine phosphorylation; SMAD protein complex assembly; positive regulation of protein kinase B signaling cascade; positive regulation of protein complex assembly; positive regulation of protein import into nucleus; response to hypoxia; epithelial to mesenchymal transition; negative regulation of cell growth; negative regulation of cell-cell adhesion; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of skeletal muscle development; mononuclear cell proliferation; protein amino acid phosphorylation; regulation of cell migration; hyaluronan catabolic process; regulation of apoptosis; response to vitamin D; negative regulation of neuroblast proliferation; positive regulation of superoxide release; receptor catabolic process; transforming growth factor beta receptor signaling pathway; germ cell migration; response to glucose stimulus; chondrocyte differentiation; negative regulation of mitotic cell cycle; T cell homeostasis; defense response to fungus, incompatible interaction; cell growth; tolerance induction to self antigen; regulation of striated muscle development; platelet activation; organ regeneration; negative regulation of DNA replication; virus-host interaction; hemopoietic progenitor cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; positive regulation of collagen biosynthetic process; viral infectious cycle; response to estradiol stimulus; negative regulation of cell cycle; positive regulation of histone deacetylation; response to radiation; platelet degranulation; negative regulation of protein amino acid phosphorylation; response to wounding; lipopolysaccharide-mediated signaling pathway; adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; negative regulation of epithelial cell proliferation; intercellular junction assembly and maintenance; regulation of binding; MAPKKK cascade; cellular calcium ion homeostasis; gut development; protein import into nucleus, translocation; ATP biosynthetic process; positive regulation of histone acetylation; positive regulation of protein amino acid phosphorylation; blood coagulation; negative regulation of myoblast differentiation; positive regulation of cell migration

Disease: Cystic Fibrosis; Camurati-engelmann Disease
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 Research Articles on TGFB1    1. They also antagonized the TGF-beta1 induced up-regulation of CTGF and transgelin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFB1 antibodyPathways associated with anti-TGFB1 antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >1336 publications with TGFB1 and SMAD2
 SMAD7 antibody  >540 publications with TGFB1 and SMAD7
 TGFBR3 antibody  >97 publications with TGFB1 and TGFBR3
 DCN antibody  >85 publications with TGFB1 and DCN
 TIMP1 antibody  >77 publications with TGFB1 and TIMP1
 TGFBR2 antibody  >67 publications with TGFB1 and TGFBR2
 TGFBR1 antibody  >61 publications with TGFB1 and TGFBR1
 LTBP1 antibody  >49 publications with TGFB1 and LTBP1
 FN1 antibody  >23 publications with TGFB1 and FN1
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-TGFB1 antibodyOrgans/Tissues associated with anti-TGFB1 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >5055 publications with TGFB1 and Fibrosis
 Lung Diseases Antibodies  >1599 publications with TGFB1 and Lung Diseases
 Liver Cirrhosis Antibodies  >867 publications with TGFB1 and Liver Cirrhosis
 Pulmonary Fibrosis Antibodies  >797 publications with TGFB1 and Pulmonary Fibrosis
 Hypertension Antibodies  >732 publications with TGFB1 and Hypertension
 Proteinuria Antibodies  >503 publications with TGFB1 and Proteinuria
 Diabetic Nephropathies Antibodies  >480 publications with TGFB1 and Diabetic Nephropathies
 Hypersensitivity Antibodies  >456 publications with TGFB1 and Hypersensitivity
 Asthma Antibodies  >424 publications with TGFB1 and Asthma
 Neoplasm Metastasis Antibodies  >391 publications with TGFB1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5513 publications with TGFB1 and Blood
 Muscle Antibodies  >3342 publications with TGFB1 and Muscle
 Kidney Antibodies  >2843 publications with TGFB1 and Kidney
 Bone Antibodies  >2407 publications with TGFB1 and Bone
 Lung Antibodies  >2140 publications with TGFB1 and Lung
 Liver Antibodies  >2027 publications with TGFB1 and Liver
 Connective Tissue Antibodies  >1806 publications with TGFB1 and Connective Tissue
 Heart Antibodies  >1280 publications with TGFB1 and Heart
 Skin Antibodies  >1231 publications with TGFB1 and Skin
 Bone Marrow Antibodies  >822 publications with TGFB1 and Bone Marrow
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