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anti-TLR7 antibody :: Mouse anti-Human TLR7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200017
Immunofluorescence (IF)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TLR7, Monoclonal Antibody

 Also Known As   

TLR7 antibody

 Product Synonym Names    toll-like receptor 7; PRO285; UNQ248; tlr 7
 Product Gene Name   

anti-TLR7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF240467 mRNA
 3D Structure    ModBase 3D Structure for Q9NYK1
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    4F4
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human TLR7 (451-500aa) purified from E. coli
 Clone Note    Anti-human TLR7 mAb, clone 4F4, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TLR7 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-TLR7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLR7 antibody

   TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7 (hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7,8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.
 Product Categories/Family for anti-TLR7 antibody    Immunology
 Applications Tested/Suitable for anti-TLR7 antibody   

ELISA (EIA), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-TLR7 antibody    WB: 1:500 ~ 2,000.
Recommended starting dilution is 1:1,000.
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 Immunofluorescence (IF) of anti-TLR7 antibody    ICC/IF analysis of TLR7 in THP-1 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human TLR7 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
anti-TLR7 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TLR7. It may not necessarily be applicable to this product.
 NCBI GI #    7706093
 NCBI GeneID    51284
 NCBI Accession #    NP_057646 [Other Products]
 NCBI GenBank Nucleotide #    NM_016562.3 [Other Products]
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 UniProt Primary Accession #    Q9NYK1 [Other Products]
 UniProt Secondary Accession #    Q9NR98; D1CS69 [Other Products]
 UniProt Related Accession #    Q9NYK1 [Other Products]
 Molecular Weight    120,922 Da
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 NCBI Official Full Name    toll-like receptor 7
 NCBI Official Synonym Full Names    toll like receptor 7
 NCBI Official Symbol    TLR7 [Similar Products]
 NCBI Official Synonym Symbols   
TLR7-like
[Similar Products]
 NCBI Protein Information    toll-like receptor 7
 UniProt Protein Name    Toll-like receptor 7
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR7 [Similar Products]
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 NCBI Summary for TLR7    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR7    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response ().
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Product References and Citations for anti-TLR7 antibody

   Lee J., et al. (2003) Proc. Natl. Acad. Sci. USA. 100, 6646-6651; Crozat K., et al. (2004) Proc. Natl. Acad. Sci. USA. 101, 6835-6836; Muzio M., et al. (1998) J. Exp. Med. 187, 2097-2101; Horng T., et al. (2002) Nature 420, 329-333
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 Research Articles on TLR7    1. Data suggest a central role of XBP1 in TLR7-induced IFNalpha production and identify XBP1 as a potential novel therapeutic target in IFNalpha-driven autoimmune and inflammatory diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TLR7 antibodyPathways associated with anti-TLR7 antibody
 Reference Product  PubMed Publications
 TLR3 antibody  >715 publications with TLR7 and TLR3
 TLR8 antibody  >614 publications with TLR7 and TLR8
 MYD88 antibody  >336 publications with TLR7 and MYD88
 IRF7 antibody  >91 publications with TLR7 and IRF7
 IRAK2 antibody  >47 publications with TLR7 and IRAK2
 TRAF6 antibody  >41 publications with TLR7 and TRAF6
 UNC93B1 antibody  >38 publications with TLR7 and UNC93B1
 IRAK4 antibody  >32 publications with TLR7 and IRAK4
 IRAK1 antibody  >26 publications with TLR7 and IRAK1
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 Simplified Depiction Of MYD88 Distinct Input-Output Pathway antibodies  Simplified Depiction Of MYD88 Distinct Input-Output Pathway Diagram
 TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway antibodies  TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway Diagram
Diseases associated with anti-TLR7 antibodyOrgans/Tissues associated with anti-TLR7 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >539 publications with TLR7 and Inflammation
 Necrosis Antibodies  >291 publications with TLR7 and Necrosis
 Disease Models, Animal Antibodies  >234 publications with TLR7 and Disease Models, Animal
 Skin Diseases Antibodies  >154 publications with TLR7 and Skin Diseases
 Lung Diseases Antibodies  >125 publications with TLR7 and Lung Diseases
 Liver Diseases Antibodies  >123 publications with TLR7 and Liver Diseases
 Kidney Diseases Antibodies  >71 publications with TLR7 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >56 publications with TLR7 and Cardiovascular Diseases
 Pneumonia Antibodies  >27 publications with TLR7 and Pneumonia
 Heart Diseases Antibodies  >24 publications with TLR7 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >187 publications with TLR7 and Lung
 Lymph Node Antibodies  >114 publications with TLR7 and Lymph Node
 Kidney Antibodies  >100 publications with TLR7 and Kidney
 Brain Antibodies  >84 publications with TLR7 and Brain
 Uterus Antibodies  >19 publications with TLR7 and Uterus
 Pancreas Antibodies  >13 publications with TLR7 and Pancreas
 Placenta Antibodies  >13 publications with TLR7 and Placenta
 Connective Tissue Antibodies  >10 publications with TLR7 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with TLR7 and Uncharacterized Tissue
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