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anti-TG antibody :: Mouse anti-Human Thyroglobulin, T3-specific Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604760 anti-TG antibody
Unit / Price
1 mg  /  $765 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroglobulin, T3-specific (TG), Monoclonal Antibody

 Also Known As   

Thyroglobulin, T3-specific

 Product Synonym Names    Anti -Thyroglobulin, T3-specific
 Product Gene Name   

anti-TG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000008.10 (133879205..134147143). Location: 8q24
 OMIM    188450
 3D Structure    ModBase 3D Structure for P01266
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9F72
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human Thyroglobulin, T3-specific.
 Purity/Purification    Affinity Purified
Purified by Protein G chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
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 Immunogen    Human Thyroglobulin.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-TG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TG antibody

   Human Thyroglobulin (Tg) is a 660kD, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobulin Tg was referred to as 'colloid.' Human Thyroglobulin (Tg) is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine. Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against human Thyroglobulin (Tg). Human Thyroglobulin Tg-specific antibodies help in the diagnosis of these diseases, but they also may be present in apparently healthy euthyroid individuals. Human Thyroglobulin (Tg) levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin (Tg) levels in the blood can also be elevated in cases of Graves disease.
 Product Categories/Family for anti-TG antibody    Antibodies; Abs to Hormones, Steroids
 Applications Tested/Suitable for anti-TG antibody   

ELISA (EL/EIA)

 Application Notes for anti-TG antibody    Suitable for use in ELISA.
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NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
 NCBI GI #    37174
 NCBI GeneID    7038
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 UniProt Primary Accession #    P01266 [Other Products]
 UniProt Secondary Accession #    O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3 [Other Products]
 UniProt Related Accession #    P01266; Q59GF0; Q9NYD9; Q9NYM1 [Other Products]
 Molecular Weight    304,790 Da [Similar Products]
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 NCBI Official Full Name    thyroglobulin
 NCBI Official Synonym Full Names    thyroglobulin
 NCBI Official Symbol    TG [Similar Products]
 NCBI Official Synonym Symbols   
TGN; AITD3
[Similar Products]
 NCBI Protein Information    thyroglobulin; OTTHUMP00000227159
 UniProt Protein Name    Thyroglobulin
 Protein Family    Thyroglobulin
 UniProt Gene Name    TG [Similar Products]
 UniProt Entry Name    THYG_HUMAN
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 NCBI Summary for TG    Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]
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 UniProt Comments for TG    TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
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 Research Articles on TG    1. Patients with detectable Tg during the last (1)(3)(1)I treatment and a negative post-therapeutic WBS have significant earlier and more recurrences than patients without detectable Tg.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TG antibodyPathways associated with anti-TG antibody
 Reference Product  PubMed Publications
 APCS antibody  >25 publications with TG and APCS
 HSPA5 antibody  >3 publications with TG and HSPA5
 CTSL1 antibody  >3 publications with TG and CTSL1
 LRP2 antibody  >2 publications with TG and LRP2
 Products by Pathway  Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
Diseases associated with anti-TG antibodyOrgans/Tissues associated with anti-TG antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2583 publications with TG and Neoplasms
 Thyroid Diseases Antibodies  >1974 publications with TG and Thyroid Diseases
 Diabetes Mellitus Antibodies  >1632 publications with TG and Diabetes Mellitus
 Insulin Resistance Antibodies  >1404 publications with TG and Insulin Resistance
 Fatty Liver Antibodies  >1067 publications with TG and Fatty Liver
 Endocrine Gland Neoplasms Antibodies  >1017 publications with TG and Endocrine Gland Neoplasms
 Head and Neck Neoplasms Antibodies  >990 publications with TG and Head and Neck Neoplasms
 Thyroid Neoplasms Antibodies  >958 publications with TG and Thyroid Neoplasms
 Hypercholesterolemia Antibodies  >664 publications with TG and Hypercholesterolemia
 Kidney Diseases Antibodies  >612 publications with TG and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12223 publications with TG and Blood
 Liver Antibodies  >2636 publications with TG and Liver
 Thyroid Antibodies  >2470 publications with TG and Thyroid
 Muscle Antibodies  >1704 publications with TG and Muscle
 Brain Antibodies  >1489 publications with TG and Brain
 Kidney Antibodies  >917 publications with TG and Kidney
 Connective Tissue Antibodies  >792 publications with TG and Connective Tissue
 Lymph Node Antibodies  >510 publications with TG and Lymph Node
 Intestine Antibodies  >440 publications with TG and Intestine
 Pancreas Antibodies  >303 publications with TG and Pancreas
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