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anti-THRA antibody :: Mouse anti-Human THRA Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120407
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

THRA, Monoclonal Antibody

 Also Known As   

Mouse monoclonal antibody Anti-Human THRA

 Product Synonym Names    Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), mRNA (cDNA clone MGC:43240 IMAGE:5264048), complete cds.; NR1A1; THRA3; EAR7; ERBA; AR7; EAR-7.1; EAR-7.2; ERB-T-1; ERBA-ALPHA; MGC000261; MGC43240; TR-ALPHA-1; c-ERBA-1; c-ERBA-ALPHA-2
 Product Gene Name   

anti-THRA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    190120
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    948C3a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-THRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-THRA antibody

   The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-THRA antibody   

Dot Blot (DB)

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 Quality Control of anti-THRA antibody    Western blot analysis of immunized recombinant protein, using anti-THRA monoclonal antibody.
anti-THRA antibody Quality Control image
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 Quality Control #2 of anti-THRA antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-THRA antibody Quality Control #2 image
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NCBI/Uniprot data below describe general gene information for THRA. It may not necessarily be applicable to this product.
 NCBI GI #    23243454
 NCBI GeneID    7067
 NCBI Accession #    BC035137 [Other Products]
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 UniProt Secondary Accession #    P21205; Q8N6A1; Q96H73; A8K3B5 [Other Products]
 UniProt Related Accession #    P10827 [Other Products]
 Molecular Weight    50,465 Da
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 NCBI Official Full Name    Homo sapiens thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), mRNA
 NCBI Official Synonym Full Names    thyroid hormone receptor, alpha
 NCBI Official Symbol    THRA [Similar Products]
 NCBI Official Synonym Symbols   
AR7; EAR7; ERBA; CHNG6; ERBA1; NR1A1; THRA1; THRA2; ERB-T-1; c-ERBA-1
[Similar Products]
 NCBI Protein Information    thyroid hormone receptor alpha; EAR-7; ERBA-related 7; V-erbA-related protein 7; c-erbA-alpha; nuclear receptor subfamily 1 group A member 1; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor
 UniProt Protein Name    Thyroid hormone receptor alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group A member 1; V-erbA-related protein 7; EAR-7; c-erbA-1; c-erbA-alpha
 Protein Family    Thyroid hormone receptor
 UniProt Gene Name    THRA [Similar Products]
 UniProt Entry Name    THA_HUMAN
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 NCBI Summary for THRA    The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for THRA    TR-alpha: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Interacts with SRC-3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Four splice variant isoforms have been described.

Protein type: Nuclear receptor; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: protein domain specific binding; protein binding; zinc ion binding; chromatin DNA binding; sequence-specific DNA binding; TATA-binding protein binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription factor binding

Biological Process: transcription from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; transcription initiation from RNA polymerase II promoter; ossification; cytoplasmic sequestering of transcription factor; intracellular receptor-mediated signaling pathway; hormone-mediated signaling; positive regulation of female receptivity; regulation of myeloid cell apoptosis; regulation of lipid catabolic process; regulation of heart contraction; regulation of transcription from RNA polymerase II promoter; female courtship behavior; learning and/or memory; thyroid gland development; erythrocyte differentiation; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; response to cold; negative regulation of transcription, DNA-dependent; cartilage condensation

Disease: Hypothyroidism, Congenital, Nongoitrous, 6
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 Research Articles on THRA    1. A new x-ray crystallographic structure of thyroid hormone receptor ligand-binding domains shows a second binding site for thyroid hormones.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-THRA antibodyPathways associated with anti-THRA antibody
 Reference Product  PubMed Publications
 NCOR1 antibody  >2 publications with THRA and NCOR1
 MED1 antibody  >2 publications with THRA and MED1
 RXRG antibody  >1 publications with THRA and RXRG
 ESR1 antibody  >1 publications with THRA and ESR1
 RXRA antibody  >1 publications with THRA and RXRA
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Thyroid Hormone Signaling Pathway antibodies  Thyroid Hormone Signaling Pathway Diagram
Diseases associated with anti-THRA antibodyOrgans/Tissues associated with anti-THRA antibody
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >22 publications with THRA and Thyroid Diseases
 Cardiovascular Diseases Antibodies  >19 publications with THRA and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >4 publications with THRA and Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with THRA and Kidney Diseases
 Anemia Antibodies  >3 publications with THRA and Anemia
 Goiter Antibodies  >3 publications with THRA and Goiter
 Brain Diseases Antibodies  >3 publications with THRA and Brain Diseases
 Weight Gain Antibodies  >3 publications with THRA and Weight Gain
 Liver Diseases Antibodies  >3 publications with THRA and Liver Diseases
 Necrosis Antibodies  >3 publications with THRA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >67 publications with THRA and Thyroid
 Blood Antibodies  >27 publications with THRA and Blood
 Bone Antibodies  >18 publications with THRA and Bone
 Brain Antibodies  >14 publications with THRA and Brain
 Liver Antibodies  >13 publications with THRA and Liver
 Muscle Antibodies  >6 publications with THRA and Muscle
 Heart Antibodies  >6 publications with THRA and Heart
 Kidney Antibodies  >5 publications with THRA and Kidney
 Ear Antibodies  >4 publications with THRA and Ear
 Eye Antibodies  >4 publications with THRA and Eye
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