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anti-TGM2 antibody :: Mouse anti-Human TGM2 / Transglutaminase 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245288
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TGM2 / Transglutaminase 2, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 2A1] (IgG,k) to Human TGM2 / Transglutaminase 2

 Product Synonym Names    Anti-TGM2 / Transglutaminase 2 Antibody (clone 2A1) IHC-plus; TGM2; G-ALPHA-h; GNAH; TG(C); Transglutaminase 2; Transglutaminase C; TG2; TGase H; TGase-2; TGase-H; Transglutaminase H; TGase C; TGC; TTG; C polypeptide; Tgase II; Tissue transglutaminase; Transglutaminase-2; Human TGM2; Transglutaminase 2
 Product Gene Name   

anti-TGM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190196
 3D Structure    ModBase 3D Structure for P21980
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 Clonality    Monoclonal
 Isotype    IgG,k
 Clone Number    2A1
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Purified
 Form/Format    HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human TGM2 / Transglutaminase 2 purified from E Coli.
 Immunogen Type    Recombinant protein
 Immunogen    TGM2 / Transglutaminase 2 antibody was raised against recombinant human TGM2 / Transglutaminase 2 purified from E Coli.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-TGM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TGM2 antibody

   Transglutaminases (TGases) are calcium-dependent enzymes catalyzing the post-translational cross-linking of proteins.
 Applications Tested/Suitable for anti-TGM2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

 Application Notes for anti-TGM2 antibody    ELISA, IHC-P (10 ug/ml), IP, WB (1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-TGM2 antibody    Anti-TGM2 / Transglutaminase 2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TGM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TGM2 antibody     
anti-TGM2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TGM2. It may not necessarily be applicable to this product.
 NCBI GI #    39777597
 NCBI GeneID    7052
 NCBI Accession #    NP_004604.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004613.2 [Other Products]
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 UniProt Primary Accession #    P21980 [Other Products]
 UniProt Secondary Accession #    Q16436; Q6B838; Q9BTN7; Q9UH35; E1P5V9 [Other Products]
 UniProt Related Accession #    P21980 [Other Products]
 Molecular Weight    38,671 Da
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 NCBI Official Full Name    protein-glutamine gamma-glutamyltransferase 2 isoform a
 NCBI Official Synonym Full Names    transglutaminase 2
 NCBI Official Symbol    TGM2 [Similar Products]
 NCBI Official Synonym Symbols   
TG2; TGC; GNAH; HEL-S-45; G-ALPHA-h
[Similar Products]
 NCBI Protein Information    protein-glutamine gamma-glutamyltransferase 2; TG(C); TGase C; TGase H; TGase-2; TGase-H; transglutaminase C; transglutaminase H; transglutaminase-2; tissue transglutaminase; epididymis secretory protein Li 45; protein-glutamine-gamma-glutamyltransferase; C polypeptide, protein-glutamine-gamma-glutamyltransferase
 UniProt Protein Name    Protein-glutamine gamma-glutamyltransferase 2
 UniProt Synonym Protein Names   
Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2
 Protein Family    Protein-glutamine gamma-glutamyltransferase
 UniProt Gene Name    TGM2 [Similar Products]
 UniProt Synonym Gene Names    TG(C); TGC; TGase C; TGase H; TGase-2 [Similar Products]
 UniProt Entry Name    TGM2_HUMAN
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 NCBI Summary for TGM2    Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TGM2    TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: focal adhesion; mitochondrion; plasma membrane; cytosol

Molecular Function: protein domain specific binding; protein binding; GTP binding; protein-glutamine gamma-glutamyltransferase activity; metal ion binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of cell adhesion; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of apoptosis; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of smooth muscle cell proliferation; blood vessel remodeling; apoptotic cell clearance; protein homooligomerization; elevation of mitochondrial calcium ion concentration; positive regulation of inflammatory response
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 Research Articles on TGM2    1. TGM2 up-regulation along with ITGB1 and SDC4 plays an important role in the development of RCC tumors and advanced RCC with metastasis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGM2 antibodyPathways associated with anti-TGM2 antibody
 Reference Product  PubMed Publications
 ITGB1 antibody  >1 publications with TGM2 and ITGB1
 FN1 antibody  >1 publications with TGM2 and FN1
 Products by Pathway  Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Thromboxane A2 Receptor Signaling Pathway antibodies  Thromboxane A2 Receptor Signaling Pathway Diagram
Diseases associated with anti-TGM2 antibodyOrgans/Tissues associated with anti-TGM2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with TGM2 and Inflammation
 Necrosis Antibodies  >6 publications with TGM2 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with TGM2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >6 publications with TGM2 and Lung Neoplasms
 Fibrosis Antibodies  >5 publications with TGM2 and Fibrosis
 Cardiovascular Diseases Antibodies  >5 publications with TGM2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >5 publications with TGM2 and Breast Neoplasms
 Brain Neoplasms Antibodies  >4 publications with TGM2 and Brain Neoplasms
 Kidney Diseases Antibodies  >4 publications with TGM2 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with TGM2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with TGM2 and Lung
 Brain Antibodies  >10 publications with TGM2 and Brain
 Liver Antibodies  >9 publications with TGM2 and Liver
 Blood Antibodies  >9 publications with TGM2 and Blood
 Eye Antibodies  >7 publications with TGM2 and Eye
 Bone Antibodies  >7 publications with TGM2 and Bone
 Skin Antibodies  >7 publications with TGM2 and Skin
 Connective Tissue Antibodies  >5 publications with TGM2 and Connective Tissue
 Vascular Antibodies  >5 publications with TGM2 and Vascular
 Muscle Antibodies  >5 publications with TGM2 and Muscle
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