Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TGIF rightarrow Monoclonal TGIF  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PRPS1 Antibody
 • LYPD1 Antibody
 • Monocyte Chemotactic Protein 1 (MCP1) ELISA Kit
 • CD4 Antibody
 • SLC ELISA Kit
 • Putative L-asparaginase  (PF0142) Recombinant Protein
 • Progesterone Receptor Antibody
 • ENDOTHELIN 1 (EDN1) Antibody
 • asymmetrical dimethylarginine, ADMA ELISA Kit
 • FGF7 ELISA Kit
 • Placenta-specific protein 1 (PLAC1) Recombinant Protein
 • Stromal cell derived factor 1-SDF-1 (Cxcl12) ELISA Kit
 • b-Catenin (Tyr-142) (ctnnb1) Antibody
 • Vasodilator Stimulated Phosphoprotein (VASP) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TGIF antibody :: Mouse anti-Human TGIF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120178
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGIF, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human TGIF

 Product Synonym Names    TGFB-induced factor (TALE family homeobox); HPE4; MGC5066; MGC39747
 Product Gene Name   

anti-TGIF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    142946
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    946C1a
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Concentration    100 ug/ml (1.0 ml) (lot specific)
Section Bar
 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
Section Bar
 Other Notes    Small volumes of anti-TGIF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-TGIF antibody

   The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-TGIF antibody   

Dot Blot (DB), Immunocytochemistry (ICC)

Section Bar
 Quality Control of anti-TGIF antibody    Western blot analysis of immunized recombinant protein, using anti-TGIF monoclonal antibody.
anti-TGIF antibody Quality Control image
Section Bar
 Quality Control #2 of anti-TGIF antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-TGIF antibody Quality Control #2 image
Section Bar
 Immunocytochemistry (ICC) of anti-TGIF antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-TGIF mAb. [Lot No. 946C1a-1]
anti-TGIF antibody Immunocytochemistry (ICC) (ICC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TGIF. It may not necessarily be applicable to this product.
 NCBI GI #    522838230
 NCBI GeneID    7050
 NCBI Accession #    NP_733796.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_170695 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6ICR0; Q8N5X9; Q9NRS0; A6NE42; A6NLU7; F8VZB6 [Other Products]
 UniProt Related Accession #    Q15583 [Other Products]
 Molecular Weight    27,715 Da
Table BarTOPTable Bar
 NCBI Official Full Name    Homo sapiens TGFB-induced factor homeobox 1 (TGIF1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    TGFB-induced factor homeobox 1
 NCBI Official Symbol    TGIF1 [Similar Products]
 NCBI Official Synonym Symbols   
HPE4; TGIF
[Similar Products]
 NCBI Protein Information    homeobox protein TGIF1; 5'-TG-3'-interacting factor 1; TALE homeobox TG-interacting factor; transforming growth factor-beta-induced factor
 UniProt Protein Name    Homeobox protein TGIF1
 UniProt Synonym Protein Names   
5'-TG-3'-interacting factor 1
 UniProt Gene Name    TGIF1 [Similar Products]
 UniProt Entry Name    TGIF1_HUMAN
Section Bar
 NCBI Summary for TGIF    The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Section Bar
 UniProt Comments for TGIF    TGIF: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. Defects in TGIF1 are the cause of holoprosencephaly type 4 (HPE4). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the TALE/TGIF homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: nucleoplasm

Molecular Function: protein binding; chromatin binding; transcription factor activity; transcription corepressor activity

Biological Process: response to drug; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of retinoic acid receptor signaling pathway; positive regulation of fibroblast proliferation; dorsal/ventral pattern formation; retina development in camera-type eye; transforming growth factor beta receptor signaling pathway; regulation of gastrulation; neural tube closure; gene expression; determination of left/right symmetry; positive regulation of neuron differentiation

Disease: Holoprosencephaly 4
Table BarTOPTable Bar
 Research Articles on TGIF    1. TG-interacting factor 1 (Tgif1) is an important repressor of SOAT2 gene expression.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TGIF antibodyPathways associated with anti-TGIF antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >18 publications with TGIF and SMAD2
 TGIF2 antibody  >10 publications with TGIF and TGIF2
 SMAD4 antibody  >2 publications with TGIF and SMAD4
 HDAC1 antibody  >2 publications with TGIF and HDAC1
 SIN3A antibody  >1 publications with TGIF and SIN3A
 Products by Pathway  Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
Diseases associated with anti-TGIF antibodyOrgans/Tissues associated with anti-TGIF antibody
 Disease Name  Pubmed Publications
 Holoprosencephaly Antibodies  >34 publications with TGIF and Holoprosencephaly
 Nervous System Diseases Antibodies  >29 publications with TGIF and Nervous System Diseases
 Holoprosencephaly 4 Antibodies  >9 publications with TGIF and Holoprosencephaly 4
 Disease Models, Animal Antibodies  >6 publications with TGIF and Disease Models, Animal
 Brain Diseases Antibodies  >5 publications with TGIF and Brain Diseases
 Liver Neoplasms Antibodies  >3 publications with TGIF and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with TGIF and Liver Diseases
 Inflammation Antibodies  >3 publications with TGIF and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with TGIF and Carcinoma, Hepatocellular
 Necrosis Antibodies  >2 publications with TGIF and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >22 publications with TGIF and Eye
 Brain Antibodies  >18 publications with TGIF and Brain
 Liver Antibodies  >7 publications with TGIF and Liver
 Embryonic Tissue Antibodies  >5 publications with TGIF and Embryonic Tissue
 Blood Antibodies  >4 publications with TGIF and Blood
 Placenta Antibodies  >4 publications with TGIF and Placenta
 Bone Antibodies  >4 publications with TGIF and Bone
 Kidney Antibodies  >4 publications with TGIF and Kidney
 Skin Antibodies  >3 publications with TGIF and Skin
 Connective Tissue Antibodies  >3 publications with TGIF and Connective Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions