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anti-TRPM2 antibody :: Mouse TRPM2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS608280 anti-TRPM2 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRPM2, Monoclonal Antibody

★Popular Item★
 Also Known As   

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC

 Product Synonym Names    Anti -TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC
 Product Gene Name   

anti-TRPM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (45773484..45862964). Location: 21q22.3
 OMIM    603749
 3D Structure    ModBase 3D Structure for Q9HCX4
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10F775
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human TrpC7. Species Crossreactivity: mouse and rat
 Purity/Purification    Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthetic peptide corresponding to aa 845-862 of human TRPC7
 Grade    Affinity Purified
 Important Note for small quantities    Liquids: Apparent volume may be reduced due to evaporation. Add buffer to nominal volume and dilute per instructions. During shipment, small volume products may have adhered to the interior surface of the vial. To recover the maximum amount of product,centrifuge the vial lightly for 1-3 minutes and use a fine tipped pipette for removal. To recover the maximum amount of total product, wash the vial with your assay buffer/diluent. Small volumes of product (less than or equal to 25ul) should be diluted for complete product recovery.
Powders: During shipment, small volume products may have adhered to the interior surface of the vial. To recover the maximum amount of product, centrifuge the vial lightly. To recover the maximum amount of total product, wash the vial with your assay buffer/diluent. Small volumes ~25-50ul should be diluted for complete product recovery
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 Preparation and Storage    May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TRPM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TRPM2 antibody

   Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical force.
 Product Categories/Family for anti-TRPM2 antibody    Antibodies; Abs to Receptors, Estrogen
 Applications Tested/Suitable for anti-TRPM2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF)
Other applications not yet tested.

 Application Notes for anti-TRPM2 antibody    Recommended Dilution:

Western Blot: 1ug/ml detects TrpC7 in 10ug of rat brain lyste using goat anti-mouse IgG (HRP) as secondary antibody.
Immunohistochemistry: 0.1-1ug/ml
Immunofluorescence: 1-10ug/ml

Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for TRPM2. It may not necessarily be applicable to this product.
 NCBI GI #    4507689
 NCBI GeneID    7226
 NCBI Accession #    NP_003298.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003307.3 [Other Products]
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 UniProt Primary Accession #    Q9HCX4 [Other Products]
 UniProt Secondary Accession #    Q5KTC2; Q6J3P5; Q96KN6; Q96Q93; D3DSL6 [Other Products]
 UniProt Related Accession #    O94759; Q14DR2; Q5KTC1 [Other Products]
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 NCBI Official Full Name    transient receptor potential cation channel subfamily M member 2
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily M, member 2
 NCBI Official Symbol    TRPM2 [Similar Products]
 NCBI Official Synonym Symbols   
KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily M member 2; LTrpC-2; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential channel 7; long transient receptor potential channel 2; estrogen-responsive element-associated gene 1 protein
 UniProt Protein Name    Transient receptor potential cation channel subfamily M member 2
 UniProt Synonym Protein Names   
Estrogen-responsive element-associated gene 1 protein; Long transient receptor potential channel 2; LTrpC-2; LTrpC2; Transient receptor potential channel 7
 Protein Family    Transient receptor potential cation channel subfamily
 UniProt Gene Name    TRPM2 [Similar Products]
 UniProt Synonym Gene Names    EREG1; KNP3; LTRPC2; TRPC7 [Similar Products]
 UniProt Entry Name    TRPM2_HUMAN
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 NCBI Summary for TRPM2    The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]
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 UniProt Comments for TRPM2    TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Transporter; Channel, calcium

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity

Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport
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 Research Articles on TRPM2    1. Our findings suggest that the elevation of [Na(+)](in) and [Ca(2+)](in) induced ONP apoptosis and altered the expression of TRPM2. Lithium pretreatment attenuated the apoptosis induced by ionic stress.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRPM2 antibodyDiseases associated with anti-TRPM2 antibody
 Reference Product  PubMed Publications
 TRPC6 antibody  >28 publications with TRPM2 and TRPC6
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >381 publications with TRPM2 and Neoplasms
 Neurodegenerative Diseases Antibodies  >123 publications with TRPM2 and Neurodegenerative Diseases
 Cardiovascular Diseases Antibodies  >97 publications with TRPM2 and Cardiovascular Diseases
 Inflammation Antibodies  >92 publications with TRPM2 and Inflammation
 Necrosis Antibodies  >85 publications with TRPM2 and Necrosis
 Breast Neoplasms Antibodies  >59 publications with TRPM2 and Breast Neoplasms
 Endocrine Gland Neoplasms Antibodies  >36 publications with TRPM2 and Endocrine Gland Neoplasms
 Urologic Neoplasms Antibodies  >33 publications with TRPM2 and Urologic Neoplasms
 Liver Diseases Antibodies  >27 publications with TRPM2 and Liver Diseases
 Neoplasm Metastasis Antibodies  >27 publications with TRPM2 and Neoplasm Metastasis
Organs/Tissues associated with anti-TRPM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >367 publications with TRPM2 and Blood
 Brain Antibodies  >251 publications with TRPM2 and Brain
 Prostate Antibodies  >218 publications with TRPM2 and Prostate
 Testis Antibodies  >144 publications with TRPM2 and Testis
 Nerve Antibodies  >117 publications with TRPM2 and Nerve
 Eye Antibodies  >69 publications with TRPM2 and Eye
 Lung Antibodies  >56 publications with TRPM2 and Lung
 Embryonic Tissue Antibodies  >48 publications with TRPM2 and Embryonic Tissue
 Epididymis Antibodies  >48 publications with TRPM2 and Epididymis
 Pancreas Antibodies  >42 publications with TRPM2 and Pancreas
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