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anti-TREM-1 antibody :: Rat TREM-1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS219612
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TREM-1, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE TREM-1:FITC

 Product Gene Name   

anti-TREM-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JKE2
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    L5-B8.2A12.3A12
 Host    Rat
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 Form/Format    FITC
Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
 Concentration    IgG concentration 0.1mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Preparation
 Immunogen    Mouse TREM-1 Fc fusion protein
Buffer Solution
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-TREM-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TREM-1 antibody

   Rat anti Mouse Trem-1 antibody, clone L5-B8.2A12.3A12 recognizes mouse triggering receptor expressed on myeloid cells 1 (TREM-1), a 30kD member of the immunoglobulin superfamily expressed on neutrophils and a subset of monocytes. TREM-1 is involved in the microbial inflammatory response. It acts in conjunction with the adaptor protein DAP12 to activate neutrophils and monocytes, leading to the secretion of pro-inflammatory mediators and enhancement of the inflammatory response. Microbial infection also induces the release of soluble form of TREM-1 from monocytes, which is reported to act as an inhibitor of TREM-1. TREM-1 mediates the septic shock pathway, and blocking TREM-1 has been reported to reduce inflammation and increase survival in certain models of bacterial infection.
 Applications Tested/Suitable for anti-TREM-1 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-TREM-1 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data of anti-TREM-1 antibody    Staining of J774 cells with Rat anti Mouse TREM-1:Alexa Fluor ?647 (MBS219711A647)
anti-TREM-1 antibody Testing Data image
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 Testing Data of anti-TREM-1 antibody    Staining of J774 cells with Rat anti Mouse TREM-1:Alexa Fluor 488 (MBS219711A488)
anti-TREM-1 antibody Testing Data image
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 Testing Data of anti-TREM-1 antibody    Staining of J774 cells with Rat anti Mouse TREM-1:RPE (MBS224418)
anti-TREM-1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for TREM-1. It may not necessarily be applicable to this product.
 NCBI GI #    10946760
 NCBI GeneID    58217
 NCBI Accession #    NP_067381.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021406.5 [Other Products]
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 UniProt Primary Accession #    Q9JKE2 [Other Products]
 UniProt Secondary Accession #    Q3TAL7 [Other Products]
 UniProt Related Accession #    Q9JKE2 [Other Products]
 Molecular Weight    25,409 Da
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 NCBI Official Full Name    triggering receptor expressed on myeloid cells 1
 NCBI Official Synonym Full Names    triggering receptor expressed on myeloid cells 1
 NCBI Official Symbol    Trem1 [Similar Products]
 NCBI Protein Information    triggering receptor expressed on myeloid cells 1; triggering receptor expressed in monocytes 1
 UniProt Protein Name    Triggering receptor expressed on myeloid cells 1
 UniProt Synonym Protein Names   
CD_antigen: CD354
 UniProt Gene Name    Trem1 [Similar Products]
 UniProt Synonym Gene Names    TREM-1 [Similar Products]
 UniProt Entry Name    TREM1_MOUSE
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 UniProt Comments for TREM-1    TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; cell; integral to membrane

Biological Process: neutrophil chemotaxis; cell migration; cytokine metabolic process; cytokine secretion during immune response; chemokine metabolic process
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 Research Articles on TREM-1    1. TREM-1 is significantly associated with LPS-induced left ventricular systolic dysfunction in BALB/c mice
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TREM-1 antibodyDiseases associated with anti-TREM-1 antibody
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >205 publications with TREM-1 and Inflammation
 Lung Diseases Antibodies  >74 publications with TREM-1 and Lung Diseases
 Pneumonia Antibodies  >64 publications with TREM-1 and Pneumonia
 Respiratory Tract Infections Antibodies  >60 publications with TREM-1 and Respiratory Tract Infections
 Necrosis Antibodies  >59 publications with TREM-1 and Necrosis
 Cardiovascular Diseases Antibodies  >19 publications with TREM-1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >19 publications with TREM-1 and Disease Models, Animal
 Skin Diseases Antibodies  >11 publications with TREM-1 and Skin Diseases
 Kidney Diseases Antibodies  >7 publications with TREM-1 and Kidney Diseases
 Fibrosis Antibodies  >6 publications with TREM-1 and Fibrosis
Organs/Tissues associated with anti-TREM-1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >220 publications with TREM-1 and Blood
 Bone Marrow Antibodies  >8 publications with TREM-1 and Bone Marrow
 Skin Antibodies  >6 publications with TREM-1 and Skin
 Mixed Antibodies  >5 publications with TREM-1 and Mixed
 Embryonic Tissue Antibodies  >3 publications with TREM-1 and Embryonic Tissue
 Spleen Antibodies  >3 publications with TREM-1 and Spleen
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