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anti-Tshr antibody :: Mouse anti-Human Thyrotrophin Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603375 anti-Tshr antibody
Unit / Price
0.2 mg  /  $890 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyrotrophin Receptor (Tshr), Monoclonal Antibody

★Popular Item★
 Also Known As   

Thyrotrophin Receptor

 Product Synonym Names    Anti -Thyrotrophin Receptor
 Product Gene Name   

anti-Tshr antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_005105.2 (115024999..115162531). Location: 6q31
 3D Structure    ModBase 3D Structure for P21463
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    3H3042
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes the human thyrotrophin receptor, binding to an extracellular domain.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
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 Immunogen    External domain of human thyrotrophin receptor linked to GST.
 Recommended Negative Controls    Mouse IgG2a Negative Control
 Fusion Partners    Spleen cells from immunized BALB/c mice were fused with cells of the NS1/Ag4.1 myeloma cell line.
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-Tshr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for Tshr purchase    GPCRs,- a multitude of extracellular signaling transducers. Teamed with their intracellular partners - G-proteins- they are integral in homeostasis and imbalances can create conditions resulting in clinical human autoimmune pathologies such as Graves disease and Hashimoto thyroiditis. These autoimmune thyroid disease (s) results from generation of antibodies anti thyroid stimulating hormone (thyrotropin TSH) which can also bind and stimulate the thyrotropin receptor (TSHR) and TSH receptor. Translational and therapeutic research, targeted to thyrotropin receptor and not related family gene members with conserved domain structures, requires highly selective custom antibody production to generate our receptor antibody. MyBiosource has a mouse mAb ideal for research applications of cell lysates with broad AMP secondary antibodies detection. This product recognizes an extracellular domain distinct from other protein family antibodies based on Pubmed alignment tool BLAST database bioinformatics. Compare our value to other TSH receptor or thyroid antibodies and order today at 866 697 8378.
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 Product Categories/Family for anti-Tshr antibody    Antibodies; Abs to Hormones, Steroids
 Applications Tested/Suitable for anti-Tshr antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-Tshr antibody    Flow Cytometry: 1:100-1:1000, Western Blotting: 1:1000, Immunohistochemistry: Frozen, Paraffin, Immunoprecipitation, Optimal working dilutions to be determined by researcher.
Flow Cytometry: Use 10ul of the suggested working dilution to label 10e6 cells in 100ul.
Immunohistochemistry: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
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NCBI/Uniprot data below describe general gene information for Tshr. It may not necessarily be applicable to this product.
 NCBI GI #    6981680
 NCBI GeneID    25360
 NCBI Accession #    NP_037020.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012888.1 [Other Products]
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 UniProt Primary Accession #    P21463 [Other Products]
 UniProt Related Accession #    P21463; Q9ESJ8 [Other Products]
 Molecular Weight    86,475 Da [Similar Products]
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 NCBI Official Full Name    thyrotropin receptor
 NCBI Official Synonym Full Names    thyroid stimulating hormone receptor
 NCBI Official Symbol    Tshr [Similar Products]
 NCBI Official Synonym Symbols   
TSHRA
[Similar Products]
 NCBI Protein Information    thyrotropin receptor; TSH-R; thyroid-stimulating hormone receptor
 UniProt Protein Name    Thyrotropin receptor
 UniProt Synonym Protein Names   
Thyroid-stimulating hormone receptor
 Protein Family    Thyrotropin receptor
 UniProt Gene Name    Tshr [Similar Products]
 UniProt Entry Name    TSHR_RAT
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 NCBI Summary for Tshr    acts as a G-protein coupled receptor for thyroid-stimulating hormone; induces increased cAMP levels [RGD]
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 UniProt Comments for Tshr    TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Cellular Component: integral to membrane; plasma membrane; receptor complex; lipid raft

Molecular Function: thyroid-stimulating hormone receptor activity

Biological Process: regulation of locomotion; inner ear receptor stereocilium organization and biogenesis; adult locomotory behavior; inner ear receptor cell development; B cell differentiation; positive regulation of cell proliferation; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway
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 Research Articles on Tshr    1. TSHR is present and functional in hepatocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Tshr antibodyDiseases associated with anti-Tshr antibody
 Products by Pathway  Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >614 publications with Tshr and Thyroid Diseases
 Hyperthyroidism Antibodies  >401 publications with Tshr and Hyperthyroidism
 Graves Disease Antibodies  >367 publications with Tshr and Graves Disease
 Neoplasms Antibodies  >140 publications with Tshr and Neoplasms
 Thyroid Neoplasms Antibodies  >133 publications with Tshr and Thyroid Neoplasms
 Head and Neck Neoplasms Antibodies  >128 publications with Tshr and Head and Neck Neoplasms
 Endocrine Gland Neoplasms Antibodies  >128 publications with Tshr and Endocrine Gland Neoplasms
 Thyroiditis, Autoimmune Antibodies  >82 publications with Tshr and Thyroiditis, Autoimmune
 Carcinoma Antibodies  >71 publications with Tshr and Carcinoma
 Congenital Hypothyroidism Antibodies  >55 publications with Tshr and Congenital Hypothyroidism
Organs/Tissues associated with anti-Tshr antibody
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >36 publications with Tshr and Adipose Tissue
 Brain Antibodies  >24 publications with Tshr and Brain
 Pancreas Antibodies  >1 publications with Tshr and Pancreas
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