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anti-THOC1 antibody :: Mouse anti-Human THOC1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120309
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

THOC1, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human THOC1

 Product Synonym Names    Homo sapiens THO complex 1; P84; HPR1; P84N5
 Product Gene Name   

anti-THOC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606930
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    3121C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-THOC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-THOC1 antibody

   HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM] [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-THOC1 antibody   

Dot Blot (DB)

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 Quality Control of anti-THOC1 antibody    Western blot analysis of immunized recombinant protein, using anti-THOC1 monoclonal antibody.
anti-THOC1 antibody Quality Control image
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 Quality Control #2 of anti-THOC1 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-THOC1 antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for THOC1. It may not necessarily be applicable to this product.
 NCBI GI #    154448889
 NCBI GeneID    9984
 NCBI Accession #    NP_005122.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005131 [Other Products]
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 UniProt Secondary Accession #    Q15219; Q64I72; Q64I73; B2RBP6 [Other Products]
 UniProt Related Accession #    Q96FV9 [Other Products]
 Molecular Weight    43,359 Da
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 NCBI Official Full Name    Homo sapiens THO complex 1 (THOC1), mRNA
 NCBI Official Synonym Full Names    THO complex 1
 NCBI Official Symbol    THOC1 [Similar Products]
 NCBI Official Synonym Symbols   
P84; HPR1; P84N5
[Similar Products]
 NCBI Protein Information    THO complex subunit 1; hTREX84; nuclear matrix protein p84; tho1
 UniProt Protein Name    THO complex subunit 1
 UniProt Synonym Protein Names   
Nuclear matrix protein p84; p84N5; hTREX84
 UniProt Gene Name    THOC1 [Similar Products]
 UniProt Entry Name    THOC1_HUMAN
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 NCBI Summary for THOC1    HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]
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 UniProt Comments for THOC1    Tho1: a protein associated the nuclear matrix. Part of the TREX (transcription/export) complex. The TREX complex is recruited to transcribed genes and travels with the RNA polymerase during elongation. It may physically link proteins that function in transcription and in RNA export.

Protein type: Spliceosome

Chromosomal Location of Human Ortholog: 18p11.32

Cellular Component: nucleoplasm; intercellular bridge; nuclear matrix; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; DNA binding; RNA binding

Biological Process: negative regulation of isotype switching to IgA isotypes; transcription, DNA-dependent; apoptosis; positive regulation of RNA elongation; RNA splicing; intronless viral mRNA export from host nucleus; signal transduction; replication fork processing; RNA processing; mRNA export from nucleus; regulation of DNA recombination; mRNA processing; regulation of RNA elongation
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 Research Articles on THOC1    1. In humans, high THOC1 protein expression associates with prostate cancer aggressiveness and recurrence. Thus, THOC1 protein is a molecular marker that may improve the identification of aggressive prostate cancers, potentially reducing overtreatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-THOC1 antibodyPathways associated with anti-THOC1 antibody
 Reference Product  PubMed Publications
 THOC5 antibody  >2 publications with THOC1 and THOC5
 THOC6 antibody  >1 publications with THOC1 and THOC6
 THOC2 antibody  >1 publications with THOC1 and THOC2
 THOC7 antibody  >1 publications with THOC1 and THOC7
 Products by Pathway  Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 THC Complex Pathway antibodies  THC Complex Pathway Diagram
 THC Complex Pathway antibodies  THC Complex Pathway Diagram
 TREX Complex Pathway antibodies  TREX Complex Pathway Diagram
 TREX Complex Pathway antibodies  TREX Complex Pathway Diagram
Diseases associated with anti-THOC1 antibodyOrgans/Tissues associated with anti-THOC1 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >4 publications with THOC1 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >4 publications with THOC1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >3 publications with THOC1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with THOC1 and Cell Transformation, Neoplastic
 Pancreatic Neoplasms Antibodies  >2 publications with THOC1 and Pancreatic Neoplasms
 Skin Neoplasms Antibodies  >1 publications with THOC1 and Skin Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with THOC1 and Prostatic Neoplasms
 Infertility, Male Antibodies  >1 publications with THOC1 and Infertility, Male
 Infertility, Female Antibodies  >1 publications with THOC1 and Infertility, Female
 Necrosis Antibodies  >1 publications with THOC1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with THOC1 and Blood
 Lung Antibodies  >3 publications with THOC1 and Lung
 Bone Marrow Antibodies  >2 publications with THOC1 and Bone Marrow
 Embryonic Tissue Antibodies  >2 publications with THOC1 and Embryonic Tissue
 Bone Antibodies  >2 publications with THOC1 and Bone
 Testis Antibodies  >2 publications with THOC1 and Testis
 Kidney Antibodies  >1 publications with THOC1 and Kidney
 Prostate Antibodies  >1 publications with THOC1 and Prostate
 Bladder Antibodies  >1 publications with THOC1 and Bladder
 Liver Antibodies  >1 publications with THOC1 and Liver
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