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anti-HSD17B3 antibody :: Mouse Testosterone Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS532104 anti-HSD17B3 antibody
Unit / Price
1 mg  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Testosterone (HSD17B3), Monoclonal Antibody

 Also Known As   

Testosterone antibody

 Product Synonym Names    Monoclonal Testosterone; Anti-Testosterone; Testosterone; Anti Testosterone
 Product Gene Name   

anti-HSD17B3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    264300
 3D Structure    ModBase 3D Structure for P37058
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 Clonality    Monoclonal
 Clone Number    5127425
 Host    Mouse
 Species Reactivity    To be determined by end-user
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 Form/Format    PBS, pH 7.15, with 0.05% NaN3.
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 Biological Significance    Testosterone is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates. In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Testosterone antibody was raised in mouse using 3-CME-Testosterone-BgG as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-HSD17B3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HSD17B3 antibody

   Mouse monoclonal Testosterone antibody
 Product Categories/Family for anti-HSD17B3 antibody    Hormones & Steroids
 Applications Tested/Suitable for anti-HSD17B3 antibody   

User optimized

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NCBI/Uniprot data below describe general gene information for HSD17B3. It may not necessarily be applicable to this product.
 NCBI GI #    4557649
 NCBI GeneID    3293
 NCBI Accession #    NP_000188.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000197.1 [Other Products]
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 UniProt Primary Accession #    P37058 [Other Products]
 UniProt Secondary Accession #    Q5U0Q6 [Other Products]
 UniProt Related Accession #    P37058 [Other Products]
 Molecular Weight    29,109 Da [Similar Products]
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 NCBI Official Full Name    testosterone 17-beta-dehydrogenase 3
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 3
 NCBI Official Symbol    HSD17B3 [Similar Products]
 NCBI Official Synonym Symbols   
EDH17B3; SDR12C2
[Similar Products]
 NCBI Protein Information    testosterone 17-beta-dehydrogenase 3
 UniProt Protein Name    Testosterone 17-beta-dehydrogenase 3
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase type 3; 17-beta-HSD 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase
 Protein Family    Testosterone 17-beta-dehydrogenase
 UniProt Gene Name    HSD17B3 [Similar Products]
 UniProt Synonym Gene Names    EDH17B3; SDR12C2; 17-beta-HSD 3 [Similar Products]
 UniProt Entry Name    DHB3_HUMAN
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 NCBI Summary for HSD17B3    This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HSD17B3    HSD17B3: Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Defects in HSD17B3 are the cause of male pseudohermaphrodism with gynecomastia (MPH). These individuals have unambiguous female external genitalia at birth, but fail to menstruate at the time of expected puberty and instead virilize as evidenced by growth of the phallus. Breast development may or may not take place. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Protein type: Lipid Metabolism - androgen and estrogen; EC 1.1.1.64; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: testosterone 17-beta-dehydrogenase (NADP+) activity

Biological Process: steroid metabolic process; male genitalia development; androgen biosynthetic process

Disease: 17-beta Hydroxysteroid Dehydrogenase Iii Deficiency
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Product References and Citations for anti-HSD17B3 antibody

   Effects of 4-tert-octylphenol on Xenopus tropicalis in a long term exposure; Karen L. Portera, Allen W. Olmstead, David M. Kumsher, William E. Dennis, Robert L. Sprando, Gary W. Holcombe, Joseph J. Korte, Annelie Lindberg-Livingston, Sigmund J. Degitz (Aquatic Toxicology: Volume: 103 Issue: 3-4 Page: 159-169 DOI: 10.1016/j.aquatox.2011.02.019)
Hormone levels in territorial and non-territorial male collared lizards; Troy A. Bairda, Diana K. Hews (Physiology & Behavior: Volume: 92 Issue: 4 Page: 755-763 DOI: 10.1016/j.physbeh.2007.05.069)
Reproductive maturation of the tropical clawed frog: Xenopus tropicalis; Allen W. Olmstead, Joseph J. Korte, Kacie K. Woodis, Blake A. Bennett, Shannon Ostazeski, Sigmund J. Degitz (General and Comparative Endocrinology: Volume: 160 Issue: 2 Page: 117-123 DOI: 10.1016/j.ygcen.2008.10.025)
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 Research Articles on HSD17B3    1. These results suggest that the HSD17B3 G289S polymorphism may be a potential risk modifier for hypospadias.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSD17B3 antibodyPathways associated with anti-HSD17B3 antibody
 Reference Product  PubMed Publications
 CYP17A1 antibody  >29 publications with HSD17B3 and CYP17A1
 HSD3B1 antibody  >15 publications with HSD17B3 and HSD3B1
 CYP19A1 antibody  >14 publications with HSD17B3 and CYP19A1
 HSD17B1 antibody  >9 publications with HSD17B3 and HSD17B1
 SRD5A1 antibody  >9 publications with HSD17B3 and SRD5A1
 CYP11B2 antibody  >6 publications with HSD17B3 and CYP11B2
 HSD3B2 antibody  >6 publications with HSD17B3 and HSD3B2
 CYP11B1 antibody  >5 publications with HSD17B3 and CYP11B1
 UGT2B17 antibody  >3 publications with HSD17B3 and UGT2B17
 POMC antibody  >1 publications with HSD17B3 and POMC
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
Diseases associated with anti-HSD17B3 antibodyOrgans/Tissues associated with anti-HSD17B3 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >24 publications with HSD17B3 and Congenital Abnormalities
 Disorders of Sex Development Antibodies  >22 publications with HSD17B3 and Disorders of Sex Development
 Genital Diseases, Male Antibodies  >17 publications with HSD17B3 and Genital Diseases, Male
 Prostatic Diseases Antibodies  >10 publications with HSD17B3 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >9 publications with HSD17B3 and Prostatic Neoplasms
 Hyperplasia Antibodies  >6 publications with HSD17B3 and Hyperplasia
 Infertility, Male Antibodies  >3 publications with HSD17B3 and Infertility, Male
 Prenatal Exposure Delayed Effects Antibodies  >3 publications with HSD17B3 and Prenatal Exposure Delayed Effects
 17-Hydroxysteroid Dehydrogenase Deficiency Antibodies  >3 publications with HSD17B3 and 17-Hydroxysteroid Dehydrogenase Deficiency
 Ovarian Diseases Antibodies  >3 publications with HSD17B3 and Ovarian Diseases
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >35 publications with HSD17B3 and Testis
 Brain Antibodies  >8 publications with HSD17B3 and Brain
 Placenta Antibodies  >2 publications with HSD17B3 and Placenta
 Bone Antibodies  >1 publications with HSD17B3 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with HSD17B3 and Uncharacterized Tissue
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