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anti-TRPM4 antibody :: Mouse anti-Human TRPM4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS833066
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TRPM4, Monoclonal Antibody

 Also Known As   

TRPM4 antibody

 Product Synonym Names    Monoclonal TRPM4; Anti-TRPM4; Transient Receptor Potential Cation Channel Subfamily M Member 4; FLJ20041; TRPM4B; TRPM4; TRPM 4; TRPM-4
 Product Gene Name   

anti-TRPM4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604559
 3D Structure    ModBase 3D Structure for Q8TD43
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    14C3
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    TRPM4 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhin al cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production.
 Immunogen    TRPM4 antibody was raised in mouse using a protein expressed in 293T cell transfected with human TRPM4 expression vector as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TRPM4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TRPM4 antibody

   Mouse monoclonal TRPM4 antibody
 Product Categories/Family for anti-TRPM4 antibody    Signal Transduction
 Applications Tested/Suitable for anti-TRPM4 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-TRPM4 antibody    IHC: 1:50
WB: 1:1000
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 Immunohistochemistry (IHC) of anti-TRPM4 antibody    Immunohistochemical analysis of TRPM4 protein in paraffin embedded Carcinoma of Human liver tissue using TRPM4 antibody
anti-TRPM4 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-TRPM4 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant TRPM4 protein (Right) or empty vector (Left) detected with TRPM4 antibody
anti-TRPM4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TRPM4. It may not necessarily be applicable to this product.
 NCBI GI #    304766677
 NCBI GeneID    54795
 NCBI Accession #    NP_001182156.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195227.1 [Other Products]
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 UniProt Primary Accession #    Q8TD43 [Other Products]
 UniProt Secondary Accession #    Q7Z5D9; Q96L84; Q9NXV1; A2RU25 [Other Products]
 UniProt Related Accession #    Q8TD43 [Other Products]
 Molecular Weight    118,630 Da
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 NCBI Official Full Name    transient receptor potential cation channel subfamily M member 4 isoform 2
 NCBI Official Synonym Full Names    transient receptor potential cation channel, subfamily M, member 4
 NCBI Official Symbol    TRPM4 [Similar Products]
 NCBI Official Synonym Symbols   
PFHB1B; TRPM4B
[Similar Products]
 NCBI Protein Information    transient receptor potential cation channel subfamily M member 4
 UniProt Protein Name    Transient receptor potential cation channel subfamily M member 4
 UniProt Synonym Protein Names   
Calcium-activated non-selective cation channel 1; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; Melastatin-4
 Protein Family    Transient receptor potential cation channel subfamily
 UniProt Gene Name    TRPM4 [Similar Products]
 UniProt Synonym Gene Names    LTRPC4; hTRPM4; LTrpC-4; LTrpC4 [Similar Products]
 UniProt Entry Name    TRPM4_HUMAN
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 NCBI Summary for TRPM4    The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
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 UniProt Comments for TRPM4    TRPM4: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B). It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrioventricular block causing syncope and sudden death. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: nucleoplasm; Golgi apparatus; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: calmodulin binding; calcium channel activity; calcium activated cation channel activity; ATP binding

Biological Process: vasoconstriction; regulation of membrane potential; protein sumoylation; regulation of T cell cytokine production; positive regulation of cell proliferation; dendritic cell chemotaxis; transmembrane transport

Disease: Progressive Familial Heart Block, Type Ib
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 Research Articles on TRPM4    1. These results showed that the cell surface expression of TRPM4 channels is mediated by 14-3-3gamma binding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TRPM4 antibodyPathways associated with anti-TRPM4 antibody
 Reference Product  PubMed Publications
 TRPC6 antibody  >34 publications with TRPM4 and TRPC6
 TRPC1 antibody  >32 publications with TRPM4 and TRPC1
 TRPC3 antibody  >28 publications with TRPM4 and TRPC3
 TRPV4 antibody  >27 publications with TRPM4 and TRPV4
 TRPV2 antibody  >25 publications with TRPM4 and TRPV2
 TRPV1 antibody  >25 publications with TRPM4 and TRPV1
 TRPV6 antibody  >12 publications with TRPM4 and TRPV6
 TRPV5 antibody  >11 publications with TRPM4 and TRPV5
 ABCC8 antibody  >8 publications with TRPM4 and ABCC8
 VR1 antibody  >1 publications with TRPM4 and VR1
 Products by Pathway  Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-TRPM4 antibodyOrgans/Tissues associated with anti-TRPM4 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >25 publications with TRPM4 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >21 publications with TRPM4 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >11 publications with TRPM4 and Hypertrophy
 Hypertension Antibodies  >10 publications with TRPM4 and Hypertension
 Inflammation Antibodies  >10 publications with TRPM4 and Inflammation
 Edema Antibodies  >9 publications with TRPM4 and Edema
 Necrosis Antibodies  >9 publications with TRPM4 and Necrosis
 Immune System Diseases Antibodies  >7 publications with TRPM4 and Immune System Diseases
 Hyperplasia Antibodies  >2 publications with TRPM4 and Hyperplasia
 Kidney Diseases Antibodies  >2 publications with TRPM4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >62 publications with TRPM4 and Muscle
 Heart Antibodies  >50 publications with TRPM4 and Heart
 Blood Antibodies  >36 publications with TRPM4 and Blood
 Brain Antibodies  >34 publications with TRPM4 and Brain
 Nerve Antibodies  >14 publications with TRPM4 and Nerve
 Kidney Antibodies  >14 publications with TRPM4 and Kidney
 Pancreas Antibodies  >7 publications with TRPM4 and Pancreas
 Bone Antibodies  >7 publications with TRPM4 and Bone
 Prostate Antibodies  >5 publications with TRPM4 and Prostate
 Embryonic Tissue Antibodies  >4 publications with TRPM4 and Embryonic Tissue
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