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anti-TNFSF11 antibody :: Mouse anti-Human TNFSF11 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690279 anti-TNFSF11 antibody
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNFSF11, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human TNFSF11

 Product Synonym Names    TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
 Product Gene Name   

anti-TNFSF11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_000013.11 (42562736..42608013). Location: 13q14
 OMIM    259710
 3D Structure    ModBase 3D Structure for O14788
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (5F12)
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    protein G chromatography
 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human TNFSF11 recombinant protein (also called TRANCE).
 Antigen    Human recobinant TNFSF11
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
 Remarks    This antibody was selected for its ability to detect human TNFSF11.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-TNFSF11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFSF11 antibody

   TNF-related activation-induced cytokines (TRANCE), also called RANK Ligand (RANKL, receptor activator of NF-kB ligand), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a member of the TNF superfamily. Mouse and human TRANCE share 85% amino acid sequence identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes.
 Applications Tested/Suitable for anti-TNFSF11 antibody   

Western Blot (WB), Immunohistochemistry (IHC) - Paraffin, Flow Cytometry (FC/FACS)

 Application Notes for anti-TNFSF11 antibody    IHC (paraffin): 1:20-1:100
WB: Use at 1:500-1000
Neutralization of TNFSF11 bioactivity: Yes
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NCBI/Uniprot data below describe general gene information for TNFSF11. It may not necessarily be applicable to this product.
 NCBI GI #    4507595
 NCBI GeneID    8600
 NCBI Accession #    NP_003692.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003701.3 [Other Products]
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 UniProt Primary Accession #    O14788 [Other Products]
 UniProt Secondary Accession #    O14723; Q96Q17; Q9P2Q3 [Other Products]
 UniProt Related Accession #    O14788 [Other Products]
 Molecular Weight    35,478 Da
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 11
 NCBI Official Symbol    TNFSF11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF11 [Similar Products]
 UniProt Synonym Gene Names    OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_HUMAN
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 NCBI Summary for TNFSF11    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFSF11    Function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Ref.7

Subunit structure: Homotrimer

Probable. Interacts with TNFRSF11B. Ref.7

Subcellular location: Isoform 1: Cell membrane; Single-pass type II membrane protein. Isoform 3: Cell membrane; Single-pass type II membrane protein. Isoform 2: Cytoplasm

By similarity. Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted

By similarity.

Tissue specificity: Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid.

Induction: Up-regulated by T-cell receptor stimulation.

Post-translational modification: The soluble form of isoform 1 derives from the membrane form by proteolytic processing

By similarity. The cleavage may be catalyzed by ADAM17.

Involvement in disease: Osteopetrosis, autosomal recessive 2 (OPTB2) [MIM:259710]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Belongs to the tumor necrosis factor family.
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 Research Articles on TNFSF11    1. The RANKL/osteoprotegerin ratio was significantly higher in paroxysmal atrial fibrillation than persistent atrial fibrillation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFSF11 antibodyPathways associated with anti-TNFSF11 antibody
 Reference Product  PubMed Publications
 TNFRSF11B antibody  >2130 publications with TNFSF11 and TNFRSF11B
 TNFRSF11A antibody  >1496 publications with TNFSF11 and TNFRSF11A
 NFATC1 antibody  >307 publications with TNFSF11 and NFATC1
 PTH antibody  >197 publications with TNFSF11 and PTH
 FOS antibody  >190 publications with TNFSF11 and FOS
 IL17A antibody  >70 publications with TNFSF11 and IL17A
 STAT3 antibody  >29 publications with TNFSF11 and STAT3
 IL6 antibody  >26 publications with TNFSF11 and IL6
 IL11 antibody  >19 publications with TNFSF11 and IL11
 IL1B antibody  >1 publications with TNFSF11 and IL1B
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-TNFSF11 antibodyOrgans/Tissues associated with anti-TNFSF11 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1483 publications with TNFSF11 and Necrosis
 Osteoporosis Antibodies  >1028 publications with TNFSF11 and Osteoporosis
 Neoplasms Antibodies  >867 publications with TNFSF11 and Neoplasms
 Inflammation Antibodies  >475 publications with TNFSF11 and Inflammation
 Osteolysis Antibodies  >325 publications with TNFSF11 and Osteolysis
 Cardiovascular Diseases Antibodies  >289 publications with TNFSF11 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >213 publications with TNFSF11 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >146 publications with TNFSF11 and Prostatic Neoplasms
 Alveolar Bone Loss Antibodies  >136 publications with TNFSF11 and Alveolar Bone Loss
 Osteopetrosis Antibodies  >118 publications with TNFSF11 and Osteopetrosis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >709 publications with TNFSF11 and Connective Tissue
 Brain Antibodies  >338 publications with TNFSF11 and Brain
 Liver Antibodies  >101 publications with TNFSF11 and Liver
 Lymph Node Antibodies  >80 publications with TNFSF11 and Lymph Node
 Pancreas Antibodies  >17 publications with TNFSF11 and Pancreas
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