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anti-TNC antibody :: Mouse anti-Human Tenascin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395300 anti-TNC antibody
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tenascin (TNC), Monoclonal Antibody

 Also Known As   

Tenascin

 Product Gene Name   

anti-TNC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (117781854..117880536, complement). Location: 9q33
 OMIM    187380
 3D Structure    ModBase 3D Structure for P24821
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    T2H5
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein A/G Chromatography
 Form/Format    Provided as solution in phosphate buffered saline with 0.08% sodium azide
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 Immunogen    Hybridoma produced by the fusion of splenocytes from mice immunized with protein preparation from a homogenate of a human mammary tumor and mouse myeloma cells.
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 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-TNC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNC antibody

   Tenascin is an extracellular matrix glyoprotein which is found in numerous types of tissues, but most predominately in the nervous system. It has been shown to be upregulated at the edge of healing wounds and in the stroma of many tumors. Three types of tenascin have been identified, tenascin-C, which was the first to be identified, tenascin-R, which is found almost exclusively in the central nervous system, and tenascin-X, a mammalian tenascin found in some connective tissue and around blood vessels.
 Product Categories/Family for anti-TNC antibody    Monoclonal Antibody; Extracellular Matrix
 Applications Tested/Suitable for anti-TNC antibody   

Western Blot (WB), Immunohistochemistry (IHC) Frozen/Paraffin

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NCBI/Uniprot data below describe general gene information for TNC. It may not necessarily be applicable to this product.
 NCBI GI #    153946395
 NCBI GeneID    3371
 NCBI Accession #    NP_002151.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002160.3 [Other Products]
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 UniProt Primary Accession #    P24821 [Other Products]
 UniProt Secondary Accession #    Q14583; Q15567; Q5T7S3; C9IYT7; C9J575; C9J6D9; C9J848 [Other Products]
 UniProt Related Accession #    P24821 [Other Products]
 Molecular Weight    240,853 Da [Similar Products]
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 NCBI Official Full Name    tenascin
 NCBI Official Synonym Full Names    tenascin C
 NCBI Official Symbol    TNC [Similar Products]
 NCBI Official Synonym Symbols   
GP; JI; TN; HXB; GMEM; TN-C; 150-225
[Similar Products]
 NCBI Protein Information    tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; glioma-associated-extracellular matrix antigen
 UniProt Protein Name    Tenascin
 UniProt Synonym Protein Names   
Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C
 Protein Family    Tenascin
 UniProt Gene Name    TNC [Similar Products]
 UniProt Synonym Gene Names    HXB; TN; TN-C [Similar Products]
 UniProt Entry Name    TENA_HUMAN
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 NCBI Summary for TNC    This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
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 UniProt Comments for TNC    Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Subunit structure: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Ref.8

Subcellular location: Secreted › extracellular space › extracellular matrix.

Induction: By TGFB1.

Sequence similarities: Belongs to the tenascin family.Contains 15 EGF-like domains.Contains 1 fibrinogen C-terminal domain.Contains 15 fibronectin type-III domains.
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 Research Articles on TNC    1. High tenascin-C expression is associated with colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNC antibodyPathways associated with anti-TNC antibody
 Reference Product  PubMed Publications
 SRC antibody  >7 publications with TNC and SRC
 SDC4 antibody  >1 publications with TNC and SDC4
 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Non-integrin Membrane-ECM Interactions Pathway antibodies  Non-integrin Membrane-ECM Interactions Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with anti-TNC antibodyOrgans/Tissues associated with anti-TNC antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >118 publications with TNC and Neoplasms
 Heart Diseases Antibodies  >63 publications with TNC and Heart Diseases
 Nervous System Diseases Antibodies  >59 publications with TNC and Nervous System Diseases
 Disease Models, Animal Antibodies  >37 publications with TNC and Disease Models, Animal
 Inflammation Antibodies  >35 publications with TNC and Inflammation
 Brain Diseases Antibodies  >33 publications with TNC and Brain Diseases
 Necrosis Antibodies  >22 publications with TNC and Necrosis
 Breast Neoplasms Antibodies  >17 publications with TNC and Breast Neoplasms
 Drug Toxicity Antibodies  >16 publications with TNC and Drug Toxicity
 Fibrosis Antibodies  >16 publications with TNC and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >585 publications with TNC and Muscle
 Brain Antibodies  >101 publications with TNC and Brain
 Bone Antibodies  >95 publications with TNC and Bone
 Thymus Antibodies  >80 publications with TNC and Thymus
 Embryonic Tissue Antibodies  >43 publications with TNC and Embryonic Tissue
 Lung Antibodies  >31 publications with TNC and Lung
 Connective Tissue Antibodies  >21 publications with TNC and Connective Tissue
 Skin Antibodies  >19 publications with TNC and Skin
 Liver Antibodies  >19 publications with TNC and Liver
 Spinal Cord Antibodies  >15 publications with TNC and Spinal Cord
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