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anti-TFPI antibody :: anti-Human Tissue Factor Pathway Inhibitor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135043 anti-TFPI antibody
Unit / Price
0.1 mg  /  $320 +1 FREE 8GB USB
0.5 mg  /  $605 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Factor Pathway Inhibitor (TFPI), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti-Human Tissue Factor Pathway Inhibitor

 Product Gene Name   

anti-TFPI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (188328957..188419219, complement). Location: 2q32
 OMIM    152310
 3D Structure    ModBase 3D Structure for P10646
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    5138
 Host    Host: Mouse
Source: Mouse ascites
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Liquid
 Concentration    8.6 mg/ml (lot specific)
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 Aliquot    1 x 0.1mg
 Volume    0.011ml
 Immunogen    Synthetic 16 amino acid peptide from the amino terminus of TFPI (Human).
 Target Information    Recognises Tissue Factor Pathway Inhibitor
 Target Molecular Weight    35000
 Buffer    50% Glycerol
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -20 degree C. Shelf Life: 12 months from delivery
Shipping: COld packs
 Other Notes    Small volumes of anti-TFPI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TFPI antibody

   Clone number AHTFPI-5138. Reactive to: Human Tissue Factor Pathway Inhibitor. Mouse monoclonal of isotype IgG.
 Product Categories/Family for anti-TFPI antibody    Tissue Factor; Monoclonal Antibodies to Human Tissue Factor Pathway Inhibitor
 Applications Tested/Suitable for anti-TFPI antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TFPI. It may not necessarily be applicable to this product.
 NCBI GI #    73760409
 NCBI GeneID    7035
 NCBI Accession #    NP_001027452.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001032281.2 [Other Products]
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 UniProt Primary Accession #    P10646 [Other Products]
 UniProt Secondary Accession #    O95103; Q53TS4 [Other Products]
 UniProt Related Accession #    P10646 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    tissue factor pathway inhibitor isoform b
 NCBI Official Synonym Full Names    tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
 NCBI Official Symbol    TFPI [Similar Products]
 NCBI Official Synonym Symbols   
EPI; TFI; LACI; TFPI1
[Similar Products]
 NCBI Protein Information    tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor
 UniProt Protein Name    Tissue factor pathway inhibitor
 UniProt Synonym Protein Names   
Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor
 Protein Family    Tissue factor pathway inhibitor
 UniProt Gene Name    TFPI [Similar Products]
 UniProt Synonym Gene Names    LACI; TFPI1; TFPI; EPI; LACI [Similar Products]
 UniProt Entry Name    TFPI1_HUMAN
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 NCBI Summary for TFPI    This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TFPI    TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Membrane protein, GPI anchor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: extracellular space; cell surface; endoplasmic reticulum; extracellular region; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: blood coagulation, extrinsic pathway; blood coagulation
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 Research Articles on TFPI    1. Overexpression of human TFPI affected the apoptotic activity through a process independent of caspase-3, and was also able to increase the activation of the NF- kappaB pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFPI antibodyPathways associated with anti-TFPI antibody
 Reference Product  PubMed Publications
 THBS1 antibody  >2 publications with TFPI and THBS1
 F10 antibody  >2 publications with TFPI and F10
 MMP9 antibody  >1 publications with TFPI and MMP9
 MMP7 antibody  >1 publications with TFPI and MMP7
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram
Diseases associated with anti-TFPI antibodyOrgans/Tissues associated with anti-TFPI antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >514 publications with TFPI and Cardiovascular Diseases
 Inflammation Antibodies  >186 publications with TFPI and Inflammation
 Neoplasms Antibodies  >181 publications with TFPI and Neoplasms
 Venous Thrombosis Antibodies  >122 publications with TFPI and Venous Thrombosis
 Necrosis Antibodies  >76 publications with TFPI and Necrosis
 Carcinoma Antibodies  >72 publications with TFPI and Carcinoma
 Myocardial Infarction Antibodies  >64 publications with TFPI and Myocardial Infarction
 Kidney Diseases Antibodies  >57 publications with TFPI and Kidney Diseases
 Pain Antibodies  >37 publications with TFPI and Pain
 Neoplasm Metastasis Antibodies  >34 publications with TFPI and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1167 publications with TFPI and Blood
 Vascular Antibodies  >515 publications with TFPI and Vascular
 Embryonic Tissue Antibodies  >99 publications with TFPI and Embryonic Tissue
 Muscle Antibodies  >95 publications with TFPI and Muscle
 Lung Antibodies  >82 publications with TFPI and Lung
 Kidney Antibodies  >78 publications with TFPI and Kidney
 Heart Antibodies  >74 publications with TFPI and Heart
 Liver Antibodies  >73 publications with TFPI and Liver
 Umbilical Cord Antibodies  >46 publications with TFPI and Umbilical Cord
 Placenta Antibodies  >45 publications with TFPI and Placenta
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