NP_446252.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
thioredoxin
NCBI Official Synonym Full Names
thioredoxin 1
NCBI Official Synonym Symbols
NCBI Protein Information
thioredoxin
UniProt Protein Name
Thioredoxin
UniProt Synonym Gene Names
UniProt Entry Name
THIO_RAT
NCBI Summary for Txn1
protein-disulfide reductase enzyme that is important for redox signalling during apoptosis and cell growth [RGD, Feb 2006]
UniProt Comments for Txn1
TXN: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA- binding activity in a redox-dependent manner. Up-regulated by ionizing radiation. Belongs to the thioredoxin family.
Protein type: Nuclear receptor co-regulator
Cellular Component: cell soma; mitochondrion; axon; cytoplasm; dendrite; extracellular region; nucleus; cytosol
Molecular Function: thioredoxin-disulfide reductase activity; enzyme binding; protein disulfide oxidoreductase activity; peptide disulfide oxidoreductase activity
Biological Process: response to drug; negative regulation of protein export from nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation; glycerol ether metabolic process; response to radiation; response to selenium ion; regulation of transcription, DNA-dependent; cell redox homeostasis; regulation of protein import into nucleus, translocation; response to axon injury; response to activity; positive regulation of DNA binding
Research Articles on Txn1
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Products associated with anti-Txn1 antibody
Pathways associated with anti-Txn1 antibody
Diseases associated with anti-Txn1 antibody
Organs/Tissues associated with anti-Txn1 antibody
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