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anti-TNNI3 antibody :: Mouse anti-Human TNNI3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS838761
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TNNI3, Monoclonal Antibody

 Also Known As   

TNNI3 antibody

 Product Synonym Names    Monoclonal TNNI3; Anti-TNNI3; Troponin I Type 3; CMH7; MGC116817; TNNC1; cTnI; TNNI3; TNNI 3; TNNI-3
 Product Gene Name   

anti-TNNI3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6FGX2
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4A3
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    TNNI3 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. TNNI3 is the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues.
 Immunogen    TNNI3 antibody was raised in mouse using a recombinant protein expressed in E Coli corresponding to amino acids 1-210 of human TNNI3 as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNNI3 antibody

   Mouse monoclonal TNNI3 antibody
 Product Categories/Family for anti-TNNI3 antibody    Cardiac Markers
 Applications Tested/Suitable for anti-TNNI3 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-TNNI3 antibody    IHC: 1:50
WB: 1:2000
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 Immunohistochemistry (IHC) of anti-TNNI3 antibody    Immunohistochemical analysis of TNNI3 protein in paraffin embedded Human pancreas tissue using TNNI3 antibody
anti-TNNI3 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TNNI3 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant TNNI3 protein (Right) or empty vector (Left) detected with TNNI3 antibody
anti-TNNI3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
 NCBI GI #    49456923
 NCBI GeneID    7137
 NCBI Accession #    CAG46782.1 [Other Products]
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 UniProt Primary Accession #    Q6FGX2 [Other Products]
 UniProt Related Accession #    P19429 [Other Products]
 Molecular Weight    24,008 Da
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 NCBI Official Full Name    TNNI3
 NCBI Official Synonym Full Names    troponin I type 3 (cardiac)
 NCBI Official Symbol    TNNI3 [Similar Products]
 NCBI Official Synonym Symbols   
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
[Similar Products]
 NCBI Protein Information    troponin I, cardiac muscle
 UniProt Protein Name    TNNI3 protein
 UniProt Synonym Protein Names   
TNNI3 protein
 Protein Family    Troponin
 UniProt Gene Name    TNNI3 [Similar Products]
 UniProt Entry Name    Q6FGX2_HUMAN
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 NCBI Summary for TNNI3    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNNI3    TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: sarcomere; troponin complex; cytosol

Molecular Function: troponin T binding; protein domain specific binding; troponin C binding; protein binding; metal ion binding; calcium channel inhibitor activity; actin binding; protein kinase binding; calcium-dependent protein binding

Biological Process: cellular calcium ion homeostasis; regulation of smooth muscle contraction; heart contraction; heart development; regulation of systemic arterial blood pressure by ischemic conditions; ventricular cardiac muscle morphogenesis; vasculogenesis; negative regulation of ATPase activity; cardiac muscle contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Familial Restrictive, 1; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Dilated, 2a
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 Research Articles on TNNI3    1. the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNNI3 antibodyPathways associated with anti-TNNI3 antibody
 Reference Product  PubMed Publications
 TNNT2 antibody  >60 publications with TNNI3 and TNNT2
 TPM1 antibody  >35 publications with TNNI3 and TPM1
 TPM3 antibody  >18 publications with TNNI3 and TPM3
 MYH6 antibody  >13 publications with TNNI3 and MYH6
 TNNC1 antibody  >13 publications with TNNI3 and TNNC1
 TNNT3 antibody  >3 publications with TNNI3 and TNNT3
 TNNT1 antibody  >2 publications with TNNI3 and TNNT1
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
Diseases associated with anti-TNNI3 antibodyOrgans/Tissues associated with anti-TNNI3 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >79 publications with TNNI3 and Heart Diseases
 Cardiomyopathies Antibodies  >69 publications with TNNI3 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >27 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >20 publications with TNNI3 and Cardiomyopathy, Dilated
 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies  >9 publications with TNNI3 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
 Cardiomyopathy, Restrictive Antibodies  >9 publications with TNNI3 and Cardiomyopathy, Restrictive
 Nervous System Diseases Antibodies  >5 publications with TNNI3 and Nervous System Diseases
 Fibrosis Antibodies  >5 publications with TNNI3 and Fibrosis
 Hypertension Antibodies  >4 publications with TNNI3 and Hypertension
 Cardiomyopathy, Familial Restrictive, 1 Antibodies  >3 publications with TNNI3 and Cardiomyopathy, Familial Restrictive, 1
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >67 publications with TNNI3 and Heart
 Embryonic Tissue Antibodies  >4 publications with TNNI3 and Embryonic Tissue
 Lung Antibodies  >2 publications with TNNI3 and Lung
 Skin Antibodies  >1 publications with TNNI3 and Skin
 Uterus Antibodies  >1 publications with TNNI3 and Uterus
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