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anti-SERPINA7 antibody :: Thyroxine Binding Globulin (TBG) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS311702 anti-SERPINA7 antibody
Unit / Price
1 mg  /  $360 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Thyroxine Binding Globulin (TBG) (SERPINA7), Monoclonal Antibody

 Also Known As   

MAb to TBG

 Product Synonym Names    Monoclonal Antibody to Thyroxine Binding Globulin (TBG)
 Product Gene Name   

anti-SERPINA7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (105277190..105282718, complement). Location: Xq22.2
 OMIM    314200
 3D Structure    ModBase 3D Structure for P05543
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 Clonality    Monoclonal
 Isotype    IgG2a, kappa
 Clone Number    027-10439
 Host    Host: Mouse
Source: Ascites
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 Specificity    Thyroxine Binding Globulin (TBG)
Thyroxine Binding Globulin (TBG)
 Purity/Purification    >90% pure (SDS-PAGE). Protein A chromatography.
Product is sterile filtered.
 Form/Format    Purified, Liquid
 Concentration    5.1mg/ml (OD280nm, E^0.1% = 1.4) (lot specific)
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 Affinity Constant    1 x 10^9
 Buffer    10mM Phosphate, pH 7.4 containing 150mM Sodium chloride
 Preservative    None. OPEN ASEPTICALLY!
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 Preparation and Storage    Short term (up to 7 days) store at 2 to 8 degree C. Long term, aliquot and store at <-40 degree C. If aliquoted for long term storage, fill volume should be equal to or greater than 50% of the nominal fill volume of the vial used. Avoid repeated freeze/th
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SERPINA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SERPINA7 antibody    Monoclonal Antibodies to Hormones and Steroids
NCBI/Uniprot data below describe general gene information for SERPINA7. It may not necessarily be applicable to this product.
 NCBI GI #    205277441
 NCBI GeneID    6906
 NCBI Accession #    NP_000345.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000354.5 [Other Products]
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 UniProt Primary Accession #    P05543 [Other Products]
 UniProt Secondary Accession #    D3DUX1 [Other Products]
 UniProt Related Accession #    P05543 [Other Products]
 Molecular Weight    46,325 Da [Similar Products]
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 NCBI Official Full Name    thyroxine-binding globulin
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
 NCBI Official Symbol    SERPINA7 [Similar Products]
 NCBI Official Synonym Symbols   
TBG; FLJ17820
[Similar Products]
 NCBI Protein Information    thyroxine-binding globulin; serpin A7; OTTHUMP00000023778; OTTHUMP00000023779; T4-binding globulin; thyroxin-binding globulin; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
 UniProt Protein Name    Thyroxine-binding globulin
 UniProt Synonym Protein Names   
Serpin A7; T4-binding globulin
 Protein Family    Thyroxine-binding globulin
 UniProt Gene Name    SERPINA7 [Similar Products]
 UniProt Synonym Gene Names    TBG [Similar Products]
 UniProt Entry Name    THBG_HUMAN
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 NCBI Summary for SERPINA7    There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3 -triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.
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 UniProt Comments for SERPINA7    Function: Major thyroid hormone transport protein in serum.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Polymorphism: Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid. TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile.

Involvement in disease: Defects in SERPINA7 are a cause of thyroxine-binding globulin deficiency (TBG deficiency) [

MIM:314200]. Mutations in the SERPINA7 gene can result as a whole spectrum of deficiencies, characterized by either reduced or increased TBG levels in the serum. Patients show, respectively, reduced or elevated protein-bound iodine but are euthyroid.

Sequence similarities: Belongs to the serpin family.
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 Research Articles on SERPINA7    1. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-SERPINA7 antibodyOrgans/Tissues associated with anti-SERPINA7 antibody
 Disease Name  Pubmed Publications
 Head and Neck Neoplasms Antibodies  >1 publications with SERPINA7 and Head and Neck Neoplasms
 Esophageal Neoplasms Antibodies  >1 publications with SERPINA7 and Esophageal Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with SERPINA7 and Carcinoma, Squamous Cell
 Inflammation Antibodies  >1 publications with SERPINA7 and Inflammation
 Neoplasms Antibodies  >1 publications with SERPINA7 and Neoplasms
 Precancerous Conditions Antibodies  >1 publications with SERPINA7 and Precancerous Conditions
 Fatty Liver Antibodies  >1 publications with SERPINA7 and Fatty Liver
 Carcinoma Antibodies  >1 publications with SERPINA7 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with SERPINA7 and Liver
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