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anti-TPSAB1 antibody :: Mouse TPSAB1 / Mast Cell Tryptase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245244
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TPSAB1 / Mast Cell Tryptase, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone AA1] (IgG1) to Human TPSAB1 / Mast Cell Tryptase

 Product Synonym Names    Anti-TPSAB1 / Mast Cell Tryptase Antibody (clone AA1) IHC-plus; TPSAB1; Alpha tryptase; Mast cell alpha II tryptase; Tryptase alpha-1; Tryptase beta I; Tryptase-III; TPSB1; Tryptase alpha II; TPS1; TPS2; Tryptase beta-1; Tryptase-1; Tryptase-I; Mast cell beta I tryptase; Tryptase alpha/beta 1; Human TPSAB1; Mast Cell Tryptase
 Product Gene Name   

anti-TPSAB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191080
 3D Structure    ModBase 3D Structure for Q15661
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    AA1
 Host    Mouse
 Species Reactivity    Cat, Dog, Human, Monkey, Rat
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 Specificity    Recognizes human mast cell tryptase, both alpha and beta isoforms. Is an excellent marker for mast cells, and does not bind to any other cell type in immunohistology.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, pH 7.4, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Human mast cell tryptase purified from human lung tissue.
 Immunogen Type    Purified protein
 Immunogen    TPSAB1 / Mast Cell Tryptase antibody was raised against human mast cell tryptase purified from human lung tissue.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing. Store undiluted.
 Other Notes    Small volumes of anti-TPSAB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-TPSAB1 antibody    Family: Protease
Subfamily: Serine S1
 Applications Tested/Suitable for anti-TPSAB1 antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-TPSAB1 antibody    ELISA, IHC-Fr, IHC-P (2.5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-TPSAB1 antibody    Anti-TPSAB1 / Mast Cell Tryptase antibody IHC of human breast, mast cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-TPSAB1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TPSAB1. It may not necessarily be applicable to this product.
 NCBI GI #    13775595
 NCBI GeneID    7177
 NCBI Accession #    NP_003285.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003294.3 [Other Products]
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 UniProt Primary Accession #    Q15661 [Other Products]
 UniProt Secondary Accession #    P15157; Q15663; Q6B052; Q9H2Y4; Q9H2Y5; Q9UQI1; D2E6R9; D2E6S1 [Other Products]
 UniProt Related Accession #    Q15661 [Other Products]
 Molecular Weight    29,533 Da
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 NCBI Official Full Name    tryptase alpha/beta-1
 NCBI Official Synonym Full Names    tryptase alpha/beta 1
 NCBI Official Symbol    TPSAB1 [Similar Products]
 NCBI Official Synonym Symbols   
TPS1; TPS2; TPSB1
[Similar Products]
 NCBI Protein Information    tryptase alpha/beta-1; tryptase I; tryptase-1; tryptase-I; tryptase-III; tryptase beta 1; tryptase beta I; tryptase beta-1; tryptase alpha-1; tryptase alpha II; mast cell beta I tryptase; mast cell alpha II tryptase
 UniProt Protein Name    Tryptase alpha/beta-1
 UniProt Synonym Protein Names   
Tryptase I; Tryptase alpha-1
 Protein Family    Tryptase
 UniProt Gene Name    TPSAB1 [Similar Products]
 UniProt Synonym Gene Names    TPS1; TPS2; TPSB1; Tryptase-1 [Similar Products]
 UniProt Entry Name    TRYB1_HUMAN
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 NCBI Summary for TPSAB1    Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TPSAB1    TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; EC 3.4.21.59; Secreted; Protease

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis
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 Research Articles on TPSAB1    1. The best criterion for discriminating IgE- and non IgE-mediated hypersensitivity reactions in anaesthesia was a tryptase value exceeding twice the basal one.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TPSAB1 antibodyPathways associated with anti-TPSAB1 antibody
 Reference Product  PubMed Publications
 TPSB2 antibody  >4 publications with TPSAB1 and TPSB2
 CPA3 antibody  >2 publications with TPSAB1 and CPA3
 RAC1 antibody  >1 publications with TPSAB1 and RAC1
 RAC2 antibody  >1 publications with TPSAB1 and RAC2
 CTSC antibody  >1 publications with TPSAB1 and CTSC
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with anti-TPSAB1 antibodyOrgans/Tissues associated with anti-TPSAB1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >29 publications with TPSAB1 and Inflammation
 Lung Diseases Antibodies  >8 publications with TPSAB1 and Lung Diseases
 Fibrosis Antibodies  >7 publications with TPSAB1 and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with TPSAB1 and Disease Models, Animal
 Necrosis Antibodies  >5 publications with TPSAB1 and Necrosis
 Hyperplasia Antibodies  >4 publications with TPSAB1 and Hyperplasia
 Edema Antibodies  >3 publications with TPSAB1 and Edema
 Heart Diseases Antibodies  >1 publications with TPSAB1 and Heart Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with TPSAB1 and Carcinoma, Squamous Cell
 Kidney Diseases Antibodies  >1 publications with TPSAB1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >22 publications with TPSAB1 and Skin
 Bone Antibodies  >21 publications with TPSAB1 and Bone
 Bone Marrow Antibodies  >20 publications with TPSAB1 and Bone Marrow
 Lung Antibodies  >20 publications with TPSAB1 and Lung
 Connective Tissue Antibodies  >16 publications with TPSAB1 and Connective Tissue
 Intestine Antibodies  >9 publications with TPSAB1 and Intestine
 Nerve Antibodies  >5 publications with TPSAB1 and Nerve
 Stomach Antibodies  >3 publications with TPSAB1 and Stomach
 Kidney Antibodies  >3 publications with TPSAB1 and Kidney
 Testis Antibodies  >2 publications with TPSAB1 and Testis
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