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anti-TIMP1 antibody :: Mouse anti-Rat Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090897 anti-TIMP1 antibody
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $115 +1 FREE 8GB USB
0.05 mg  /  $155 +1 FREE 8GB USB
0.1 mg  /  $195 +1 FREE 8GB USB
0.2 mg  /  $250 +1 FREE 8GB USB
1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tissue Inhibitors Of Metalloproteinase 1 (TIMP1), Monoclonal Antibody

 Also Known As   

Biotin-Linked Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

 Product Gene Name   

anti-TIMP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X03124 mRNA
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Rat
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 Concentration    500ug/ml (lot specific)
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 Conjugation    Biotin
 Immunogen    Cys24~Ala217
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 Other Notes    Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TIMP1 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.
 NCBI GI #    994731
 NCBI GeneID    7076
 NCBI Accession #    AAA75558.1 [Other Products]
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 UniProt Secondary Accession #    Q14252; Q9UCU1 [Other Products]
 UniProt Related Accession #    P01033 [Other Products]
 Molecular Weight    23,171 Da
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 NCBI Official Full Name    tissue inhibitor of metalloproteinase 1, partial
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 1
 NCBI Official Symbol    TIMP1 [Similar Products]
 NCBI Official Synonym Symbols   
EPA; EPO; HCI; CLGI; TIMP; TIMP-1
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 1
 UniProt Protein Name    Metalloproteinase inhibitor 1
 UniProt Synonym Protein Names   
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP1 [Similar Products]
 UniProt Synonym Gene Names    CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1 [Similar Products]
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 NCBI Summary for TIMP1    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP1    TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp11.3

Cellular Component: basement membrane; endoplasmic reticulum lumen; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: cytokine activity; growth factor activity; metalloendopeptidase inhibitor activity; protease binding; protein binding; zinc ion binding

Biological Process: aging; cartilage development; cell activation; cellular protein metabolic process; extracellular matrix disassembly; negative regulation of apoptosis; negative regulation of catalytic activity; negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; positive regulation of cell proliferation; post-translational protein modification; response to cytokine; response to hormone; response to peptide hormone; wound healing
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 Research Articles on TIMP1    1. The plasma levels of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, tissue inhibitor of metalloproteinases (TIMP)-1 are increased in myelofibrosis (MF) patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TIMP1 antibodyPathways associated with anti-TIMP1 antibody
 Reference Product  PubMed Publications
 MMP9 antibody  >289 publications with TIMP1 and MMP9
 MMP2 antibody  >258 publications with TIMP1 and MMP2
 MMP1 antibody  >141 publications with TIMP1 and MMP1
 TGFB1 antibody  >74 publications with TIMP1 and TGFB1
 MMP14 antibody  >26 publications with TIMP1 and MMP14
 FN1 antibody  >10 publications with TIMP1 and FN1
 EGF antibody  >8 publications with TIMP1 and EGF
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
Diseases associated with anti-TIMP1 antibodyOrgans/Tissues associated with anti-TIMP1 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >160 publications with TIMP1 and Fibrosis
 Inflammation Antibodies  >143 publications with TIMP1 and Inflammation
 Cardiovascular Diseases Antibodies  >138 publications with TIMP1 and Cardiovascular Diseases
 Vascular Diseases Antibodies  >101 publications with TIMP1 and Vascular Diseases
 Liver Diseases Antibodies  >82 publications with TIMP1 and Liver Diseases
 Necrosis Antibodies  >79 publications with TIMP1 and Necrosis
 Heart Diseases Antibodies  >73 publications with TIMP1 and Heart Diseases
 Female Urogenital Diseases Antibodies  >58 publications with TIMP1 and Female Urogenital Diseases
 Liver Cirrhosis Antibodies  >52 publications with TIMP1 and Liver Cirrhosis
 Breast Neoplasms Antibodies  >38 publications with TIMP1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >265 publications with TIMP1 and Blood
 Liver Antibodies  >112 publications with TIMP1 and Liver
 Muscle Antibodies  >104 publications with TIMP1 and Muscle
 Lung Antibodies  >94 publications with TIMP1 and Lung
 Bone Antibodies  >79 publications with TIMP1 and Bone
 Heart Antibodies  >78 publications with TIMP1 and Heart
 Connective Tissue Antibodies  >63 publications with TIMP1 and Connective Tissue
 Kidney Antibodies  >57 publications with TIMP1 and Kidney
 Skin Antibodies  >54 publications with TIMP1 and Skin
 Brain Antibodies  >48 publications with TIMP1 and Brain
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