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anti-THAP1 antibody :: Mouse anti-Human THAP1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6002395 anti-THAP1 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

THAP1, Monoclonal Antibody

 Also Known As   

THAP1 (THAP Domain-containing Protein 1, 4833431A01Rik, DYT6, FLJ10477, MGC33014)

 Product Synonym Names    Anti -THAP1 (THAP Domain-containing Protein 1, 4833431A01Rik, DYT6, FLJ10477, MGC33014)
 Product Gene Name   

anti-THAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKEWEAAV RRKNFKPTKY SSICSEHFTP DCFKRECNNK LLKENAVPTI FLCTEPHDKK EDLLEPQEQL PPPPLPPPVS QVDAAIGLLM PPLQTPVNLS VFCDHNYTVE DTMHQRKRIH QLEQQVEKLR KKLKTAQQRC RRQERQLEKL KEVVHFQKEK DDVSERGYVI LPNDYFEIVE VPA
 Chromosome Location    Chromosome: 8; NC_000008.10 (42691817..42698474, complement). Location: 8p11.21
 OMIM    602629
 3D Structure    ModBase 3D Structure for Q9NVV9
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 Clonality    Monoclonal
 Isotype    IgG2b,k
 Clone Number    2C1-2F2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human THAP1.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    Full length recombinant corresponding to aa1-214 from human THAP1 (AAH21721) with GST tag. MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-THAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-THAP1 antibody

   DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
 Product Categories/Family for anti-THAP1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-THAP1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-THAP1 antibody    Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
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NCBI/Uniprot data below describe general gene information for THAP1. It may not necessarily be applicable to this product.
 NCBI GI #    40068500
 NCBI GeneID    55145
 NCBI Accession #    NP_945354.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199003.1 [Other Products]
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 UniProt Primary Accession #    Q9NVV9 [Other Products]
 UniProt Secondary Accession #    Q53FQ1; Q6IA99; A6NCB6; D3DSY5; H9KV49 [Other Products]
 UniProt Related Accession #    Q9NVV9 [Other Products]
 Molecular Weight    24,944 Da [Similar Products]
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 NCBI Official Full Name    THAP domain-containing protein 1 isoform 2
 NCBI Official Synonym Full Names    THAP domain containing, apoptosis associated protein 1
 NCBI Official Symbol    THAP1 [Similar Products]
 NCBI Official Synonym Symbols   
DYT6
[Similar Products]
 NCBI Protein Information    THAP domain-containing protein 1; 4833431A01Rik; THAP domain protein 1; nuclear proapoptotic factor
 UniProt Protein Name    THAP domain-containing protein 1
 Protein Family    THAP domain-containing protein
 UniProt Gene Name    THAP1 [Similar Products]
 UniProt Entry Name    THAP1_HUMAN
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 NCBI Summary for THAP1    The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for THAP1    THAP1: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Defects in THAP1 are the cause of dystonia type 6 (DYT6). DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early adulthood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions. Belongs to the THAP1 family.

Protein type: DNA-binding; Transcription factor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: PML body; nucleus

Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; endothelial cell proliferation; regulation of mitotic cell cycle; cell cycle

Disease: Dystonia 6, Torsion
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 Research Articles on THAP1    1. The genotypic spectrum of THAP1 and strengthen the association with upper body involvement, including the cranial and cervical regions that are usually spared in DYT1-primary dystonia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-THAP1 antibodyDiseases associated with anti-THAP1 antibody
 Reference Product  PubMed Publications
 TOR1A antibody  >30 publications with THAP1 and TOR1A
 RRM1 antibody  >3 publications with THAP1 and RRM1
 HCFC1 antibody  >1 publications with THAP1 and HCFC1
 OGT antibody  >1 publications with THAP1 and OGT
 Disease Name  Pubmed Publications
 Dystonia Antibodies  >77 publications with THAP1 and Dystonia
 Dystonic Disorders Antibodies  >47 publications with THAP1 and Dystonic Disorders
 Dystonia 6, torsion Antibodies  >14 publications with THAP1 and Dystonia 6, torsion
 Neoplasms Antibodies  >5 publications with THAP1 and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with THAP1 and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with THAP1 and Learning Disorders
Organs/Tissues associated with anti-THAP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with THAP1 and Brain
 Muscle Antibodies  >13 publications with THAP1 and Muscle
 Blood Antibodies  >3 publications with THAP1 and Blood
 Prostate Antibodies  >2 publications with THAP1 and Prostate
 Vascular Antibodies  >2 publications with THAP1 and Vascular
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