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anti-TUBB2b antibody :: Mouse anti-Human, Mouse TUBB2b Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200174
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

TUBB2b, Monoclonal Antibody

 Also Known As   

TUBB2b antibody

 Product Synonym Names    bA506K6.1; DKFZp566F223; FLJ98847; MGC8685; Tubulin beta-2B chain; tubulin beta 2B
 Product Gene Name   

anti-TUBB2b antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    BT019930 mRNA
 3D Structure    ModBase 3D Structure for Q9BVA1
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 Clonality    Monoclonal
 Isotype    IgG2a, k
 Clone Number    AT5B3
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human TUBB2b (1-445aa) purified from E. coli
 Clone Note    Anti-human TUBB2b mAb, clone AT5B3, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TUBB2b protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-TUBB2b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TUBB2b antibody

   The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. Multiple beta Tubulin isoforms have been characterized and are expressed in mammalian tissues. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2b is mainly expressed in developing neurons with a dominant expression during the critical steps of corticogenesis. Also, TUBB2B is a new critical gene involved in neuronal migration. It is present in the nuclei and nucleoplasm, Defects in this gene are a cause of asymmetric polymicrogyria.
 Product Categories/Family for anti-TUBB2b antibody    Cytoskeleton
 Applications Tested/Suitable for anti-TUBB2b antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

 Application Notes for anti-TUBB2b antibody    The antibody has been tested by ELISA, Western blot, and Immunofluorescence analyses to assure specificity and reactivity. Since applications vary, however, each investigation should be titrated by a reagent to obtain optimal results.
Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500.
Recommended starting dilution is 1:250
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 Western Blot (WB) of anti-TUBB2b antibody    Cell lysates (35ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human TUBB2b (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
anti-TUBB2b antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-TUBB2b antibody    Immunofluorescence of human SW480 cells stained with monoclonal anti-human TUBB2b antibody (1:250) with Texas Red (Red). Arrow head: Mitotic cell, Arrow: MTOC (microtubule organizing center).
anti-TUBB2b antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for TUBB2b. It may not necessarily be applicable to this product.
 NCBI GI #    29788768
 NCBI GeneID    347733
 NCBI Accession #    NP_821080 [Other Products]
 NCBI GenBank Nucleotide #    NM_178012.4 [Other Products]
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 UniProt Primary Accession #    Q9BVA1 [Other Products]
 UniProt Secondary Accession #    A8K068 [Other Products]
 UniProt Related Accession #    Q9BVA1 [Other Products]
 Molecular Weight    49,953 Da
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 NCBI Official Full Name    tubulin beta-2B chain
 NCBI Official Synonym Full Names    tubulin beta 2B class IIb
 NCBI Official Symbol    TUBB2B [Similar Products]
 NCBI Official Synonym Symbols   
CDCBM7; PMGYSA; bA506K6.1
[Similar Products]
 NCBI Protein Information    tubulin beta-2B chain
 UniProt Protein Name    Tubulin beta-2B chain
 Protein Family    Tubulin
 UniProt Gene Name    TUBB2B [Similar Products]
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 NCBI Summary for TUBB2b    The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
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 UniProt Comments for TUBB2b    Tubulin is the major constituent of microtubules (PubMed:23001566, PubMed:28013290, PubMed:26732629). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (). Plays a critical role in proper axon guidance in both central and peripheral axon tracts (PubMed:23001566). Implicated in neuronal migration (PubMed:19465910).
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Product References and Citations for anti-TUBB2b antibody

   Xavier Hubert Jaglin, et al. (2009) Nat Genet, 41 (6):746-52.; Bouwmeester T, et al. (2004) Nat Cell Bio, 6 (2):97-105.; Modig, C, et al. (1999) Cell Motil Cytoskeleton, 42 (4): 315-330.
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 Research Articles on TUBB2b    1. The TUBB2B mutation described here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and reinforces the sensitivity of the developing cerebellum to microtubule defects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TUBB2b antibodyPathways associated with anti-TUBB2b antibody
 Reference Product  PubMed Publications
 TUBA1A antibody  >21 publications with TUBB2b and TUBA1A
 TUBA8 antibody  >8 publications with TUBB2b and TUBA8
 Products by Pathway  Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies  Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
 Pathogenic Escherichia Coli Infection Pathway antibodies  Pathogenic Escherichia Coli Infection Pathway Diagram
Diseases associated with anti-TUBB2b antibodyOrgans/Tissues associated with anti-TUBB2b antibody
 Disease Name  Pubmed Publications
 Malformations of Cortical Development Antibodies  >25 publications with TUBB2b and Malformations of Cortical Development
 Fibrosis Antibodies  >5 publications with TUBB2b and Fibrosis
 Cognition Disorders Antibodies  >2 publications with TUBB2b and Cognition Disorders
 Neoplasm Metastasis Antibodies  >1 publications with TUBB2b and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1 publications with TUBB2b and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with TUBB2b and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with TUBB2b and Lung Neoplasms
 Learning Disorders Antibodies  >1 publications with TUBB2b and Learning Disorders
 Memory Disorders Antibodies  >1 publications with TUBB2b and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with TUBB2b and Brain
 Ganglia Antibodies  >12 publications with TUBB2b and Ganglia
 Muscle Antibodies  >9 publications with TUBB2b and Muscle
 Nerve Antibodies  >6 publications with TUBB2b and Nerve
 Eye Antibodies  >4 publications with TUBB2b and Eye
 Vascular Antibodies  >2 publications with TUBB2b and Vascular
 Embryonic Tissue Antibodies  >2 publications with TUBB2b and Embryonic Tissue
 Kidney Antibodies  >1 publications with TUBB2b and Kidney
 Intestine Antibodies  >1 publications with TUBB2b and Intestine
 Prostate Antibodies  >1 publications with TUBB2b and Prostate
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